|Summary sheet: 2C-P|
|Routes of Administration|
2,5-Dimethoxy-4-propylphenethylamine (commonly known as 2C-P) is a synthetic psychedelic of the phenethylamine chemical class that produces a long-lived, highly dose-sensitive array of psychedelic effects when administered. It is a member of the 2C-x family and was first synthesized and documented by Alexander Shulgin in his book PiHKAL ("Phenethylamines I Have Known and Loved").
Along with other alkylated 2C-x substances like 2C-E, this compound is known particularly for its unusually long duration, powerful, sometimes overwhelming visuals, and intense "body load" (such as persisting nausea, muscle tension and general bodily discomfort). It is often described by users as a substance which is very similar to that of 2C-E yet distinct in its own effects.
This substance may be overly intense for those who are not already experienced with psychedelics due its often powerful effects and unusually long duration. For this reason, it is strongly recommended that one use harm reduction practices if choosing to use with this substance.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Toxicity and harm potential
- 5 Legal status
- 6 See also
- 7 External links
- 8 References
2C-P or 2,5-dimethoxy-4-propylphenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-P contains methoxy functional groups CH3O- attached to carbons R2 and R5 and a propyl chain attached to carbon R4 of the phenyl ring. 2C-P belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.
2C-P's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how it results in the psychedelic experience continues to remain elusive.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
- Stimulation - In terms of its effects on the physical energy levels of the user 2C-P is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of 2C-B, 2C-I and other substances within the 2C-x family, being encouraged instead of forced.
- Spontaneous physical sensations - In comparison to 2C-E or 2C-B, the "body high" of 2C-P can be considered as mild although still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the "body high" experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. This is coupled by an equally intense yet slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person’s entire body as well as a slight warm glow that manifests itself much less consistently than the other two physical components. All of these are capable of becoming very physically euphoric.
- Tactile enhancement - This particular component is particularly prominent but capable of going in both pleasurable and uncomfortable directions. This can result in pleasurable tactile sensations but also enhances bodily aches and pains which one may not have previously been aware of to the point of extreme discomfort.
- Bodily control enhancement
- Temperature regulation suppression - In terms of its effects on body temperature 2C-P is capable of causing large increases and decreases in temperature in a dose dependent manner. This can become extremely uncomfortable if not dangerous at larger doses due to the fever-like delirium it can induce.
- Increased heart rate
- Increased blood pressure
- Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the user has vomited or gradually fades by itself as the peak sets in.
- Increased libido - A commonly felt physical component of the 2C-P trip is the way in which it heightens and enhances sexual arousal. When experienced, this sensation is not overwhelming or out of control but simply remains something that the user is constantly aware of. If sexual activities of any kind are engaged in, they are found to be immensely more pleasurable beyond anything that could be possible sober with orgasm becoming difficult to reach but completely possible to obtain. When obtained, the orgasm itself is capable of temporarily increasing the effects of the drug. This is most commonly experienced as visual effects dramatically increasing in a short yet powerful burst.
- Pupil dilation
- Teeth grinding
- Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style.
- After images
- Symmetrical texture repetition
- Colour shifting
- Scenery slicing
- Depth perception distortions
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel that at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A. There seems to be visual geometry that is distinct from 2C-E, psilocin and ayahuasca and can be described as faster moving and more intense in proportion to cognitive and physical effects than 2C-E.
2C-P produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-P is extremely high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- Unspeakable horrors - This is an effect that is typically associated with deliriants rather than psychedelics. Based on anecdotal reports, they only tend to occur at higher doses and are likely a result of the pronounced temperature increasing properties this substance has compared to other 2C-x and psychedelics, which can lend readily to delirium-like states.
The cognitive effects of 2C-P have been described as both insightful and relatively normal in their thought processes up to moderate dosages, after which their confusing, and disorienting effects can increase considerably.
The total sum of these cognitive components regardless of the setting generally includes:
- Analysis enhancement
- Conceptual thinking
- Creativity enhancement
- Autonomous voice communication
- Emotion enhancement
- Immersion enhancement
- Increased music appreciation
- Memory suppression
- Multiple thought streams
- Novelty enhancement
- Personal bias suppression
- Personal meaning enhancement
- Thought acceleration
- Thought loops
- Time distortion
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational 2C-P use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-P is a research chemical with very little history of human usage.
Anecdotal reports from human users suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
2C-P is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 2C-P are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-P presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-P all psychedelics will have a reduced effect.
Although many psychoactive substances are safe to use on their own, they can become dangerous or even life-threatening when taken with other substances. The list below contains some potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses but still increase the possibility of injury of death. Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.
- Tramadol - Tramadol lowers the seizure threshold and psychedelics may act as triggers for seizures among those who are susceptible to them.
- Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may result in an elevated risk of psychosis.
- Lithium - Lithium is often used as treatment for bipolar disorder. There is a large body of reports that indicate combining it with psychedelics results in a highly elevated risk of seizures and psychosis, possibly owing to its glutaminergic and GABAergic effects.
Possession and sale of 2C-P is unscheduled in most countries.
- United Kingdom - 2C-P is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
- United States: 2C-P is a Schedule I drug.
- Austria: 2C-P is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich)
- Denmark: 2C-P is added to the list of Schedule B controlled substances.
- Germany: On December 13, 2014 2C-P was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.
- Latvia: 2C-P is a Schedule I controlled substance.
- Switzerland: Possession, production and sale is illegal.
- China - As of October 2015 2C-P is a controlled substance in China.
- Canada: 2C-P would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
- https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
- Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
- United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made
- Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften (28. BtMÄndV)| http://www.buzer.de/gesetz/11392/a189949.htm
- Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28