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Summary sheet: 2C-P
Chemical Nomenclature
Common names 2C-P
Substitutive name 2,5-Dimethoxy-4-propylphenethylamine
Systematic name 2-(2,5-Dimethoxy-4-propylphenyl)ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 1 - 3 mg
Light 2 - 6 mg
Common 6 - 10 mg
Strong 10 - 16 mg
Heavy 16 mg +
Total 10 - 20 hours
Onset 1 - 3 hours
Come up 2 - 4 hours
Peak 4 - 8 hours
Offset 3 - 6 hours
After effects 8 - 48 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

2,5-Dimethoxy-4-propylphenethylamine (commonly known as 2C-P) is a synthetic psychedelic of the phenethylamine chemical class that produces a long-lived, highly dose-sensitive array of psychedelic effects when administered. It is a member of the 2C-x family and was first synthesized and documented by Alexander Shulgin in his book PiHKAL ("Phenethylamines I Have Known and Loved")[1].

Along with other alkylated 2C-x substances like 2C-E, this compound is known particularly for its unusually long duration, powerful, sometimes overwhelming visuals, and intense "body load" (such as persisting nausea, muscle tension and general bodily discomfort). It is often described by users as a substance which is very similar to that of 2C-E yet distinct in its own effects.

Today, 2C-P is either used as a recreational substance or an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through online vendors.

This substance may be overly intense for those who are not already experienced with psychedelics due its often powerful effects and unusually long duration. For this reason, it is strongly recommended that one use harm reduction practices if choosing to use with this substance.


2C-P or 2,5-dimethoxy-4-propylphenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-P contains methoxy functional groups CH3O- attached to carbons R2 and R5 and a propyl chain attached to carbon R4 of the phenyl ring. 2C-P belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.[2]


Further information: Serotonergic psychedelic

2C-P's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how it results in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects

Visual effects

Cognitive effects

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational 2C-P use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-P is a research chemical with very little history of human usage.

Anecdotal reports from human users suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

2C-P is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-P are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-P presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-P all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume.

  • Tramadol - Tramadol lowers the seizure threshold[3] and psychedelics may act as triggers for seizures among those who are susceptible to them.[citation needed]
  • Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may result in an elevated risk of psychosis.[citation needed]
  • Lithium - Lithium is often used as treatment for bipolar disorder. There is a large body of reports that indicate combining it with psychedelics results in a highly elevated risk of seizures and psychosis, possibly owing to its glutaminergic and GABAergic effects.[citation needed]

Legal status

Possession and sale of 2C-P is unscheduled in most countries.

  • United Kingdom - 2C-P is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[4]
  • United States: 2C-P is a Schedule I drug.[5]
  • Austria: 2C-P is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich)[citation needed]
  • Denmark: 2C-P is added to the list of Schedule B controlled substances.[6]
  • Germany: On December 13, 2014 2C-P was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.[7]
  • Latvia: 2C-P is a Schedule I controlled substance.[8]
  • Switzerland: Possession, production and sale is illegal.[9]
  • China - As of October 2015 2C-P is a controlled substance in China.[10]
  • Canada: 2C-P would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[11]

See also

External links



  1. https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
  2. http://isomerdesign.com/PiHKAL/read.php?id=36
  3. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  4. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made
  5. http://www.justice.gov/ola/views-letters/112/093011-ltr-re-hr1254-synthetic-drug-control-act-2011.pdf
  6. https://www.retsinformation.dk/Forms/R0710.aspx?id=137169
  7. Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften (28. BtMÄndV)| http://www.buzer.de/gesetz/11392/a189949.htm
  8. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  9. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  10. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
  11. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28