Psychoactive substance index
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Psychedelics
Entheogens
Dissociatives
Deliriants
Cannabinoids
Miscellaneous
Depressants
Stimulants
Nootropics
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A psychoactive substance is a chemical substance—other than a nutrient or essential dietary ingredient—that alters brain function to produce temporary changes in sensation, perception, mood, consciousness, cognition, and behavior.
Psychoactive substances have been used by humans for a variety of purposes since recorded history. For example, they may be used as medicine, as recreational substances for their euphoric effects and novelty value, as entheogens for ritual or spiritual purposes, or as scientific research probes for studying the brain and mind. The latter two have particular relevance for practitioners of psychonautics.
The Psychoactive Substance Index (PSI) is designed to catalog and provide relevant, accurate, and unbiased information for any and all mind-altering substances known to humankind, with a special focus on those with potential applications as mind-expanding tools.
The individual articles detail not just the history, chemistry, pharmacology, toxicity, and legality of each substance, but also its user-reported subjective effects (i.e. phenomenology). This is achieved in accordance with a standardized system of definitions and terminologies proposed in the Subjective Effect Index (SEI).
Please see our summary index to view conveniently condensed versions of each article.
Note: This list should only include substances that have a documented history of human use. Do not include substances that are merely theoretical or lack reliable user experience reports and data!
Psychedelics 
-
Classical psychedelics
-
Lysergamides
-
Base tryptamines
-
Substituted tryptamines
- 4-AcO-DALT
- 4-AcO-DET
- 4-AcO-DiPT
- 4-AcO-DMT (Psilacetin)
- 4-AcO-DPT
- 4-AcO-EiPT
- 4-AcO-EPT
- 4-AcO-MALT
- 4-AcO-McPT
- 4-AcO-MET
- 4-AcO-MiPT
- 4-AcO-MPT
- 4-AcO-PiPT
- 4-HO-DALT
- 4-HO-DET
- 4-HO-DiPT
- 4-HO-DPT
- 4-HO-EiPT
- 4-HO-EPT
- 4-HO-MALT
- 4-HO-McPT
- 4-HO-MET (Metocin)
- 4-HO-MiPT
- 4-HO-MPT
- 4-HO-PiPT
- 4-HO-5-Meo-DMT
- 4-MeO-MiPT
- 4-PO-DET (Ethocybin)
- 5,6-MDO-DMT
- 5-Br-DMT
- 5-Cl-aMT
- 5-Cl-DMT
- 5-Ethyl-DMT
- 5-Ethoxy-DMT
- 5-MeO-2-TMT
- 5-MeO-aET
- 5-MeO-aMT
- 5-MeO-DALT
- 5-MeO-DET
- 5-MeO-DiPT (Foxy)
- 5-MeO-DMT
- 5-MeO-DPT
- 5-MeO-EiPT
- 5-MeO-MALT
- 5-MeO-MET
- 5-MeO-MiPT (Moxy)
- 5-MeO-PiPT
- 5-MeS-DMT
- Baeocystin (4-PO-NMT)
- Bufotenin (5-HO-DMT)
- Ibogaine
- Psilocin (4-HO-DMT)
- Psilocybin (4-PO-DMT)
- RU-28306
-
Mescaline homologues
- 3C-E
- 3C-P
- Allylescaline
- Escaline
- Isoproscaline
- Mescaline
- Methallylescaline (MAL)
- Proscaline
- TMA (TMA-1)
-
2C-x
-
2C-T-x
-
2C-x derivatives
-
DOx
-
DOx derivatives
-
N-Benzyl phenethylamines
