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|Summary sheet: DET|
|Common names||Diethyltryptamine, DET|
|Routes of Administration|
Diethyltryptamine (also known as N,N-DET or DET) is a synthetic psychedelic tryptamine and a close structural analog of DMT (Dimethyltryptamine). It is extremely uncommon and has little history of human usage.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Toxicity and harm potential
- 5 Legal status
- 6 See also
- 7 External links
- 8 References
DET, or N,N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. DMT contains two ethyl groups CH2CH3- bound to the terminal amine RN of its tryptamine backbone. DET has many substituted analogues such as 4-HO-DET ("ethocin").
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other tryptamine psychedelics such as psilocin and DMT. With this in mind, DET is thought to act as an 5-HT2A partial agonist.
Unlike DMT, the ethyl groups add protection against the monoamine oxidase enzyme system, allowing DET to be orally active, while DMT is not.
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
- Drifting (melting, breathing, morphing and flowing)
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
- After images
- Brightness alteration
There are currently 0 anecdotal reports which describe the effects of this compound within our experience index.
Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational DET has not been studied in any scientific context and the exact toxic dose is unknown. This is because DET is a research chemical with a limited history of human usage. However, it is presumed to have a similar toxicity profile as DMT due to similarities in their chemical structure.
Anecdotal reports from those who have tried DET suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
Tolerance and addiction potential
Although no formal studies have been conducted, it is believed that DET is not habit-forming and the desire to use it can actually decrease with use.
Tolerance to the effects of DET is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). DET presents cross-tolerance with all psychedelics, meaning that after the consumption of DET all psychedelics will have a reduced effect.
Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from Tripsit.
- Lithium - Lithium is often used as treatment for bipolar disorder. It can dangerously amplify the intensity of psychedelics and has been strongly linked with psychosis and seizures. The causes are poorly understood, but it may be due to its glutaminergic and GABAergic properties.
- Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.
- Tramadol - Tramadol lowers the seizure threshold and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.
- Germany: Possession, production and sale is illegal.
- United States: DET is a Schedule I drug.
- United Kingdom: DET is a Class A drug.
- New Zealand: DET is a Class A controlled drug in New Zealand.
- Italy: DET is a Schedule I drug.
- Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
- BtMG Anlage I | https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html
- Drug Enforcement Administration | https://www.deadiversion.usdoj.gov/schedules/orangebook/e_cs_sched.pdf
- Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I