Allylescaline

From PsychonautWiki
Jump to: navigation, search
Allylescaline
Allylescaline.svg
Chemical Nomenclature
Common names Allylescaline, AL
Substitutive name 4-allyloxy-3,5-dimethoxyphenethylamine
Systematic name 4-Allyloxy-3,5-dimethoxyphenethylamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 15 - 20 mg
Light 20 - 30 mg
Common 30 - 40 mg
Strong 40 - 60 mg
Heavy 60 mg +
Duration
Total 8 - 12 hours
Onset 45 - 240 minutes









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: Allylescaline

Allylescaline, AL or 4-allyloxy-3,5-dimethoxyphenethylamine is a psychedelic drug and entheogen of the phenethylamine class of compounds. It is relatively uncommon and has little to no history of human usage. Very little data exists about the pharmacological properties, metabolism, and toxicity of allylescaline.

The effects of this compound were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 20 – 35 mg orally and describes the duration of action to be 8 - 12 hours.[1]

Chemistry

Allylescaline, or 4-allyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. Escaline contains two methoxy functional groups CH3O- which are attached to carbons R3, and R5 and an additional allyloxy group at carbon R4 of the phenyl ring. Allylescaline is the 4-allyloxy analog of mescaline.

Pharmacology

Further information: Serotonergic psychedelic

Allylescaline acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from allylescaline's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Metacogghjgjvghnition.png
This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

You can help by expanding it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.


Toxicity and harm potential

The toxicity and long-term health effects of recreational allylescaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because allylescaline is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried allylescaline suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Allylescaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of allylescaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Allylescaline presents cross-tolerance with all psychedelics, meaning that after the consumption of allylescaline all psychedelics will have a reduced effect.

Legal issues

Handcuffs-300px.png

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[2]

See also

External links

References

  1. https://www.erowid.org/library/books_online/pihkal/pihkal002.shtml | Allylescaline (TiHKAL)
  2. Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted