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|Summary sheet: 4-FMA|
|Psychoactive class||Stimulant / Entactogen|
|Routes of Administration|
4-Fluoromethamphetamine (abbreviated 4-FMA) is a synthetic substituted amphetamine with stimulant, entactogenic and purported nootropic effects. Many users describe it subjectively as displaying properties and effects somewhere in spectrum between 4-FA and 2-FMA, but with subtle variations in its pharmacodynamics, kinetics and side effect profile that make it less desirable than either.
4-FMA is rarely found on the street and is usually sold as a rare grey area research chemical through online vendors, occasionally along with related designer stimulants such as 2-fluoroamphetamine (2-FA), 3-fluoroamphetamine (3-FA) and 4-fluoroamphetamine (4-FA).. Of these, it is one of the least potent and popular fluorinated designer amphetamine in the series.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Toxicity and harm potential
- 5 Legal issues
- 6 See also
- 7 External links
- 8 References
4-Fluoromethamphetamine (4-FMA) is a synthetic molecule of the substituted amphetamine family. Molecules of this class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. The term "amphetamine" is the contracted form of alpha-methylphenethylamine. 4-fluoromethamphetamine contains a fluorine atom at R4 of its phenyl ring and is therefore a fluorinated analogue of methamphetamine.
Similar to its structural analog 4-FA, 4-Fluoromethamphetamine is thought to act as a releasing agent and reuptake inhibitor of dopamine, serotonin, and norepinephrine, producing stimulating amphetamine-like effects at lower doses and moderate euphoric, entactogenic effects similar to MDMA at dosages above 125mg, albeit much less mild. The mechanism of action of 4-FMA effectively boosts the levels of the norepinephrine, dopamine, and serotonin neurotransmitters in higher doses in the brain by binding to and partially blocking the transporter proteins that normally clear these monoamines from the synaptic cleft. This allows dopamine, norepinephrine, and serotonin to accumulate within various regions of the brain, including its reward pathways, resulting in stimulating, euphoric and entactogenic effects.
In low doses, 4-FMA has been reported to be a moderately functional nootropic for performing tasks or general productivity. At higher dosages, however, it is known to become dysfunctional and recreational due to the scattering quality of its euphoria and stimulation. Unlike its unmethylated analog 4-FA, which presents a distinct entactogenia that feels somewhat similar to MDMA during the initial part of the experience, the subjective effects of 4-FMA are more reminiscent of the effects characteristic of 2-FMA, with its marked dose-ceiling and classical stimulant effects. However, some reports suggest it tends to come with more side effects and bodily strain than other fluorinated amphetamines, explaining its lack of popularity and availability.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
Do not use 4-FMA if you have a history of heart-related issues or experience severe headache after its use. We have been made aware of a report released by Trimbos-instituut and Nationaal Vergiftigingen Informatie Centrum (NVIC), describing incidents of strokes after an increased use of the closely related analogue 4-FA, and there is no reason this does not apply to 4-FMA as well. In addition to the common amphetamine-like effects (agitation, anxiety, tachycardia, hypertension, chest pain et al.), serious cardio- and cerebrovascular complications have been reported, including rhythm (sinus arrhythmia, ventricular extrasystoles (bigeminy), conduction disturbances) and acute cardiac failure. Although a causal relationship has not been confirmed, when presented with a severe headache and lateralization after 4-FA usage, a medical evaluation at an emergency department should be conducted immediately. 
Similar to MDMA, 4-FA and other substances that produce distinct pleasurable tactile "roll"-like sensations, which is typically linked to serotonin-releasing properties, 4-FMA has been reported to be able to produce similar entactogenic effects in addition to traditional stimulant ones.
- Appetite suppression
- Bodily control enhancement
- Physical euphoria - This effect is extremely intense when compared to its physical stimulation.
- Stimulation - The stimulation which 4-FMA presents can be described as being weaker in intensity to amphetamine and less forceful than traditional dopaminergic stimulants such as cocaine.
- Stamina enhancement
- Tactile enhancement - This component, relative to other fluorinated amphetamines like 2-FA or 3-FA, has been reported to be a distinct aspect of the experience.
