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The general structure for a 2C-x compound

2C-x is the general name for the family of synthetic phenethylamines originally studied by Alexander Shulgin. Shulgin first synthesized most of the 2C-x chemicals in the 1970s and later published his findings in his book PiHKAL. The 2C-x chemicals vary in effect from being totally inactive to fully psychedelic.

List of 2C-x compunds

Compound R4 Structure
2C-B Br 2C-B.svg
2C-C Cl 2C-C.svg
2C-D CH3 2C-D.svg
2C-E CH2CH3 2C-E.svg
2C-H H 2C-H.svg
2C-I I 2C-I.svg
2C-iP CH(CH3)2 2C-iP.svg
2C-P CH2CH2CH3 2C-P.svg
2C-TFM CF3 2C-TFM.svg
2C-T SCH3 2C-T.svg
2C-T-2 SCH2CH3 2C-T-2.svg
2C-T-4 SCH(CH3)2 2C-T-4.svg
2C-T-7 SCH2CH2CH3 2C-T-7.svg
2C-T-21 SCH2CH2 2C-T-21.svg

Health effects, potential addiction and tolerance

The 2C-x chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective serotonin reuptake Inhibitor) or tricyclic antidepressants in general to avoid Serotonin Syndrome, a potentially life-threatening condition in which an abundance of serotonin is built up the body, causing many physical and cognitive health problems.

Legal status

  • Austria: The 2C-x family is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich) or the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
  • USA: In the US, most of the 2C-x chemicals are Schedule I under the American Food and Drug Administration Safety and Innovation Act of 2012 and the Federal Analogue Act.[1]
  • Australia: Australia has a blanket ban over all substituted phenethylamines including the entire 2C-X family.[2]
  • Switzerland: Most 2C-x drugs are illegal to possess, produce and sell.[3]
  • Canada: All 2C-x phenethylamines are schedule III in Canada. [4]
  • United Kingdom - Most of the 2C-x chemical class are Class A drugs in the United Kingdom as a result of the phenethylamine catch-all clause.[5]

See also

External links


  • Dean, B. V., Stellpflug, S. J., Burnett, A. M., & Engebretsen, K. M. (2013). 2C or not 2C: Phenethylamine Designer Drug Review. Journal of Medical Toxicology, 9(2), 172-178. https://doi.org/10.1007/s13181-013-0295-x