-
Miscellaneous phenethylamines
-
Others
- 5-MeO-DiBF
- Efavirenz
- Glaucine
- Lorcaserin
- Mirtazapine (Remeron)
Entheogens 
-
- Argyreia nervosa (Hawaiian Baby Woodrose)
- Acacia confusa
- Amanita muscaria
- Ayahuasca
- Banisteriopsis caapi
- Cannabis
- Changa
- Datura
- Iboga
- Ipomoea tricolor (Morning Glory)
- Mimosa hostilis
- Peyote
- Psilocybin mushrooms
- Salvia divinorum
- San Pedro
- Syrian rue
- Yopo
-
β-Carbolines
Dissociatives 
-
Arylcyclohexylamines
- 2-Bromodeschloroketamine (2-BDCK)
- 2-Fluorodeschloroketamine (2-FDCK)
- 3,4-MD-PCP
- 2'-Oxo-PCE (O-PCE)
- 2'-Oxo-PCM (Deschloroketamine, DCK)
- 3-Cl-PCP
- 3-F-PCP (3-Fluoro-PCP)
- 3-HO-PCE
- 3-HO-PCP
- 3-Me-PCP
- 3-Me-PCPy
- 3-MeO-PCE
- 3-MeO-PCMo
- 3-MeO-PCP
- 4-MeO-PCP
- Deoxymethoxetamine (DMXE, 3D-MXE)
- Eticyclidine (PCE)
- Fluorexetamine (FXE)
- Hydroxetamine (HXE)
- Ketamine
- R-Ketamine (Arketamine)
- S-Ketamine (Esketamine)
- Methoxetamine (MXE)
- Methoxisopropamine (MXiPr)
- Methoxpropamine (MXPr)
- Phencyclidine (PCP)
- Tenocyclidine
- Tiletamine
-
Morphinans
- Dextromethorphan (DXM)
- Dextrorphan (DXO)
- Dextromethorphan (DXM)
-
Diarylethylamines
-
Adamantanes
- Amantadine
- Memantine
- Rimantadine ("Flumadine")
-
Others
- Dexoxadrol
- Dizoclipine (MK-801)
- Etoxadrol
- HA-966
- Ibogaine
- Nitrous oxide (N2O)
- Xenon
Deliriants 
-
Tropane alkaloids
- Atropine
- Hyoscyamine
- Scopolamine (Hyoscine)
-
Antihistamines
- Diphenhydramine (Benadryl, DPH)
- Doxylamine
- Orphenadrine
- Promethazine
-
Others
- Amantadine
- Benzydamine
- Biperiden (Akineton)
- Cyproheptadine
- Mirtazapine (Remeron)
- Myristicin (Nutmeg)
Cannabinoids 
-
Phytocannabinoids
Quasi-psychedelic THC* cannabinoids, and cannabi* (CB*) substances that can be converted to quasi-psychedelic THC* cannabinoids (for example CBD, and CBDP can be converted with citric acid to THC, and THCP, respectively):
- Cannabidiol (CBD)
- Cannabidiolic acid (CBDA)
- CBDjd
- Cannabidihexol (CBDH)
- Cannabidiphorol (CBDP)
- Tetrahydrocannabinol (THC, Delta-9-THC)
- Tetrahydrocannabinolic acid (THCA)
- Tetrahydrocannabioctyl (THCjd)
- Tetrahydrocannabihexol (THCH)
- Tetrahydrocannabiphorol (THCP)
-
Synthetic cannabinoids
Miscellaneous 
-
κ-opioid receptor agonists
-
Oneirogens
- 5-Hydroxytryptophan (5-HTP)
- Acetylcholine boosters
- Acetylcholinesterase inhibitors
- Calea ternifolia (Calea zacatechichi)
- Entada rheedii (African dream herb)
- Galantamine
- Huperzine A
- Melatonin
- Silene undulata'' (African dream root)
- Vitamin B12
-
Antidotes/Antagonists
- Activated Charcoal (for orally ingested substances)
- Atropine (for nerve agent poisoning)
- Cyproheptadine (for serotonin syndrome)
- Dantrolene (for serotonin syndrome or associated effects)
- Flumazenil (for benzodiazepine overdose)
- Ketanserin (for hypertension caused by serotonergic agents)
- N-acetylcysteine (for acetaminophen overdose)
