LSM-775

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Summary sheet: LSM-775
LSM-775
LSM-775.svg
Chemical Nomenclature
Common names LSM-775
Substitutive name Lysergic acid morpholide, N-Morpholinyllysergamide
Systematic name [(8β)-6-Methyl-9,10-didehydroergolin-8-yl](morpholin-4-yl)methanone
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 250 - 500 µg
Light 500 - 750 µg
Common 750 - 1250 µg
Strong 1250 - 1500 µg
Heavy 1500 µg +
Duration
Total 6 - 10 hours
Onset 10 - 30 minutes









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Lysergic acid morpholide (also known as N-Morpholinyllysergamide, and LSM-775) is a novel synthetic research psychedelic of the lysergamide chemical class that produces a generally similar albeit significantly less psychoactive array of LSD-like psychedelic effects when administered. It is a close structural homolog of LSD known mainly for its obscurity, low relative potency, and a few comments that have been made on the "dream-like" sedation it produces as well as potential nausea and other potentially uncomfortable physical effects.

LSM-775 was first investigated in animal models in 1957, where it was observed to be "qualitatively similar to LSD" albeit with a significantly lower potency and "half the duration".[1] It was later briefly described as one of the many analogs of LSD by Alexander Shulgin in his book TiHKAL ("Tryptamines I Have Known and Loved"), in which he mentions conflicting reports, with one stating that "75 micrograms is an effective dose, comparable to a similar dose of LSD, and the other stating that "between 350 and 700 micrograms was needed" while producing "fewer signs of cardiovascular stimulation and peripheral toxicity."[2] Since then, it has been observed that the latter observation is a more accurate description of LSM-775's potency in humans, meaning it possesses about 1/10th the potency of LSD.

Very little data exists about the pharmacological properties, metabolism, and toxicity of LSM-775, and it has very little history of human usage. It has recently appeared on the market alongside research chemical psychedelic lysergamides such as AL-LAD, ETH-LAD and PARGY-LAD as a legal, grey-market alternative to LSD, and commercially distributed through online research chemical vendors (although it is considered to be one of the least popular and available in the series). Despite its low observed potency relative to LSD, it is still highly advised to approach this unstudied hallucinogenic substance with the proper amount of precaution and harm reduction practices if one chooses to use it.

Chemistry

Substitutive structure of a lysergamide.

LSM-775, or lysergic acid morpholide, is a synthetic alkaloid of the lysergamide family. LSM-775 is a structural analog of lysergic acid, with a morpholinyl functional group bound to RN of the chemical structure. This core polycyclic structure is an ergoline derivative, and has overlapping tryptamine and phenethylamine groups embedded within it (although it is principally classed as a tryptamine).

Pharmacology

Further information: Serotonergic psychedelic

LSM-775 likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from LSM-775's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific elucidation.

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Subjective effects

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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects

Cognitive effects

The cognitive effects of LSM-775 can be broken down into several components which progressively intensify proportional to dosage. In comparison to other psychedelics such as psilocybin, AL-LAD and mescaline, LSM-775 is likely able to be described as generally more stimulating and fast-paced in terms of the specific style of thought stream(s) produced and contains a large number of potential effects. However, relative to other lysergamides, it has been noted as being more sedating and "dream-like", in a manner that has drawn comparisons to LSA.

The most prominent of these cognitive effects generally include:

Visual effects

Enhancements

Distortions

Geometry

The visual geometry that is potentially present throughout this trip can be likely described as more similar in appearance to that of MET or 2C-B than psilocin, or DMT. It can be tentatively be described through its variations as primarily intricate in complexity, algorithmic in form, structured in organization, brightly lit, colourful in scheme, synthetic in feel, multicoloured in scheme, flat in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in its corners, immersive in-depth and consistent in intensity. At higher dosages, it may almost consistently result in states of Level 8A or Level 8B visual geometry.[citation needed]

Hallucinatory states

Auditory effects

Multi-sensory effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Transpersonal effects

It should be noted that these effects are the rarest and least reproducible those that can occur during a psychedelic experience. They are considered unique in that that simply taking more of the substance does not necessarily increase the chance they will occur, and are said to rely more on contextual factors such as the user's set and setting rather than the substance or dose itself. Their fullest manifestations are sometimes called "peak", "transcendent" or "transformative" experiences; however, they can still occur on a conceptual or cognitive level that can leave a lasting positive impact on the user.

