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Summary sheet: 25E-NBOH

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4-Ethyl-2,5-dimethoxy-(N-(2-hydroxybenzyl))phenethylamine (also known as 25E-NBOH and 2C-E-NBOH) is a closely related analog of 25E-NBOMe. 25E-NBOH is a synthetic psychedelic substance of the phenethylamine chemical class and is reported to share most of its properties with the exception of a moderately reduced potency and a shorter duration with 25E-NBOMe. Phenethylamine's produce an array of visually-dominant and stimulating psychedelic effects when administered.

25E-NBOH is a derivative of the hallucinogen 2C-E. It was first developed by Martin Hansen at the University of Copenhagen in 2010 as a brain imaging agent,[1][2] but has subsequently been sold as a designer drug, first being identified in Brazil in 2018 on seized blotter paper, as well as in several European countries.[3] Although it is unknown exactly how 25E-NBOH exerts its effects it is believed to act by binding to serotonin receptors in the brain. Related substances of the NBOH family include: 25B, 25C, and 25I, all of which were identified in 2016 by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).[4]

Similar to other known psychedelics, compounds of the NBOH family are not orally active and should be administered sublingually by placing and holding it in one's mouth and allowing it to absorb over a period of 15-25 minutes.

Subjective effects include open and closed-eye visuals, time distortion, enhanced introspection, ego loss, stimulation, and euphoria. User reports characterize 25E-NBOH as a clear headed, dose-sensitive psychedelic that is capable of producing strong visual distortions along with a significant "body load". 25E's body load manifests itself through vasoconstriction. Users describe the body load as making their muscles very sore and many take supplements to counteract these effects.

Little to no research has been done on the effects of 25E-NBOH on humans or animals. However, being an analogue of the NBOMe class it is suspected that it may have a similar safety profile. When using this substance it is highly advised to use harm reduction practices.

History and culture

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25E-NBOH was first introduced to the scientific community in 2010 by Martin Hansen as a brain imaging agent.[2] It wasn't until 2017 that the substance found its way onto seized blotter paper in Brazil.[3] It is likely that the substance has been used prior to 2017, but their is a lack of hard evidence. Today, 25E-NBOH is used as a cost effective alternative to LSD or passed off as LSD.



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25E-NBOH's psychedelic effects are believed to be mediated by its binding to the 5-HT2A and 5-HT2C receptors as an agonist.[5] Information regarding the pharmacological properties of 25E-NBOH is still scarce, but its action is similar to that of the other serotonergic psychedelics.

Subjective effects

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Visual effects

Cognitive effects

Multi-sensory effects

Experience reports

25E-NBOH's use is not widespread and there are currently 0 experience reports which describe the effects of this substance in our experience index. Additional experience reports can be found here:

Toxicity and harm potential


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Note: Always conduct independent research and use harm reduction practices if using this substance.

25E-NBOH like other classical psychedelics is not believed to have any long term safety concerns. Anecdotal reports suggest that 25E-NBOH is non-habit forming. It is recommended that a break is taken between use of this or other psychedelics to allow for tolerance to reset and the body to recover.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

There is no known lethal dosage for 25E-NBOH however, this does not mean it is impossible to die from its ingestion.

Tolerance and addiction potential

Although no formal studies have been conducted, it is not unreasonable to assume that like psychedelics in general, 25E-NBOH is not habit-forming and that the desire to use it can actually decrease with use.

Tolerance to the effects of 25E-NBOH is built almost immediately after ingestion. After that, it takes about 1-2 days for the tolerance to be reduced to half and 2-4 days to be back at baseline (in the absence of further consumption). 25E-NBOH presents cross-tolerance with all psychedelics but not evenly, meaning that after the consumption of 25E-NBOH, some psychedelics will have significant reduced effects while some others will only be slighly affected.

Dangerous interactions


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Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Drug interactions

  • Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 25E-NBOH. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
  • Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.[citation needed]
  • Tramadol - Tramadol is well-documented to lower the seizure threshold and psychedelics may act to trigger seizures in susceptible individuals.[citation needed]

Condition interactions

  • Bipolar disorder - Those effected by Bipolar disorder are at a greater risk of having an episode or a psychotic break and are strongly advised not to use this substance.
  • Schizoaffective disorder - Those effected by Schizoaffective disorder are at a greater risk of having an episode or a psychotic break and are strongly advised not to use this substance.

Legal status


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  • United States: 25E-NBOH is not regulated under the Controlled Substances Act of 1970,[6] however it's structurally similar to substances from the NBOMe class. Meaning that 25E-NBOH falls under the the Federal Analogue Act of 1986. This considers it as s Schedule I controlled substance, making illegal to manufacture, buy, possess, process, or distribute without a license from the Drug Enforcement Administration (DEA).[7]

See also

External links

(List along order below)


  1. Hansen, M. (2010). "Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain". doi:10.13140/RG.2.2.33671.14245. 
  2. 2.0 2.1 Ettrup, A., Hansen, M., Santini, M. A., Paine, J., Gillings, N., Palner, M., Lehel, S., Herth, M. M., Madsen, J., Kristensen, J., Begtrup, M., Knudsen, G. M. (April 2011). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681–693. doi:10.1007/s00259-010-1686-8. ISSN 1619-7070. 
  3. 3.0 3.1 Machado, Y., Coelho Neto, J., Lordeiro, R. A., Alves, R. B., Piccin, E. (January 2020). "Identification of new NBOH drugs in seized blotter papers: 25B-NBOH, 25C-NBOH, and 25E-NBOH". Forensic Toxicology. 38 (1): 203–215. doi:10.1007/s11419-019-00509-7. ISSN 1860-8965. 
  4. European Monitoring Centre for Drugs and Drug Addiction., European Union Agency for Law Enforcement Cooperation. (2017). EMCDDA–Europol 2016 annual report on the implementation of Council Decision 2005/387/JHA: in accordance with Article 10 of Council Decision 2005/387/JHA on the information exchange, risk assessment and control of new psychoactive substances. Publications Office. 
  5. Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H., Kristensen, J. L. (19 March 2014). "Synthesis and Structure–Activity Relationships of N -Benzyl Phenethylamines as 5-HT 2A/2C Agonists". ACS Chemical Neuroscience. 5 (3): 243–249. doi:10.1021/cn400216u. ISSN 1948-7193. 
  6. Drug control: Highlights of P.L. 99-570, Anti Drug Abuse Act of 1986: (drug-related provisions only) (1986). bill.
  7. "Controlled Substances: by CSA Schedule" (PDF). U.S. Department of Justice. August 21, 2019. p. 1.