2C-T-2

From PsychonautWiki
Jump to: navigation, search
Summary sheet: 2C-T-2
2C-T-2
2C-T-2.svg
Chemical Nomenclature
Common names 2C-T-2, Rosy
Substitutive name 4-Ethylthio-2,5-dimethoxyphenethylamine
Systematic name 2-[4-(Ethylthio)-2,5-dimethoxyphenyl]ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold Common Heavy
3 - 5 - 10 - 20 - 30 mg
Light Strong
Threshold 3 - 5 mg
Light 5 - 10 mg
Common 10 - 20 mg
Strong 20 - 30 mg
Heavy 25 - 30 mg +
Duration
Total 6 - 10 hours
Onset 30 - 60 minutes
Peak 2.5 - 5 hours
Offset 2 - 4 hours
After effects 2 - 6 hours



Insufflated
Dosage
Threshold Common Heavy
1 - 5 - 10 - 20 - 25 mg
Light Strong
Threshold 1 - 5 mg
Light 5 - 10 mg
Common 10 - 20 mg
Strong 20 - 25 mg
Heavy 25+ mg
Duration
Total 3 - 7 hours
Onset 5 - 15 minutes
Peak 2 - 4 hours
Offset 1 - 2 hours
After effects 2 - 4 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

2,5-Dimethoxy-4-ethylthiophenethylamine (also known as 2C-T-2, and Rosy) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.

2C-T-2 was first synthesized and tested for activity in humans by Alexander Shulgin in 1981[1] and described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[2] It is a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.[3]

Following the initial positive results found by Shulgin's research group, a more formal study was carried out by psychedelic psychotherapy pioneer Myron J. Stolaroff who was interested in evaluating the potential use of 2C-T-2 in psychotherapy.[4] Based on the experiences of forty participants in the study who took 2C-T-2, Stolaroff compared the effects favorably to MDMA, describing it as more emotionally opening and permitting a wider exploration of feelings and thoughts.

Anecdotal reports generally characterize 2C-T-2 as a highly dose sensitive psychedelic known for its open headspace and unpredictable body load.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has little history of human usage. Many reports also indicate that its physical effects may be too severe for those who are not already experienced with psychedelics or suffer from pre-existing physical conditions. It is highly advised to approach this hallucinogenic substance with the proper amount of precaution and harm reduction practices if choosing to use it.

History and culture

History icon.svg

This History and Culture section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Chemistry

Generic structure of a phenethylamine molecule

2C-T-2, or 2,5-dimethoxy-4-ethylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-T-2 belongs to the 2C family of phenethylamines which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T-2 is also substituted at R4 with an ethyl thioether group.

2C-T-2 is a close structural analogue of 2C-T-7; the two differ by the length of the alkane chain in their thioether functional group.[5]

Pharmacology

Further information: Serotonergic psychedelic

The mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.

Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (such as 2C-T-7, 4-MTA, and the 2,5-desmethoxy derivative of 2C-T-7) are known to act as selective monoamine oxidase A inhibitors. Therefore, this substance may likewise have MAOI effects.[6]

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
Child.svg

Visual effects
Eye.svg

Cognitive effects
User.svg


Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational 2C-T-2 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.

Anecdotal reports suggest that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

2C-T-2 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T-2 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-2 presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T-2 all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

If 2C-T-2 does have MAOI effects as has been speculated,[citation needed] this could indicate that 2C-T-2 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[7] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

Legality

  • United Kingdom - 2C-T-2 is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[8]
  • United States: 2C-T-2 is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.
  • Australia: 2C-T-2 is illegal in Australia as of 2005.
  • Austria: 2C-T-2 is illegal to possess, produce and sell under the SMG. (Suchtmittelgesetz Österreich)
  • Belgium: 2C-T-2 was added to the list of illegal psychotropic substances on Nov 8, 2004.
  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[9]
  • Denmark: 2C-T-2 was added to category B of the controlled substances list on August 23, 2003.[10]
  • European Union: EU Council published an order on Dec 6, 2003, asking all member states to control 2C-I, 2C-T-2, 2C-T-7, and TMA-2.
  • Germany - Possession, production and sale is illegal.[11]
  • Italy: 2C-T-2 was added to the "Tabella 1" in a Jan 11, 2005 Ministry of Health statement.
  • Japan: 2C-T-2 is controlled as a "Designated Substance" (Shitei-Yakubutsu) by the Pharmaceutical Affairs Law, making it illegal to possess or sell
  • Latvia: 2C-T-2 is a Schedule I controlled substance.[12]
  • Netherlands: It was classified as an unregistered pharmaceutical as of April 12, 1999. Unlicensed manufacture, sale, import, trade and possession of this substance can be prosecuted.
  • Switzerland: Possession, production and sale is illegal.[13]
  • China - As of October 2015 2C-T-2 is a controlled substance in China.[14]
  • Canada: 2C-T-2 would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[15]

See also

External links

References

  1. Shulgin, Alexander. "Pharmacology Lab Notes #4". Lafayette, CA. (1981-1982). p474 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_pharmacology_notebook4_searchable.pdf
  2. Shulgin, A., & Shulgin, A. (1991). IsomerDesign: "PiHKAL" - #33 - 2C-I. Retrieved Jan 22, 2018.
  3. Shulgin, A., & Shulgin, A. (1991). Erowid Online Books: "PIHKAL" - The Chemical Story. Retrieved April 14, 2017.
  4. Stolaroff, MJ; Wells, C. Preliminary results with new psychoactive agents 2C-T-2 and 2C-T-7. In Jahrbuch für Ethnomedizin und Bewußtseinsforschung (Yearbook of Ethnomedicine and the Study of Consciousness); Rätsch, C; Baker, J, Eds., 1993; Vol. 2, pp 99–117. (MAPS.org) | http://www.maps.org/images/pdf/1993_stolaroff_1.pdf
  5. http://isomerdesign.com/PiHKAL/read.php?id=40
  6. http://www.sciencedirect.com/science/article/pii/S0006295206005971
  7. Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
  8. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made
  9. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  10. https://www.riigiteataja.ee/aktilisa/1090/2201/1004/109022011004Lisa1.pdf
  11. BtMG Anlage I | https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html
  12. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  13. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  14. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
  15. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28