|Summary sheet: N-Ethylhexedrone|
|Common names||Hexen, Hex-en, NEH, Ethyl-Hexedrone|
|Substitutive name||N-Ethylhexedrone, N-Ethyl-nor-hexedrone|
|Routes of Administration|
N-Ethylhexedrone (also known as hexen or NEH) is a novel stimulant of the cathinone class that produces classical stimulant effects such as stimulation, disinhibition, thought acceleration, and euphoria when administered. Its effects are believed to be caused by its activity as an NDRI (norepinephrine-dopamine reuptake inhibitor), although this has yet to be scientifically validated.
As with many of its research chemical cathinone predecessors, N-ethylhexedrone is known to come in the form of either a white powder or crystallized shards which users can ingest to produce a powerful, fast-acting but short-lived euphoric stimulant effects which are comparable to those produced by crack-cocaine, NEP and α-PVP-related compounds, particularly when they are insufflated or vaporized.
Like other substituted cathinones, N-ethylhexedrone has gained notoriety for its associated tendency to induce compulsive redosing and addictive behaviors in a seemingly significant percentage of its users as well the ability to readily induce paranoia, anxiety, various delusional states and stimulant psychosis when abused, taken too frequently or in excess.
N-Ethylhexedrone was first synthesized in 2011 but became widely available in the research chemical market during late 2015, upon which it rapidly gained popularity. It is a prominent example of a contemporary designer drug specifically chosen to mimic and/or replace the functional and structural features of its recently-controlled predecessors, which are sometimes imprecisely grouped together by the media as "bath salts".
Little research exists about both N-ethylhexedrone as well as its parent compound, hexedrone, particularly with regards to its toxicity, addiction, and abuse potential, although many anecdotal information and reports do exist can make more information to this compound than various others like hexedrone or a-PVP Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with caution.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Toxicity and harm potential
- 5 Legal status
- 6 See also
- 7 External links
- 8 References
N-Ethylhexedrone is a molecule of the cathinone chemical class. The term "substituted cathinone" refers to a broad array of substances based on cathinone, the principally active constituent of the khat plant. Cathinone is principally constituted of a amphetamine core (a phenethylamine core with an alkyl group attached to the alpha carbon) and an oxygen group attached to the beta carbon. Cathinones are also known as the beta-ketone (βk) (double-bonded oxygen to the β-carbon) analogs of amphetamines.
Notably, the cathinone backbone can be modified in three different places to create hundreds of possible compounds, which include substituents such as on the aromatic ring, the alpha carbon, or the amine group.
Due to the lack of research regarding the substance, all proceeding discussion regarding the pharmacology of this compound derives from speculation based upon its structure and subjective effect similarities to other substituted cathinones especially NEP (N-ethyl-(nor)-pentedrone), pentedrone, a-PVP, and a-PHP and others.
N-ethylhexedrone most likely acts as both a powerful dopamine and norepinephrine reuptake inhibitor due to its substituted cathinone structure. This allows the endogenous neurotransmitters dopamine and norepinephrine to accumulate within the brain, resulting in extremely stimulating and euphoric effects.
The pharmacology of N-ethylhexedrone can perhaps be compared to the better known hexedrone. N-ethylhexedrone is an extended chain version of hexedrone, differing by a single carbon on the alpha-alkyl chain. It should be noted that extension of the carbon chain in this manner generally results in less potency than the parent compound. However, the addition of the ethyl group to the terminal amine (-NH2) group seems to counteract this and increase its potency significantly, much like is observed with NEP (N-Ethyl-(nor)-Pentedrone) compared to pentedrone.
|| This subjective effect breakdown is a stub.|
As such, it may contain incomplete or wrong information and is still in progress.
You can help by expanding it.
While the effects of hexen are often exaggerated, it is generally reported have more side effects when compared to mephedrone or NEP, which can lead to excessive redosing, sobriety delusions and toxicity, which can eventually lead to highly uncomfortable experiences. The effects of vaporized N-ethylhexedrone are reported to be much stronger and more euphoric with less side effects than when insufflated or taken orally, but extreme care should be taken with this route of administration due to the degree it promotes compulsive and reckless use.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
- Stimulation - N-Ethylhexedrone is reported to be be moderately to extremely stimulating and energetic.
- Spontaneous physical sensations - As with related cathininones, it is commonly reported that medium to high doses of N-ethylhexedrone can produce a pleasurable "body high" characterized by pleasant tingling sensations, which are stronger than that of amphetamine but weaker than a-PVP.
