|Summary sheet: Myristicin|
|Substitutive name||Myristicin, 3-methoxy,4,5-methylenedioxy-allylbenzene|
|Chemical class||Phenylpropene / MDxx|
|Routes of Administration|
Myristicin is a naturally-occurring deliriant substance of the phenylpropene class. It is present in small amounts in the essential oil of nutmeg and, to a lesser extent, in other spices such as parsley and dill. It acts as an anticholinergic, and has been shown to act on the endocannabinoid system.
Myristicin, along with elemicin, is thought to be the main psychoactive constituent of nutmeg. Additionally, myristicin is the traditional precursor for the psychedelic and empathogenic drug MMDA.
Nutmeg was reported to induce hallucinogenic effects, such as visual distortions and paranoid ideation. In the reports, nutmeg intoxication took several hours before maximum effect was reached. Effects and after-effects lasted up to several days. Raw nutmeg consists of 5-15% essential oil by mass. 4-8.5% of nutmeg essential oil, or 0.2-1.3% of raw nutmeg, is myristicin. One study found 20 grams of nutmeg to contain 210 mg myristicin.
It should be noted that the dosage listed on this page assumes that one is using nutmeg powder and not pure myristicin, as this is extremely uncommon. It is highly advised to use harm reduction practices if using this substance.
Myristicin, also known as 3-methoxy,4,5-methylenedioxyallylbenzene, is a naturally occurring substance which belongs to a chemical class known as the phenylpropenes. It features a methylenedioxy ring at carbons R4 and R5 of the benzene ring. The benzene ring is also substituted with a separate methoxy group at the R3 carbon, and an allyl chain at R6 to make the main phenylpropene group.
In 1963, Alexander Shulgin speculated myristicin could be metabolized to MMDA, a psychoactive drug related to MDA, in the liver. This, however, is unlikely due to the fact that no amphetamine metabolites were found in urine after the ingestion of myristicin. It is believed that myristicin is an anticholinergic, since, in overdose, it produces effects similar to anticholinergics, but the exact mechanism of action has not been established. Myristicin is also found to be a serotonin receptor antagonist, while simultaneously acting as a weak MAO inhibitor.
Elemicin is found in nutmeg alongside myristicin and contributes to its hallucinogenic effects. Elemicin is likely to have similar effects to myristicin. It is also the traditional precursor in synthesizing the alkaloid mescaline.
|This subjective effects section is a stub.|
As such, it is still in progress and may contain incomplete or wrong information.
You can help by expanding or correcting it.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death.
In comparison to datura or diphenhydramine, its effects tend to be milder and, depending on the dosage, even be considered pleasant and euphoric. It has unique effects compared to other deliriants or hallucinogens. It also has a long, smooth and enjoyable come-up, where the effects build in a similar manner to cannabis. In addition to this, cannabis like effects throughout the duration have been reported among users of the substance which is likely due to the action of it on cannabinoid receptors. With higher doses, however, the deliriant effects become more pronounced.
The physical effects of myristicin are usually described as mild and tolerable, which makes them different from other deliriants. They can be uncomfortable or pleasurable, depending on the dosage. These are described below and generally include:
- Difficulty urinating and Frequent urination - This can be described as a feeling of concrete blocking the urethra, painfully conflicting with a frequent need to urinate.
- Abnormal heartbeat
- Dehydration - Nutmeg causes a lot of dehydration and dehydration is proven to cause deliriant effects and delirium.
- Perception of bodily heaviness
- Pupil dilation
- Spontaneous tactile sensations
- Tactile enhancement or Tactile suppression
- Tactile hallucination
Myristicin can both enhance and suppress visual stimuli depending on many factors that include but are not limited to; age, genetic factors, dehydration, combining nutmeg with other spices, sleep deprivation and placebo. Some of the visual effects of nutmeg include:
- Visual acuity suppression - This effect can result in blurry vision. It sometimes can last for days after the trip itself.
- Double vision
- Pattern recognition suppression
- After images
- Drifting Breathing, objects having their size altered
- Environmental patterning You may see lines around and inside objects, essentially everything will have structure - You may see eyes like you would on psilocybin but to a lesser intensity
- Tracers - Tracers can reach up to intense (3.) level.
- Frame rate suppression Combined with time distortion nutmeg could make movies and videos feel more choppy. At higher doses this effect becomes stronger
- Pattern recognition enhancement You may see eyes around you in trees and holes, Mandala like patterns, more similar in nature to psilocybin than LSD, rarely achieved by using just nutmeg itself
- Colour enhancement visuals might be slightly more vibrant and objects might have a glow around them
- Geometry while very uncommon on nutmeg by itself , it is possible when combined with other spices or psychedelics . The patterns and geometry of nutmeg is more in nature of what is experienced on DMT than other drugs, but way way less intense . You may see lines on objects and potentially organic geometry
Myristicin is moderately efficient at inducing delirious hallucinations which can be broken into the categories described below:
- External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other classes of hallucinogen, this effect occurs more frequently than that of any other at moderate to heavy doses and is the defining feature of the experience. It can be comprehensively described through its variations as delirious in believability, autonomous in controllability and solid in style. The most common themes for these hallucinations include those of everyday occurrences such as smoking phantom cigarettes, talking to people who are not there, insects, and sinister, nightmarish experiences.
