Classical psychedelics

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Classical psychedelics (or classic psychedelics) refers to the most common, recognizable, and historically significant psychedelic substances. They generally include:

A common feature of classical psychedelics is that they act as (partial) agonists at the serotonin 5-HT2A receptor, which is abundant in specific regions of the human brain.[1][2]

Classical psychedelics may be distinguished from novel psychedelics, which are generally psychedelics discovered after the 1970s. These include relatively older and well-tested substances like 2C-B as well as highly novel compounds like the 25x-NBOMe series, which were developed as neurochemical probes.

Furthermore, they are considered to have excellent safety profiles compared to most psychoactive substances.[citation needed] They are non-addictive and have low toxicity.[citation needed] However, adverse psychological reactions like severe anxiety, paranoia, delusions, mania, and psychosis are always possible, especially in individuals susceptible to mental disorders. As a result, harm reduction practices are advised.

See also


  1. Carhart-Harris RL, Leech R, Hellyer PJ, Shanahan M, Feilding A, Tagliazucchi E, Chialvo DR and Nutt D (2014), The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Front. Hum. Neurosci. 8:20. (Open Access)
  2. Glennon, R. A., Titeler, M., and McKenney, J. D. (1984). Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sci. 35, 2505–2511.