- Tactile enhancement
- Vasoconstriction - A number of reports indicate, N-ethylhexedrone can be considered slightly vasoconstrictive, though this has yet to be scientifically demonstrated.
- Increased blood pressure
- Increased heart rate
- Increased perspiration
- Appetite suppression
- Stamina enhancement
- Nausea - Mild to moderate nausea can occur at moderate to heavy dosages.
- Body odor alteration - This happens at a less consistent rate than with methamphetamine.
- Dry mouth
- Temporary erectile dysfunction -
- Teeth grinding - This component can be considered to be less intense when compared with that of MDMA and more similar to the teeth-grinding that can result from general cathinone use like a-PHP or NEP.
The headspace of N-ethylhexedrone is typically described as extreme mental stimulation accompanied by a powerful sense of euphoria.
- Thought acceleration
- Euphoria - This effect is usually not as powerful as with amphetamine or mephedrone.
- Analysis enhancement - This effect is mostly present in lower doses and is considered weak compared to other stimulant compounds. At high doses, it becomes overshadowed by euphoric stimulation.
- Immersion enhancement
- Focus enhancement - This component is most effective at low doses as anything higher will usually impair concentration due to the accompanying ephoria.
- Motivation enhancement
- Time compression
- Ego inflation
- Increased music appreciation
- Compulsive redosing - This is perhaps the most well-known aspect of this substance. This can result in unwanted binges of sometimes excessive amounts and a higher risk of addiction.
- N-ethylhexedrone's comedown is usually described as more slow and less dysphoric than the same effect found within MDMA or methamphetamine but harsher than that of NEP. The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational N-ethylhexedrone use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because N-ethylhexedrone has a very brief history of human usage.
Early anecdotal reports from those who have tried N-ethylhexedrone suggests that there do not seem to be any negative health effects attributed to simply trying it at low to moderate doses by itself and using it in a sparing and controlled fashion (but nothing can be completely guaranteed).
Some users have reported N-ethylhexedrone to be caustic to the nasal membrane when it is insufflated.
It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
As with other stimulants, the chronic use of N-ethylhexedrone can be considered moderately addictive with a high potential for abuse and seems to be readily liable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of N-ethylhexedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the total absence of further consumption). N-ethylhexedrone presents cross-tolerance with all noradrenergic and dopaminergic stimulants, meaning that after the consumption of N-ethylhexedrone all stimulants will have a reduced effect.
Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., anxiety andparanoia, hallucinations, or delusions). A review on treatment for (dextro)amphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.
Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- Stimulants - N-ethylhexedrone can be potentially highly dangerous in combination with other stimulants as it can unpredictably increase one's heart rate and blood pressure to dangerous levels.
- 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
- Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
- DXM - This combination may cause increased heart rate and panic attacks.
- MXE - Increased heart rate and blood pressure may occur.
- Tramadol - This combination can increase the risk of seizures.
- MDMA - The neurotoxic effects of MDMA are generally believed to be increased when combined with amphetamine and other stimulants.
- MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.
- Cocaine - This combination may increase strain on the heart to dangerous levels.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
- United Kingdom - N-Ethylhexedrone is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.
- Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
- Sweden - N-Ethylhexedrone was classified as an illegal narcotic in Sweden on June 21st, 2016.
- Liu, C., Jia, W., Li, T., Hua, Z., & Qian, Z. (n.d.). Identification and analytical characterization of nine synthetic cathinone derivatives N-ethylhexedrone, 4-Cl-pentedrone, 4-Cl--EAPP, propylone, N-ethylnorpentylone, 6-MeO-bk-MDMA, -PiHP, 4-Cl--PHP, and 4-F--PHP. https://doi.org/10.1002/dta.2136
- Treatment for amphetamine psychosis | 
- Treatment for amphetamine psychosis | 
- Hofmann FG (1983). A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects (2nd ed.). New York: Oxford University Press. p. 329. ISBN 9780195030570.
- Treatment for amphetamine psychosis | 
- Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
- United Kingdom. (2010). Misuse of Drugs Act 1971 (S.I. 2010/1207). London: The Stationery Office Limited. Retrieved February 9, 2018, from https://www.legislation.gov.uk/uksi/2010/1207/made
- 31 nya ämnen kan klassas som narkotika eller hälsofarlig vara | https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2016/juni/31-nya-amnen-kan-klassas-som-narkotika-eller-halsofarlig-vara/