- Orgasm suppression
Uncomfortable physical side effects
- The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
- Analysis enhancement
- Euphoria - This effect has been reported to occur a series of euphoric waves that recede and reappear randomly throughout the experience. It is distinctly present at dosages above 100mg.
- Empathy, affection, and sociability enhancement - In comparison to other substances, this effect can be described as identical to the effects produced by MDMA, but with less intensity. Like euphoria or Cognitive dysphoria, it is most present at dosages above 200mg.
- Compulsive redosing
- Delusions - As with most potent stimulants, 4-FMA has been reported as having the capacity to produce delusional ideation. However, it is not clear if this occurs in a context unique to the effects of 4-FMA.
- Ego inflation - Some users have reported that this component is distinct, although it is not clear how it compares to other substituted and non-substituted amphetamines.
- Focus enhancement
- Emotion suppression
- Increased libido
- Time distortion - This can be described as the experience of time speeding up and passing much quicker than it usually would when sober.
- Thought acceleration
- Motivation enhancement
- Novelty enhancement
- Paranoia - As with most strong stimulants, 4-FMA has been reported to produce states of paranoia, although it is not clear to which extent this happens relative to other stimulants and under what conditions.
- Stamina enhancement
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational 4-FMA use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4-FMA has very little history of human usage. Anecdotal evidence from people who have tried 4-FMA within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
The LD50 (mouse; i.p.) of 4-FMA is unknown. While 4-FA does not cause long-lasting depletion of brain serotonin unlike MDMA or 4-FA's analogs 4-CA and 4-BA, it is unknown whether this also applies to 4-FMA as well.
It is also worth noting that 4-FMA is particularly caustic in comparison to other compounds and can, therefore, cause chemical burns within the nasal passage and throat if it is insufflated.
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
As with other stimulants, the chronic use of 4-FMA can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of 4-FMA develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). This is how long it takes to reduce the tolerance for the stimulating effects. Tolerance for the entactogenic effects may take a longer period to reduce. 4-FA presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of 4-FMA all stimulants will have a reduced effect.
Abuse of compounds within the amphetamine chemical class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions). A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis. Psychosis very rarely arises from therapeutic use.
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- Stimulants - 4-FMA can be potentially dangerous in combination with other stimulants as it can increase one's heart rate and blood pressure to dangerous levels.
- 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
- Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
- DXM - This combination may cause increased heart rate and panic attacks.
- MXE - Increased heart rate and blood pressure may occur.
- Tramadol - This combination can increase the risk of seizures.
- Cocaine - This combination may increase strain on the heart.
Serotonin syndrome risk
Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels.
- MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants
- Serotonin releasers such as MDMA, 4-FA, MDAI and αMT
- Selective serotonin re-uptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs)
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
- United Kingdom: 4-fluoromethamphetamine is a Class A drug under the Misuse of Drugs Act. 4-FMA is covered by the 1977 addition to the Misuse of Drugs Act of 1971.
- China - As of October 2015 4-FMA is a controlled substance in China.
- Canada: 4-FMA would be considered Schedule I as it is an analogue of Amphetamine.
- New Zealand: 4-FMA is an amphetamine analogue, so is a Schedule 3 controlled substance in New Zealand.
- Responsible use
- Research chemical
- Substituted amphetamines
- 4-fluoromethamphetamine (Bluelight) | http://web.archive.org/web/20141215224213/http://www.bluelight.org/vb/threads/356585-4-fluoromethamphetamine
- The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/17223101
- Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs). (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/15639609
- http://www.sciencedirect.com/science/article/pii/0028390875900994 | Comparison of 4-chloro-, 4-bromo-and 4-fluoroamphetamine in rats: drug levels in brain and effects on brain serotonin metabolism
- http://www.sciencedirect.com/science/article/pii/S0014299906013811 | The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain
- Treatment for amphetamine psychosis | 
- Treatment for amphetamine psychosis | 
- Hofmann FG (1983). A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects (2nd ed.). New York: Oxford University Press. p. 329. ISBN 9780195030570.
- Treatment for amphetamine psychosis | 
- Stimulant Misuse: Strategies to Manage a Growing Problem | http://www.acha.org/prof_dev/ADHD_docs/ADHD_PDprogram_Article2.pdf
- Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28