Combinations

  • Cannabis - When used in conjunction with cannabis, both the visual and cognitive effects of LSM-775 can be intensified and extended with extreme efficiency. This should be used with caution if one is not experienced with psychedelics. Many users sometimes report a dramatically more intense visual trip when combining it with THC concentrates such as hashish as opposed to cannabis flower. However, this can also amplify the anxiety, confusion and psychosis producing aspects of both substances significantly, so extreme caution with this combination is advised.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of LSM-775 have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations and confusion.
  • MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of LSM-775 are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. It is often recommended to wait at least three to four hours after ingesting LSM-775 to take MDMA so as to avoid coming down from the latter while peaking on the former. The synergy between these substances is unpredictable (and likely neurotoxic)[citation needed], and it is best to start with lower dosages than one would take for both substances individually.
  • Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration, nausea, and physical fatigue which can negatively affect a trip if taken in in moderate to dosages. This combination is however reasonably safe in low doses and when used responsibly, this can often take the edge off a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit more stressful on the body.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of a LSM-775 trip. They are very efficient at stopping bad trips at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addiction potential that benzodiazepines possess.
  • Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with lower dosages than one would take for either substance individually.

Toxicity and harm potential

The toxicity and long-term health effects of recreational LSM-775 do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because LSM-775 is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried LSM-775 suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

While no formal studies have been conducted, LSM-775 is likely not habit-forming and it is reasonable to speculate that the desire to use it can actually decrease with repeated administratinon. As with most psychedelics, it likely possesses what is considered an intrinsic, self-regulating aspect to it.

Tolerance to the effects of LSM-775 are built almost immediately after ingestion. After that, it takes about 5-7 days for the tolerance to be reduced to half and 14 days to be back at baseline (in the absence of further consumption). LSM-775 likely presents cross-tolerance with [[Cross-tolerance::all psychedelics], meaning that after the consumption of LSM-775 all psychedelics will have a reduced effect.

Dangerous interactions

Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. Note that the substances listed below refer to LSD specifically; however, there is no reason to believe these negative interactions do not apply equally, if not even more so, to relatively unstudied and structurally similar compounds such as LSM-775 as well.

  • Tramadol - Tramadol has been documented as lowering the seizure threshold[3] and psychedelics may cause occasional seizures.[4][5][6]
  • Stimulants - Stimulants may provoke anxiety, thought loops or psychosis.[7]
  • Lithium - Individuals who take lithium for bipolar disorder or other psychiatric conditions should not take LSM-775. There are numerous anecdotal reports of seizures and or unsafe psychosis from this combination with LSD.[8][9][10][11]

Legality

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See also

External links

Literature

  • Gogerty, J. H., & Dille, J. M. (1957). Pharmacology of d-lysergic acid morpholide (LSM). Journal of Pharmacology and Experimental Therapeutics, 120(3), 340-348. PMID: 13476356

References

  1. Gogerty, J. H., & Dille, J. M. (1957). Pharmacology of d-lysergic acid morpholide (LSM). Journal of Pharmacology and Experimental Therapeutics, 120(3), 340-348. PMID: 13476356
  2. Shulgin, A., & Shulgin, A. (1991). Erowid Online Books: "TIHKAL" - #26. LSD. Retrieved April 14, 2017.
  3. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  4. Tripsit Factsheets - LSD | http://drugs.tripsit.me/lsd
  5. Fisher, D. D., & Ungerleider, J. T. (1967). Grand mal seizures following ingestion of LSD. California Medicine, 106(3), 210. PMCID: PMC1502729
  6. Question ID: 2837 (Ask Erowid) | https://www.erowid.org/ask/ask.php?ID=2837
  7. Tripsit Factsheets - LSD | http://drugs.tripsit.me/lsd
  8. https://erowid.org/chemicals/lsd/lsd_interactions.shtml | LSD Interactions by Erowid
  9. Wanderli. "A Nice Little Trip to the Hospital: An Experience with Lithium & LSD (ID 83935)". Erowid.org. Oct 3, 2010.
  10. MissDja1a. "Having a Seizure and Passing Out: An Experience with Lithium & LSD (ID 75153)". Erowid.org. Dec 16, 2008.
  11. Reddit account of seizure on LSD + Lithium | https://www.reddit.com/r/Psychonaut/comments/17uspp/please_read_a_cautionary_tale_concerning_lsd/