Diarylethylamine

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The general structure for a diarylethylamine

Diarylethylamines are a class of psychoactive substances that produce dissociative effects when administered. Their characteristic effects are similar to those of arylcyclohexylamine dissociatives like PCP or ketamine, although they differ in their chemical structure.

Diarylethylamines are examples of contemporary designer drugs specifically chosen to mimic and/or replace the functional and structural features of commonly used illicit substances. They have been marketed on the online research chemicals market as a replacement for MXE and other dissociatives.

Very little is known about the human pharmacology, metabolism, and toxicity of these compounds. Many reports suggest that they may pose different and more pronounced risks than traditional dissociatives.

Pharmacology

NMDAR binding affinities for five target 1,2-diphenylethylamines and reference compounds[1]
Compound IC50 ± SEM (nM) Ki ± SEM (nM)
PCP[2] 91 ± 1.3 57.9 ± 0.8
Ketamine 508.5 ± 30.1 323.9 ± 19.2
Memantine 594.2 ± 41.3 378.4 ± 26.3
(+)-MK-801 4.1 ± 1.6 2.5 ± 1.0
DPH (Diphenidine) 28.6 ± 3.5 18.2 ± 2.2
2-MXP (Methoxphenidine) 56.5 ± 5.8 36.0 ± 3.7
3-MXP 30.3 ± 2.6 19.3 ± 1.7
4-MXP 723.8 ± 69.9 461.0 ± 44.5
2-Cl-DPH 14.6 ± 2.1 9.3 ± 1.3
NMDAR binding affinites determined using [3H]-(+)-MK-801 in rat forebrain.[3]

Examples

See also

Literature

  • Wallach, J., Kang, H., Colestock, T., Morris, H., Bortolotto, Z. A., Collingridge, G. L., ... & Adejare, A. (2016). Pharmacological investigations of the dissociative ‘legal highs’ diphenidine, methoxphenidine and analogues. PLoS One, 11(6), e0157021. https://doi.org/10.1371/journal.pone.0157021
  • Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620

References