|Summary sheet: Proscaline|
|Routes of Administration|
4-Propyloxy-3,5-dimethoxyphenethylamine (commonly known as Proscaline) is a synthetic psychedelic substance of the phenethylamine chemical class that produces modified mescaline-like hallucinogenic effects when administered. It has structural and pharmacological properties similar to its parent drug mescaline as well as to its analogs such as isoproscaline, escaline and allylescaline.
The synthesis of proscaline was first published by David E. Nichols in 1977. Around the same time, Alexander Shulgin sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of mescaline. Shulgin later documented Proscaline in his 1991 book "PiHKAL: A Chemical Love Story".
Today, proscaline is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. It is relatively obscure and has only a short history of human use.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Toxicity and harm potential
- 5 Legal issues
- 6 See also
- 7 External links
- 8 References
Proscaline, or 3,5-dimethoxy-4-propyloxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. Proscaline contains two methoxy functional groups CH3O- which are attached to carbons R3 and R5 as well as an additional propyloxy group at carbon R4 of the phenyl ring. Proscaline is the 4-propyloxy analog of mescaline, which means it has one additional carbon at the alkyloxy group than escaline, another closely related mescaline analog.
Proscaline's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
|This subjective effects section is a stub.|
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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
- Drifting (melting, breathing, morphing and flowing)
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
- After images
- Brightness alteration
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational proscaline use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried proscaline within the psychedelic community suggests that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
Proscaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of proscaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). proscaline presents cross-tolerance with all psychedelics, meaning that after the consumption of proscaline all psychedelics will have a reduced effect.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
- United States: Proscaline is uncontrolled in the United States, but could be considered an analogue of mescaline under the Federal Analogue Act.
- United Kingdom: Proscaline is a Class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.
- Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml
- "Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.
- Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf