Proscaline

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Summary sheet: Proscaline
Proscaline
Proscaline.svg
Chemical Nomenclature
Common names Proscaline
Substitutive name 4-propyloxy-3,5-dimethoxyphenethylamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 10 - 15 mg
Light 15 - 30 mg
Common 30 - 40 mg
Strong 40 - 60 mg
Heavy 60 mg +
Duration
Total 8 - 12 hours
Onset 30 - 60 minutes
After effects 3 - 5 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

4-Propyloxy-3,5-dimethoxyphenethylamine (commonly known as Proscaline) is a synthetic psychedelic substance of the phenethylamine chemical class that produces modified mescaline-like hallucinogenic effects when administered.[1] It has structural and pharmacological properties similar to its parent drug mescaline as well as to its analogs such as isoproscaline, escaline and allylescaline.

The synthesis of proscaline was first published by David E. Nichols in 1977.[2] Around the same time, Alexander Shulgin sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of mescaline.[3] Shulgin later documented Proscaline in his 1991 book "PiHKAL: A Chemical Love Story".

Today, proscaline is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. It is relatively obscure and has only a short history of human use.

Chemistry

Proscaline, or 3,5-dimethoxy-4-propyloxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. Proscaline contains two methoxy functional groups CH3O- which are attached to carbons R3 and R5 as well as an additional propyloxy group at carbon R4 of the phenyl ring. Proscaline is the 4-propyloxy analog of mescaline, which means it has one additional carbon at the alkyloxy group than escaline, another closely related mescaline analog.

Pharmacology

Further information: Serotonergic psychedelic

Proscaline's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

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This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects

Cognitive effects

Visual effects

Enhancements

Distortions

Geometry

Hallucinatory states

Auditory effects

Toxicity and harm potential

The toxicity and long-term health effects of recreational proscaline use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried proscaline within the psychedelic community suggests that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

Proscaline is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of proscaline are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). proscaline presents cross-tolerance with all psychedelics, meaning that after the consumption of proscaline all psychedelics will have a reduced effect.

Legal issues

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • United States: Proscaline is uncontrolled in the United States, but could be considered an analog of mescaline under the Federal Analog Act.[citation needed]
  • United Kingdom: Proscaline is a Class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.[citation needed]

See also

External links

References

  1. Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml
  2. "Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.
  3. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf