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Changa (or xanga) is a blanket term for a smokable blend that contains the psychedelic substance dimethyltryptamine (DMT) infused onto a MAOI containing herb such as syrian rue or banisteriopsis caapi.
Changa is usually made by pouring a DMT solution (such as DMT that has been mixed with isopropyl alcohol) over a chosen blend of herbs and letting the solvent evaporate. The final product can then be smoked in a manner like tobacco or cannabis. Although there are many varieties of changa, like ayahuasca, the key active ingredients are DMT and an MAOI. The inclusion of the MAOI is reported to extend the experience by 10 to 30 minutes while making it more subjectively coherent and less chaotic than freebase DMT.
An alternate way experience changa is to orally dose a MAOI agent (either pharmaceutical or herbal) and then proceed to vaporize DMT as one normally would after the MAOI has taken effect. This has the advantage of allowing the user to "break through" on significantly lower dose.
The percentages of DMT and MAOI concentration in the mixture can vary. A typical mixture would be characterized by breakthrough experiences at a dosage of approximately "one full bong bowl" (with each breath held in for at least 20 full seconds). There have also been reports of breakthroughs occurring with changa that has been rolled into joints, though this is a far less reliable method of doing do.
A guide to properly preparing changa can be accessed here.
"Enhanced leaf" is a related term that is sometimes used to describe DMT-containing herb-mixtures that do not contain MAOIs. Common herbs that can be used for this purpose can range from passionflower to mint leaves.
Toxicity and harm potential
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Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when taken with other substances. The following lists some known dangerous combinations, but cannot be guaranteed to include all of them. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.
- Stimulants - The neurotoxic effects of drugs like MDMA may be increased when combined with a changa mixture.
- 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
- DXM - This combination may cause increased heart rate and panic attacks.
- MXE - Increased heart rate and blood pressure may occur.
- Tramadol - This combination can increase the risk of seizures.
Serotonin syndrome risk
Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.
- MAOIs such as syrian rue, banisteriopsis caapi, 2C-T-7, αMT, phenelzine, selegiline, and moclobemide
- Serotonin releasers such as MDMA, 4-FA, methamphetamine, methylone and αMT
- Selective serotonin re-uptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs) such as tramadol and DXM
There is an increased risk of serotonin syndrome when changa (or more specifically, the MAOI component of it) is taken with many antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
- Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210