- Nalmefene (for opioid overdose)
- Naloxone (for opioid overdose)
- Tolazoline (for hypertension caused by adrenergic agents. Can reverse serotonergic vasoconstriction from agents like 25i-NBOMe or DOB)
-
Combinations
-
Inhalants
- Acetone
- Butane
- Chloroform
- Diethyl ether (Ether)
- Gasoline
- Haloalkanes
- Nitrous oxide (N2O)
- Alkyl nitrites (Poppers)
- Propane
- Toluene
- Xenon
-
Sigmaergics
- DHEA
- DXM
- Memantine
- PRE-084
- Progesterone
- Various
Miscellaneous
-
Various
- Cabergoline
- Ergotamine
- HCl (Hydrochloric acid)
- iso-LSD
- nor-LSD
- PRE-084
- Sildenafil (Viagra)
- Tadalafil (Cialis)
- Testosterone
Depressants 
-
Benzodiazepines
- 3-Hydroxyphenazepam
- Alprazolam (Xanax)
- Bromazepam
- Bromazolam
- Chlordiazepoxide (Librium)
- Cinazepam
- Cinolazepam
- Clobazam
- Clonazepam (Klonopin)
- Clonazolam
- Clorazepate
- Diazepam (Valium)
- Diclazepam
- Estazolam
- Flualprazolam
- Flubromazepam
- Flubromazolam
- Flunitrazepam (Rohypnol)
- Flunitrazolam
- Flurazepam
- Gidazepam
- Loprazolam
- Lorazepam (Ativan)
- Lormetazepam
- Midazolam (Dormicum)
- Nifoxipam
- Nitrazolam
- Nordazepam
- Norflurazepam
- Oxazepam
- Phenazepam
- Pyrazolam
- Quazepam
- Ro5-4864
- Temazepam
- Tetrazepam
- Triazolam (Halcion)
-
Thienodiazepines
-
Barbiturates
-
GABAA-α1 agonists
- Gaboxadol
- Ibotenic acid
- Muscimol
- Pagoclone
- Quazepam
- Zaleplon
- Zolpidem (Ambien)
- Zopiclone
- Eszopiclone (Lunesta)
-
Gabapentinoids
- F-Phenibut
- Gabapentin
- Mirogabalin
- Phenibut
- Pregabalin (Lyrica)
-
Other GABAergics
- 1,4-Butanediol (1,4-B)
- 2-Methyl-2-butanol (2M2B)
- Alcohol
- Baclofen
- Bretazenil
- Carisoprodol (Soma)
- Chloral hydrate
- Emylcamate
- F-Phenibut
- Flumazenil
- GABA
- GBL
- GHB (Sodium oxybate)
- GHV
- Mebroqualone
- Meprobamate
- Methaqualone (Qualuude)
- Nitromethaqualone
- Phenibut
- Phenprobamate
- Potassium bromide
- Propofol
- SL-164
-
Opioids
- 2-Methyl-AP-237
- Acetylfentanyl
- AP-237
- AP-238
- Brorphine
- Buprenorphine
- Butyrfentabyl
- Carfentanyl
- Codeine
- Desomorphine (Krokodil)
- Dextromoramide
- Dextropropoxyphene
- Diacetylmorphine (Heroin)
- Dihydrocodeine
- Ethylmorphine
- Etodesnitazene (Etazene)
- Etonitazene
- Etonitazepipene
- Etorphine
- Fentanyl
- Fluonitazene
- Furanylfentanyl
- Hydrocodone (Vicodin)
- Hydromorphone (Dilaudid)
- Isotonitazene
- Kratom
- Lefetamine
- Levomethorphan
- Methadone
- Metodesnitazene
- Metonitazene
- Morphine
- O-Desmethyltramadol (O-DSMT)
- Oxycodone (OxyContin)
- Oxymorphone
- Pethidine
- Sufentanil
- Tapentadol
- Thebaine
- Tianeptine
- Tilidine
- Tramadol
- U-47700
- U-48800
- U-49900
-
Antipsychotics
- Amitriptiline
- Aripiprazole (Abilify)
- Chlorprothixene (Truxal)
- Clotiapine (Entumine)
- Clozapine
- Haloperidol (Haldol)
- Levomepromazine (Nozinan)
- Olanzapine (Zyprexa)
- Prochlorperazine
- Promazine
