Gaboxadol

Gaboxadol
Chemical Nomenclature
Common names	Gaboxadol, THIP
Substitutive name	Gaboxadol, tetrahydroisoxazolopyridine
Systematic name	4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol
Class Membership
Psychoactive class	Depressant / Hallucinogen
Chemical class	Tetrahydroisoxazole or Tetrahydroisoxazolopyridine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 5 - 10 mg Light 10 - 15 mg Common 15 - 30 mg Strong 30 - 45 mg Heavy 45 mg + Duration Total 2 - 5 minutes Onset 15 - 60 minutes Peak 1 - 2 hours Offset 1 - 3 minutes After effects 1 - 3 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: Gaboxadol

Gaboxadol (also knows as THIP, OV101 and LU-2-030) is a depressant substance of the isoxazole class that produces sedative, anxiolytic, hypnotic and distinct hallucinogenic effects. It is chemically related to muscimol, which is the primary alkaloid responsible for the psychoactive effects of amanita muscaria. It has been specifically developed alongside hundreds of other analogs to display more pronounced and selective therapeutic effects as well as a higher bioavailability than its parent compound muscimol.

It was first synthesized in 1977 by the Danish chemist Povl Krogsgaard-Larsen. Since then it was subject to numerous medical evaluations for potential applications as an anxiolytic and hypnotic as well as treating conditions such as Alzheimer's disease among others. It's latest attempt at clinical trials was for the treatment of insomnia, although the trials have been cancelled.

According to its pharmacological action, it is among a few hypnotic substances that do not negatively alter or suppress sleep and sleep architecture. It increases stage 4 deep sleep and simultaneously does not inhibit REM sleep, this is a trait currently unique to Gaboxadol and some related GABAergics such as pregabalin, GHB or cinazepam.

In high doses, Gaboxadol produces distinct deliriant effects but not in the manner of traditional deliriants. It can be categorized as a "GABAergic deliriant". It is said to have similar effects to muscimol and zolpidem.

Chemistry

Gaboxadol, also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a conformationally constrained derivative of the alkaloid muscimol.

Pharmacology

Gaboxadol acts on the GABA system, but in a different way from benzodiazepines and other GABAergic depressants. Lundbeck states that gaboxadol also increases deep sleep (stage 4).

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Sedation - Many users report mild to extreme sedation and even sleepiness or half-awake states while under the influence of Gaboxadol.
    • Perception of bodily heaviness
  • Stimulation - While most users report sedation and a lack of energy, some users also report a relatively intense stimulation.
  • Spontaneous physical sensations
    • Physical euphoria
  • Pain relief
  • Muscle relaxation
  • Muscle spasms
  • Nausea
  • Increased perspiration
  • Pupil constriction
  • Increased salivation

Visual effects

• Enhancements

  • Colour enhancement
  • Magnification
  • Visual acuity enhancement

  Suppression

  • Double vision
  • Visual haze
  • Visual acuity suppression

  Distortions

  • Colour shifting
  • After images
  • Tracers
  • Drifting
  • Depth perception distortions
  • Perspective distortions
  • Recursion

  Geometry

  Hallucinatory states

  • External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
  • Transformations
  • Peripheral information misinterpretation

Cognitive effects

• • Analysis enhancement
  • Consciousness disconnection: Many users report a distinct dissociation from their surroundings.
  • Cognitive euphoria - This results in feelings of physical euphoria which range between mild pleasure to powerfully all-encompassing bliss.
  • Decreased libido or Increased libido - Many users of Gaboxadol report to experience a noticeable decrease in libido while others report the opposite.
  • Dream potentiation - Many people fall asleep before the prominent effects take effect. These individuals report extremely vivid and often lucid dreams.
  • Empathy, love, and sociability enhancement - While this effect is less powerful than that of MDMA or MDA, it is still prominent.
  • Sleepiness - As a GABA_A agonist, Gaboxadol can make people extremely drowsy.
  • Unity and interconnectedness - While this effect is less powerful than that of MDMA or MDA, it is still prominent.
  • Existential self-realization
  • Immersion enhancement
  • Increased music appreciation
  • Analysis suppression
  • Introspection
  • Memory suppression

Auditory effects

• • Auditory distortion
  • Auditory hallucination - While a wide array of auditory hallucinations are possible, many users report hearing a strange, comforting, omnipresent humming sound.

Multi-sensory effects

• • Synesthesia

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

• Erowid Experience Vaults: Gaboxadol

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

Further information: Responsible use § Hallucinogens

Since Gaboxadol is a GABA_A agonist, it may be harmful to combine it with other GABAergic depressants such as benzodiazepines or barbiturates.

Gaboxadol is not known to be addictive or dependence-forming, and reports even show that desire to redose goes down with usage, though there is no research on this topic.

It is strongly recommended that one use harm reduction practices when using this substance.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

See also

• Responsible use
• Amanita muscaria
• Muscimol

External links

• Gaboxadol (Wikipedia)