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other classes of hallucinogen, this effect occurs briefly and spontaneously at moderate doses but becomes progressively extended in its occurrence and duration proportional to dosage before eventually becoming all-encompassing. It can be comprehensively described through its variations as delirious in believability, interactive in style, equal in new experiences and memory replays in content, autonomous in controllability and solid in style.
- Peripheral information misinterpretation
- Shadow people Nutmeg is rarely reported to induce full on psychosis like delirium with shadow figures but at higher doses combined with dehydration it is possible
The cognitive effects of myristicin are described by many as mildly euphoric, but can also be dysphoric throughout the trip, primarily consisting of moderate paranoia. It can also be confusing and disorienting. Myristicin contains unique cognitive effects found almost exclusively in the deliriant class.
The most prominent of these effects include:
- Anxiety at higher doses or Anxiety suppression on lower doses with the correct mindset
- Motivation enhancement This effect usually appears on the comedown or as a aftereffect
- Emotion enhancement This effect can enhance both negative and positive feelings, which means set and setting can drastically alter the nutmeg experience
- Analysis suppression
- Language suppression
- Increased music appreciation
- Paranoia This effect is common at high doses
- PsychosisThis effect is common at high or strong doses
- Suggestibility enhancement
- Time distortionTime usually will feel slower
- Thought deceleration
- Thought disorganization
Myristicin is found in nutmeg, nutmeg essential oil and to a lesser extent in parsley, dill and other plants.
Ground nutmeg powder
This is the most common form in which myristicin is sold, and it can be found in almost any supermarket as a spice.
It is worth noting that anecdotal reports suggest no clear guide on dosaging in this form. Myristicin degrades once it has been ground up, therefore it is impossible to know the potency of the powder, and the longer that the nutmeg stays as a powder, the weaker the myristicin content. When using store-bought nutmeg, the dose for oral consumption is generally considered to be:
- Light: 5 - 15g
- Common: 15 - 20g
- Strong: 20 - 30g
- Heavy: 30g+
Whole nutmeg is also sold in most places as a spice.
- Light: 2 - 5g
- Common: 5 - 15g
- Strong: 15 - 20g
- Heavy: 20g+
Myristicin can be extracted from nutmeg powder by fractional distillation. When using pure myristicin, the dose for oral consumption is generally considered to be:
- Light: 50 - 200mg
- Common: 200 - 500mg
- Strong: 500 - 800mg
- Heavy: 800mg+
Anecdotal reports which describe the effects of this compound within our experience index include:
- Experience:3 drops of cinnamon bark oil/ 5 drops of german chamomile oil/ 2mL of nutmeg oil in lecithin - experiments with nutmeg oil
- Experience:4 tablespoons of Nutmeg
- Experience:Nutmeg (8 teaspoons) - My Mom Introduces Me To Genesis and Other Things
Additional experience reports can be found here:
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
Myristicin is neurotoxic and can be fatal in extremely high doses.
Although many psychoactive substances are reasonably safe to use on their own, they can suddenly become dangerous or even life-threatening when combined with other substances. The following list includes some known dangerous combinations (although it is not guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- Stimulants - Nutmeg puts a fair amount of strain on the cardiovascular system, adding stimulant drugs to the mix would only make things worse.
- Alcohol - Anecdotal reports suggest that small/medium amounts of alcohol can create some positive effects, however respiratory depression is a risk. Large amounts of alcohol should not be combined with myristicin in any circumstance.
- Opioids - Large amounts of opioids can lead to respiratory depression when taken with myristicin.
- DXM - While it is possible to take a very small dose of DXM with myristicin, it is highly risky and is generally seen to be dangerous.
- DPH - DPH is cardio toxic, combining it with myristicin could be fatal.
- Depressants - Respiratory depression is a risk when combining with depressant drugs, while a few anecdotal reports have shown little side effects, it is generally recommended against.
- Serotonin releasers such as MDMA, 4-FA, methamphetamine, methylone and αMT will cause serotonin syndrome. If planning to combine these two, proceed with great caution.
Tolerance and addiction potential
Myristicin is not known to be addictive and the desire to use it can actually decrease with use. It is mostly self-regulating.
Information regarding tolerance is unknown.
Myristicin and nutmeg are both unscheduled in nearly all parts of the world and are commonly bought in form of either ground spice, essential oil or as whole nuts. Nutmeg is legal to purchase as a spice in the United Kingdom, however using it recreationally or extracting the myristicin is against the law.
- McKenna, A., Nordt, S. P., & Ryan, J. (2004). Acute nutmeg poisoning. European Journal of Emergency Medicine, 11(4), 240-241. https://doi.org/10.1097/01.mej.0000127649.69328.a5
- Abernethy, M. K., & Becker, L. B. (1992). Acute nutmeg intoxication. The American journal of emergency medicine, 10(5), 429-430. https://doi.org/10.1016/0735-6757(92)90069-A
- Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15795093