Pramiracetam

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Summary sheet: Pramiracetam
Pramiracetam
Pramiracetam.svg
Chemical Nomenclature
Common names Pramiracetam
Systematic name N-[2-(Diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide
Class Membership
Psychoactive class Nootropic
Chemical class Racetam
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 100 - 250 mg
Light 250 - 500 mg
Common 500 - 800 mg
Strong 800 - 1200 mg
Heavy 1200 mg +
Duration
Total 4 - 7 hours
Onset 30 - 90 minutes









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Pramiracetam (also known by the brand-name Pramistar) is a central nervous system stimulant and nootropic agent belonging to the racetam family of drugs. It is marketed as a prescription drug by Menarini under the brand name Pramistar as a treatment for memory and attention deficits in aging people with neurodegenerative and vascular dementias in Italy and some Eastern European countries.[1][2][3]

It is readily available and sold through online vendors as a dietary supplement in the United States. Dosages range at nearly ten times of that of noopept, making it less potent while offering comparable benefit.

This compound is typically used at dosages of either 400mg thrice daily or 600mg twice daily; both of these dosing regiments totals 1,200mg of pramiracetam a day. It is unclear if pramiracetam should be taken with meals, and it is also unclear if 1,200mg is the optimal dosage or not as this may vary between individuals.

Chemistry

Pramiracetam, or N-[2-(Diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide, is a synthetic compound of the racetam family. Racetams share a pyrrolidine nucleus, a five member nitrogenous ring with a ketone bonded oxygen at R2.[4] This 2-pyrrolidone ring is bound to the terminal carbon of an acetamide group, an ethyl amide chain with a ketone bond (C=O) at the alpha carbon. Pramiracetam features an additional substituion bonded to RN of the acetamide group of a ethyl amide chain with two isopropyl carbon chains attached to the terminal nitrogen. Pramiracetam is structurally analogous to piracetam with an added diisopropyl ethylamino chain.[5] Pramiracetam is prepared from piracetam by substituting the amide group with a dipropan-2-ylaminoethyl group.[4]

Pharmacology

The pharmacological mechanisms of pramiracetam are not well known, but it is thought to be able to enhance high-affinity choline uptake in a manner which is similar to other compounds of the racetam family. As choline is responsible for acetylcholine synthesis, this process essentially allows acetylcholine to accumulate at higher levels than that which it otherwise would. As acetycholine is involved in the function of memory, this could potentially account for its nootropic effects.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

In comparison to the effects of other racetam nootropics such as noopept, this compound can be described as focusing primarily on physical stimulation over that of cognitive stimulation.


Physical effects
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Cognitive effects
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Toxicity and harm potential

The toxicity and long-term health effects of pramiracetam use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because pramiracetam has very little history of human usage. Anecdotal evidence from people who have tried pramiracetam within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

The chronic use of Pramiracetam can be considered as not addictive with a low potential for abuse. It does not seem to be capable of causing psychological dependence among certain users.

Tolerance to many of the effects of Pramiracetam develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Pramiracetam may presents cross-tolerance with all racetam nootropics, meaning that after the consumption of pramiracetam certain nootropics such as noopept and piracetam may have a reduced effect.

Legal issues

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Pramiracetam, being a member of the racetam family, currently is legally available to buy and sell in most countries, but may still vary by region.

  • United Kingdom - Pramiracetam and other racetams are prescription only drugs; however, there is no penalty for possession or importing them.

See also

External links

References