- Quetiapine (Seroquel)
- Risperidone (Risperdal)
-
Others
- Clonidine
- Dexmedetomidine
- Diphenhydramine (Benadryl, DPH)
- Guanfacine
- Mirtazapine (Remeron)
- Tizanidine
Stimulants 
-
Amphetamines
- 2-FA
- 2-FEA
- 2-FMA
- 3-FA
- 3-FEA
- 3-FMA
- 3-MMA (3-MeMA)
- 4-FA
- 4-FEA
- 4-FMA
- 4-MMA (4-MeMA)
- Amphetamine (Adderall)
- Dextroamphetamine (Dexedrine)
- Levoamphetamine
- Cathine
- Ephedrine
- Etilamfetamine (N-Ethylamphetamine)
- Fencamine
- Lefetamine
- Lisdexamfetamine (Vyvanse)
- Methamphetamine (Meth)
- Pseudoephedrine
-
Phenmetrazines
-
Phenidates
- 3,4-CTMP (3,4-DCMP)
- 4F-EPH
- 4F-MPH
- Ethylnapthidate (HDEP-28)
- Ethylphenidate (EPH)
- Isopropylphenidate (IPH / IPPH)
- Methylnaphthidate (HDMP-28)
- Methylphenidate (Ritalin)
- Dexmethylphenidate (Focalin)
-
Cathinones
- 2-MMC
- 3,4-DMMC
- 3-CEC
- 3-CMC
- 3-FMC
- 3-MEC
- 3-MMC
- 4-CEC
- 4-CMC
- 4-EMC
- 4-FMC
- 4-FPD
- 4-MC
- 4-MEC
- 4-MPD
- BMDP
- Buphedrone
- Butylone (βk-MBDB)
- Cathinone (Khat)
- Diethylpropion
- Ephylone (N-Ethylpentylone)
- Ethcathinone (ETH-CAT)
- Ethylone (βk-MDEA)
- Eutylone (N-Ethylbutylone)
- Hexedrone
- MDPT
- Mephedrone (4-MMC)
- Methcathinone
- Methylone (βk-MDMA)
- Mexedrone
- N-Ethylheptedrone (HEP)
- N-Ethylhexedrone (HEX-EN)
- N-Ethylpentedrone (NEP)
- N-Isopropylpentedrone (NiPP)
- Pentedrone
- Pentylone
-
Pyrrolidinophenones
-
Piperazines
-
Tropanes
-
Aminorexes
- 4,4'-DMAR (Serotoni)
- 4-Br-MAR
- 4-Cl-MAR
- 4-F-MAR
- 4-Methylaminorex (4-MAR)
- Aminorex
- Cyclazodone
- N-Methyl-Cyclazodone
- Pemoline
-
Xanthines
-
Others
- 1,3-DMAA
- 1,4-DMAA
- 2-AI
- β-OH-PHP
- Bromantane
- BTCP (Benocyclidine)
- Desoxypipradrol (2-DPMP)
- Dimethocaine
- DMHA
- Mephedrene (5-MMPA)
- Methiopropamine
- Nicotine
- NM-2-AI
- Phenethylamine
- Pipradol
- PPAP
- Prolintane
- Propylhexedrine (Benzedrex)
- Thiothinone
Nootropics 
-
Eugeroics
- Adrafinil
- Bisfluoromodafinil (Fl-Modafinil)
- Fladrafinil
- Fluorenol
- Modafinil
- N-Methylbisfluoromodafinil (Modafiendz)
-
Nutrients
-
Racetams
-
Others
Antidepressants
-
Atypical
- Agomelatine
- Bupropion (Wellbutrin)
- Lamotrigine
- Mirtazapine (Remeron)
- Tianeptine
- Trazodone
-
SSRI
- Citalopram
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Fluvoxamine
- Paroxetine (Paxil)
- Sertraline (Zoloft)
- Citalopram
-
SNRI
- Atomoxetine (Strattera)
- Desvenlafaxine
- Venlafaxine (Effexor)
-
MAOI/RIMA
Neurotransmitters
-
Amino acids
-
Monoamines
- Dopamine
- Epinephrine (Adrenaline)
- Histamine
- Melatonin
- Norepinephrine (Noradrenaline)
- Serotonin (5-HT)
-
Trace amines
- Catecholamines
- Phenethylamines
- Tryptamine
- Serotonin (5-HT)
-
Peptides
- BPC-157
- Cerebrolysin
- Dihexa
- DSIP (Delta-sleep-inducing peptide)
- Epitalon
- N-Acetyl Selank Amidate
- N-Acetyl Selank
- N-Acetyl Semax Amidate
- N-Acetyl Semax
- Neuropeptide S
- Oxytocin
- P21
- Selank
- Semax
-
Other