PMA

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PMA can cause serious side effects even at moderate doses, such as hyperthermia and serotonin syndrome, which can easily result in death or hospitalization.

As a result, it is strongly discouraged to use this substance. Please see this section for more details.

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It may potentially contain incorrect information, particularly regarding that of dosage, duration, subjective effects, toxicity and other risks.

PMA
Molecular structure of PMA
PMA.svg
Chemical Nomenclature
Common names PMA, 4-MA, Death
Substitutive name para-Methoxyamphetamine
Systematic name 1-(4-methoxyphenyl)propan-2-amine
Class Membership
Psychoactive class Entactogen
Chemical class Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold ?
"?" is not a number.
mg
Light 20 - 40 mg
Common 40 - 60 mg
Strong Higher dosages can result in serious hyperthermia and eventually death.
Duration
Total short









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: PMA

PMA (para-Methoxyamphetamine, also known as 4-MA or death) is a highly toxic and dangerous drug of the amphetamine class. It has been around since the 1970s, where it was sold along with PMMA as Ecstasy, and has gained great attention as a number of hospitalizations and deaths were reported from ingesting this substance. It usually does not produce much noticeable effects, which leads people ingesting more or combining it with other substances, until they eventually overdose. It produces dangerous adverse effects, including a sudden and extremely high rise in body temperature and blood pressure, abnormal heartbeats, dehydration and sometimes severe dizziness.

PMA, along with other drugs like PMMA and PMEA have very little recreational value and are considered as one of the most dangerous and toxic substances known. It is strongly recommended that these two drugs should be completely avoided.

Chemistry

PMA (para-Methoxyamphetamine or 4-MA) is a molecule of the amphetamine class. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. It contains a methoxy (OCH3) functional group bound to the R4 carbon of the phenyl ring. It is the 4-Methoxy analog of amphetamine.

Pharmacology

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PMA acts as a selective serotonin releasing agent (SSRA) with weak effects on dopamine and norepinephrine transporters. However, relative to MDMA, it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake inhibitor in comparison. It evokes robust hyperthermia while producing only modest hyperactivity and serotonergic neurotoxicity, substantially lower than that caused by MDMA. Anecdotal reports suggest it is not particularly euphoric at all, perhaps even dysphoric in contrast. PMA has also been shown to act as a potent, reversible inhibitor of the enzyme MAO-A with no significant effects on MAO-B, and the combination of this property and serotonin release is likely responsible for its high lethality potential.

It appears that PMA elevates body temperatures dramatically; the cause of this property is suspected to be related to its ability to inhibit MAO-A and at the same time releasing large amounts of serotonin, effectively causing serotonin syndrome. It appears that PMA activates the hypothalamus much more strongly than MDMA and other drugs like ephedrine, thereby causing rapid increases in body temperature (which is the major cause of death in PMA mortalities).[1]

Subjective effects

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This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects

Cognitive effects

Visual effects

At moderate to high dosages, PMA is capable of producing typically mild or moderate visual distortions, which are usually more common and pronounced than with MDMA, but significantly less when compared with most psychedelics, such as 2C-B or LSD.

Suppressions

Distortions

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
We also recommend that you practice diligent independent research and the most thorough harm reduction practices when using this substance.

PMA and its relative PMMA can be considered extremely toxic when compared to other substances such as Methamphetamine or MDMA. Ingestion of PMA has been associated with severe tachycardia (abnormally high heart rate), seizures, dehydration, hyperthermia, and death. PMA has a relatively slow onset, causing many users to redose which causes excess toxicity.

It is strongly recommended that one use harm reduction practices when using this drug.

Legal issues

  • Canada: PMA is a Schedule I substance.
  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[2]
  • United States: PMA is a Schedule I substance.
  • United Kingdom: PMA is a Class A drug.
  • Switzerland: PMA is illegal in Switzerland.[3]

See also

References

  1. https://en.wikipedia.org/wiki/Para-Methoxyamphetamine
  2. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  3. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html