3C-E

From PsychonautWiki
Jump to: navigation, search
Yellow-warning-sign1.svg

This page has not been approved by the PsychonautWiki administrators.

It may potentially contain incorrect information, particularly regarding that of dosage, duration, subjective effects, toxicity and other risks.

Proofread.png

This article requires proofreading.

As such, it may contain incorrect grammar, spelling, or punctuation.

Summary sheet: 3C-E
3C-E
Molecular structure of 3C-E
3C-E.svg
Chemical Nomenclature
Common names 3C-E, 3C-Escaline
Substitutive name 3,5-Dimethoxy-4-ethoxyamphetamine
Systematic name 1-(4-Ethoxy-3,5-dimethoxyphenyl)propan-2-amine
Class Membership
Psychoactive class Psychedelic
Chemical class Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 20 - 30 mg
Light 30 - 40 mg
Common 40 - 60 mg
Strong 60 - 80 mg
Heavy 80 mg+
Duration
Total 10 - 16 hours
Onset 1 - 2 hours
Peak 4 - 8 hours
Offset 3 - 6 hours
After effects 3 - 6 hours



Insufflated
Dosage
Threshold 15 - 20 mg
Light 20 - 35 mg
Common 35 - 60 mg
Strong 60 - 70 mg
Heavy 70 mg+
Duration
Onset 5 - 90 minutes
Peak 4 - 7 hours
Offset 2 - 5 hours
After effects 3 - 5 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

3,5-Dimethoxy-4-ethoxyamphetamine (commonly known as 3C-E or 3C-Escaline) is a synthetic psychedelic compound of the amphetamine chemical class. Although its name suggests it may be related to the 2C-x family, this is not the case since it is the 3-Carbon analog of escaline

It was presumably first synthesized by Alexander Shulgin and published in his book PiHKAL in 1991.

Today, 3C-E is used for recreational and research purposes, and exclusively distributed as a gray area research chemical by online vendors. Very little is known about its effects besides its strong body high and weak visuals.

Chemistry

3C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. 3C-E contains methoxy functional groups OCH3 attached to carbons R3 and R5 and an ethoxy chain OCH2CH3 attached to carbon R4 of the phenyl ring.

3C-E is the amphetamine analog of escaline.

Pharmacology

Further information: Serotonergic psychedelic

3C-E's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects
Child.svg

Visual effects
Eye.svg

Cognitive effects
User.svg

Multi-sensory effects
Gears.svg

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index.

Toxicity and harm potential

Ambulance2.png

This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
We also recommend that you practice diligent independent research and the most thorough harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 3C-E is a research chemical with very little history of human usage.

Anecdotal evidence from people within the community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

3C-E is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 3C-E is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 3C-E presents cross-tolerance with all psychedelics, meaning that after the consumption of 3C-E all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legality

Handcuffs-300px.png

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[2]
  • United States: 3C-E is technically not scheduled in the United States, but could be considered an analog of mescaline and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.

See also

External links

References

Question book-new.svg

This article does not cite enough references.

You can help by adding some.

  1. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  2. Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted