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Not to be confused with N-Ethylhexedrone (Hexen).
Summary sheet: Hexedrone
Chemical Nomenclature
Common names Hexedrone
Systematic name 2-(methylamino)-1-phenylhexan-1-one
Class Membership
Psychoactive class Stimulant
Chemical class Cathinone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 30 mg
Light 50 - 70 mg
Common 70 - 100 mg
Strong 100 - 125 mg
Heavy 125 mg +
Total 1 - 4 hours
Onset 15 - 30 minutes
After effects 1 - 12 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Hexedrone is a novel synthetic stimulant of the cathinone class. It has been speculated to act as a norepinephrine-dopamine-reuptake-inhibitor (NDRI).

Subjective effects include stimulation, disinhibition, thought acceleration and euphoria.

Little is known about toxicity, addiction, and abuse potential of hexedrone. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with caution.


Hexedrone is a cathinone, which is closely related to amphetamines, but have a ß-substituted ketone group as well. Relative to regular cathinone, which can be found in the Khat plant, hexedrone consists of two added substitutions. At the R2 position, a n-Butyl substitution forms a hexan chain. The second substitution is a Methyl group, that's attached to the amine (R4), thus forming N-Methyl.


Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other cathinones such as pentedrone and others. Hexedrone most likely acts as both a dopamine and norepinephrine reuptake inhibitor. This allows dopamine and norepinephrine to build up within the brain, resulting in stimulating and euphoric effects.

The decreased potency, compared to both pentedrone as well as ethyl-hexedrone can be easily explained. Compared to pentedrone, there is a larger non-polar side chain. Ethyl-hexedrone has an ethyl group, instead of a methyl, which results in a significantly shifted electronegativity.

Subjective effects

Disclaimer: The effects listed below are cited from the subjective effect index, which is based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy degree of skepticism. It is worth noting that these effects will rarely (if ever) occur all at once, although higher doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects

After effects
Aftereffects (3).svg

Toxicity and harm potential

Since hexedrone has been insufficiently studied and most data consists of speculation and user experiences, one should be especially cautious when it comes to the risks and harm this substance may pose, especially in terms of seriouslong-term health hazards.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other stimulants, the chronic use of Hexedrone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of hexedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Hexedrone presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of Hexedrone all stimulants will have a reduced effect.

Legal issues


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Brazil: On September 7, 2018, all Cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.[1]
  • Germany: Hexedrone is controlled under the NpSG, as it is a derivative of 2-Phenethylamine. Production and sale is illegal. Possession and import, although illegal, is not penalized if intended for self-consumption.[2]
  • United Kingdom: Hexedrone is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.[3]

See also

External links


  1. New blanket ban on synthetic illegal drugs is approved (Portuguese) | http://portal.anvisa.gov.br/noticias/-/asset_publisher/FXrpx9qY7FbU/content/combate-a-drogas-ilicitas-sinteticas-fica-mais-facil
  2. https://www.gesetze-im-internet.de/npsg/anlage.html
  3. United Kingdom. (2010). Misuse of Drugs Act 1971 (S.I. 2010/1207). London: The Stationery Office Limited. Retrieved February 9, 2018, from https://www.legislation.gov.uk/uksi/2010/1207/made