DOB

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Summary sheet: DOB
DOB
DOB.svg
Chemical Nomenclature
Common names DOB, Brolamfetamine, Bromo-DMA
Substitutive name 4-Bromo-2,5-dimethoxyamphetamine
Systematic name 1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane
Class Membership
Psychoactive class Psychedelic
Chemical class Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold Common Heavy
0.2 - 0.2 - 0.75 - 1.75 - 3 mg
Light Strong
Threshold 0.2 mg
Light 0.2 - 0.75 mg
Common 0.75 - 1.75 mg
Strong 1.75 - 3 mg
Heavy 3 mg +
Duration
Total 14 - 24 hours
Onset 2 - 4 hours
Peak 6 - 10 hours
Offset 4 - 8 hours
After effects 4 - 16 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

4-Bromo-2,5-dimethoxyamphetamine (also known as Dimethoxybromoamphetamine, Brolamfetamine, Bromo-DMA, and commonly as DOB) is a psychedelic substance of the amphetamine class that produces unusually long-lived psychedelic effects when administered. It is a member of the DOx family of psychedelic amphetamines.

While DOB had first been synthesized in 1967 and briefly tested in 1971, it took until the 1991 publication of the book PiHKAL ("Phenethylamines I Have Known And Loved") by Alexander Shulgin to be documented in-depth. The entry for it lists the dose range as 1.0 - 3.0 mg with a duration of 18-30 hours, with varying effects reported.[1]

Today, DOB is used as a recreational drug and an entheogen. It is still rarely sold online but is more commonly found in the streets the form of misrepresented LSD due to its ability to fit onto similar-sized blotter paper.[citation needed]

Despite the many decades that have passed since it was first reported, very little data exists about the pharmacological properties, metabolism, and toxicity of DOB in humans. Along with its sensitive dose-response, unusually long and unpredictable duration, many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with using hallucinogens. Therefore it is highly advised to approach this unusually powerful and poorly understood psychedelic substance with the proper amount of precaution and harm reduction practices if choosing to use it.

Chemistry

DOB or 4-Bromo-2,5-dimethoxy-amphetamine is a molecule of the amphetamine class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. DOB contains methoxy functional groups OCH3 attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring. DOB is the amphetamine analogue of the phenethylamine 2C-B.[2]

Pharmacology

Further information: Serotonergic psychedelic

DOB's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. Due to its selectivity, DOB is often used in scientific research when studying the 5-HT2 receptor subfamily. It has been suggested that DOB is a prodrug metabolized in the lungs.[3][4] DOB is an agonist at the Trace-Amine-Associated-Receptor-1 (TAAR1) which contributes to the Amphetamine-Like stimulation.[5]

Site Binding Affinity (nM)
5-HT2A 0.6
5-HT2H 0.44
5-HT2L 59
5-HT2C 69
5-HT1A 3,700
5-HT1B 831
TAAR1 Missing Data

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Visual effects
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Cognitive effects
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Multi-sensory effects
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Transpersonal effects
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Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational DOB use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because DOB is a research chemical with very little history of human usage.

Anecdotal reports from those who have tried DOB suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Overdose

A dangerous overdose on DOB can already start past 3.5 milligrams, although sensitive, inexperienced people can of course overdose at doses lower than these. DOB is suggested to be more toxic than DOI, DOC or DOM[citation needed]. Overdose effects typically include bizzare, delusional and sometimes violent behavior, amnesia, numbness, confusion and anxiety. The person may not be able to communicate and can be severely agitated. The more serious side effects include panic attacks, seizures, dangerously elevated heart rate, blood pressure and vasoconstriction[citation needed], which is reportedly more prominent with DOB than it is with other DOx compounds[citation needed]. Severe vasoconstriction typically develops to its peak several hours into the intoxication and may need medical assistence if blood flow is cut off significantly. If overdose occurs, benzodiazepines should be taken if possible to kill the hyperagitative effects, and a powerful vasodilator may need to be administered via the hospital, to prevent a hypertensive emergency, gangrene or in more serious cases, organ failure and death from the resulting hypoxia. DOB seems to exhibit its toxicity mostly in the brain in the form of memory problems[citation needed] and HPPD as well as on the circulatory system[citation needed]. The LD50 for DOB is unknown.

Tolerance and addiction potential

DOB is not habit-forming, and the desire to use it can decrease with use. It is most often self-regulating.

Tolerance to the effects of DOB is built almost immediately after ingestion. After that, it takes about 4-7 days for the tolerance to be reduced to half and 7-10 days to be back at baseline (in the absence of further consumption). DOB presents cross-tolerance with all psychedelics, meaning that after the consumption of DOB all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe to use on their own, they can become dangerous or even life-threatening when taken with other substances. The list below contains some potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses but still increase the possibility of injury of death. Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

Legality

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • International: DOB is a Schedule I drug under the Convention on Psychotropic Substances.[7]
  • Australia: DOB is listed as Schedule II.[citation needed]
  • Austria: DOB is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).[citation needed]
  • Canada: It is listed as a Schedule 1 as it is an analogue of amphetamine.[8]
  • New Zealand: DOB is Schedule I (Class A) in New Zealand.[citation needed] DOB would also qualify as an analogue under New Zealand's catch-all analogues section in Schedule 3 / Class C of their drug laws which would make 2C-I, 2C-E, DOI, DOB, ephedrine, and pseudoephedrine Schedule 3 compounds in the country.
  • Poland: DOB is controlled in Poland.[9]
  • Switzerland: DOB is illegal in Switzerland.[10]
  • United Kingdom: DOB is Schedule I/Class A in the U.K., making it illegal to sell, buy, or possess without a license.[citation needed]
  • United States: DOB is Schedule I in the U.S., making it illegal to sell, buy, gift, produce or possess without a DEA license.[citation needed]
  • Latvia: DOB is a Schedule I controlled substance.[11]

See also

External links

Discussion

References