|Molecular structure of 3-FMA|
|Routes of Administration|
|Summary sheet: 3-FMA|
3-Fluoromethamphetamine (also known as 3-FMA) is a novel synthetic ring-substituted fluorinated amphetamine compound that produces entactogenic and stimulant effects when administered. Following the introduction of 3-FEA, 3-FMA subsequently entered the designer drug market as a compound structurally related to a series of fluorinated substituted amphetamines that originally included compounds such as 2-FMA, 3-FA, 4-FMA, 4-FA.
Like its parent compound 3-FA, the pharmacological, toxicological, and subjective effects of 3-FMA in humans have yet to be mapped out in detail. Early reports have so far characterized 3-FMA as a moderately potent serotonin-dominant triple monoamine releaser (or reuptake inhibitor) that produces a relatively short-lived balance of entactogenic and stimulant effects. Based on related compounds, it is not unreasonable to speculate that this compound possesses neurotoxic, cardiotoxic and other potential to-be-discovered toxic properties, which is why extreme caution is advised.
3-FMA has an extremely short history of recreational use and has yet to be documented being sold on the streets. It has recently been made available for sale on the gray market as a research chemical through online vendors. The appearance of it as well as 3-FEA on the research chemicals market coincides with the increased efforts to control the popular entactogenic stimulant 4-FA.
Due to its potent psychostimulant effect, likely habit-forming properties as well as unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.
3-FMA, or 3-fluoromethamphetamine, is a synthetic molecule of the amphetamine family. Molecules of the amphetamine family contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an methyl chain with an additional methyl substitution at Rα (i.e. amphetamines are alpha-methylated phenethylamines). 3-FMA is the 3-position fluorinated analog methamphetamine; however, it is currently speculated to behave more in the manner of shorter-lived entactogenic stimulant. Additionally, is is also a positional isomer of 2-FMA and 4-FMA.
Although 3-FMA has not been formally studied on the same level as traditional amphetamines, it is currently assumed that like other substituted amphetamines with substitutions at similar positions, it most likely acts primarily as a triple releasing agent of serotonin, dopamine, and norepinephrine.
|| This subjective effect breakdown is a stub.|
As such, it may contain incomplete or wrong information and is still in progress.
You can help by expanding it.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death. Early reports suggest 3-FMA has an effect profile that lies in between that of 4-FMA and 2-FMA, possessing both the functional properties of 2-FMA and the euphoric properties of 4-FMA. At lower doses, it has been reported to lean towards functional and productive use, while as one increases the dose, the euphoria becomes both more prevalent as well as distracting.
- Tactile enhancement - This component primarily tends to occur at higher doses only and is rarely observed lower to medium doses.
- Physical euphoria
- Appetite suppression
- Increased heart rate
- Increased perspiration
- Teeth grinding - This component can be considered to be less intense when compared with that of MDMA as well as 2-FMA.
- The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
- Cognitive euphoria
- Thought acceleration
- Focus enhancement
- Anxiety suppression
- Analysis enhancement
- Motivation enhancement
- Compulsive redosing
- Increased music appreciation - This component primarily tends to happen at higher doses only, as low to medium doses of 3-FMA are more focused and productivity-oriented.
- Time distortion - This can be described as the experience of time speeding up and passing much quicker than it usually would when sober.
Anecdotal reports which describe the effects of this compound within our experience index include:
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As such, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
The toxicity and long-term health effects of human recreational 3-FMA use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 3-FMA has an extremely short history of human usage, becoming available only in mid-2017. Anecdotal evidence from people who have tried 3-FMA within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
Due to its putative serotonin-releasing and entactogenic properties, it is possible that 3-FMA may display excess activity at the 5-HT2b receptor, which, would make it cardiotoxic with long-term use as seen in other 5-HT2b agonists such as fenfluramine and MDMA.
It is perhaps worth noting that in the field of medicinal chemistry, the fluorine substitution is sometimes seen as desirable in central nervous system pharmaceutical agents, and is a common practice due to the corresponding increase in lipophilicity granted by the substitute.
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
Although it still remains to be seen, the chronic use of 3-FMA likely can be considered moderately addictive with a high potential for abuse and capable of causing psychological dependence among a certain population of users. When dependence or addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of 3-FMA develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 10 days to be back at baseline (in the absence of further consumption). 3-FMA presents cross-tolerance with all dopaminergic and serotonergic stimulants and entactogens, meaning that after the consumption of 3-FMA all stimulants will have a reduced effect (including atypical stimulants one might not expect, like MDMA or amphetamine due to its reliance on dopamine and norepinephrine to exert its full euphoric effect).
Abuse of compounds within the amphetamine chemical class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions). A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis. Psychosis very rarely arises from therapeutic use.
Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.
- Stimulants - 3-FMA can be potentially dangerous in combination with other stimulants as it can increase one's heart rate and blood pressure to dangerous levels.
- 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
- Alcohol - It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
- DXM - This combination may cause increased heart rate and panic attacks.
- MXE - Increased heart rate and blood pressure may occur.
- Tramadol - This combination can increase the risk of seizures.
- MDMA - The neurotoxic effects of MDMA may be increased when combined with amphetamines.
- Cocaine - This combination may increase strain on the heart to dangerous levels.
This legality section is a stub.
As such, it may contain incomplete or wrong information. You can help by expanding it.
3-FMA is currently a grey area compound within all parts of the world, meaning its regulation lies in a legal grey area and that it is not known to be specifically illegal ("scheduled") within any country. However, people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.
- United States: 3-FMA may be considered an analogue of amphetamine under the Federal Analogue Act. The Federal Analogue Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug (in Schedule I or II) to be treated as if it were also in Schedule I or II, but only if it is intended for human consumption.
- United Kingdom: 3-FMA is considered a Class A drug as a result of the amphetamine analog clause of the Misuse of Drugs Act 1971.
- Canada: 3-FMA would be considered Schedule I as it is an analogue of Amphetamine.
- China - As of October 2015 3-FMA is a controlled substance in China.
- New Zealand: 3-FMA is an amphetamine analogue, so is a Schedule 3 controlled substance in New Zealand.
- Quednow, B., Girreser, U., Junge, T., & Ro, P. (2005). Isomeric Fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs), 148, 143–156. https://doi.org/10.1016/j.forsciint.2004.05.003
- Fluorine substituent effects (on bioactivity) | http://www.sciencedirect.com/science/article/pii/S002211390100375X
- Treatment for amphetamine psychosis | 
- Treatment for amphetamine psychosis | 
- Hofmann FG (1983). A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects (2nd ed.). New York: Oxford University Press. p. 329. ISBN 9780195030570.
- Treatment for amphetamine psychosis | 
- Stimulant Misuse: Strategies to Manage a Growing Problem | http://www.acha.org/prof_dev/ADHD_docs/ADHD_PDprogram_Article2.pdf
- Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
- Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I
- Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
- 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | http://www.sfda.gov.cn/WS01/CL0056/130753.html