1P-ETH-LAD

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Summary sheet: 1P-ETH-LAD
1P-ETH-LAD
1P-ETH-LAD.svg
Chemical Nomenclature
Common names 1P-ETH-LAD
Substitutive name 1-propionyl-6-ethyl-6-nor-lysergic acid diethyamide
Systematic name (6aR,9R)-4-propionyl-N,N-diethyl-7-ethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide[1]
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 25 - 30 µg
Light 30 - 60 µg
Common 60 - 100 µg
Strong 100 - 200 µg
Heavy 200 µg +
Duration
Total 6 - 12 hours
Onset 30 - 90 minutes
Peak 2 - 4 hours
Offset 2 - 4 hours
After effects 6 - 24 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

1-Propionyl-6-ethyl-6-nor-lysergic acid diethyamide (also known as 1P-ETH-LAD) is a semisynthetic psychedelic substance of the lysergamide chemical class. It is a designer drug analog and suspected prodrug to ETH-LAD, which shares a close structural relationship with LSD and 1P-LSD. Anecdotal reports suggest that this compound produces largely similar psychedelic effects comparable to ETH-LAD or AL-LAD.

Like its parent compound ETH-LAD, this compound has been reported to be moderately to significantly more potent than LSD itself. It has also been reported as being subtly different in effect to LSD and is often described as being more visual and synaesthetic, with a deeper, less emotionally-charged headspace analogous to that of psychedelics like 2C-E or DPT. It has also been reported to be more likely to induce undesirable effects like anxiety, thought loops in addition to pronounced nausea and other discomforting physical effects it displays relative to other lysergamides.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-ETH-LAD, and it has little history of human usage before January 2016.[2] It has recently become commonly marketed alongside other designer psychedelics such as 1P-LSD and ETH-LAD as a legal alternative to LSD and is commercially distributed through online research chemical vendors.

Chemistry

Generic structure of a lysergamide

1P-ETH-LAD, or 1-propionyl-6-ethyl-6-nor-lysergic acid diethylamide, is a semi-synthetic alkaloid of the lysergamide family. 1P-ETH-LAD is a structural analog of lysergic acid, with an N, N-diethylamide functional group bound to RN of the chemical structure. This core polycyclic structure is an ergoline derivative and has tryptamine and phenethylamine groups embedded within it.

1P-ETH-LAD's structure contains a bicyclic hexahydro indole fused to a bicyclic quinoline group (nor-lysergic acid). 1P-ETH-LAD does not contain a methyl group substituted at R6 of its nor-lysergic acid skeleton; the nor- prefix represents this. Instead, 1P-ETH-LAD is substituted at R6 with an ethyl group and at R1 with a propionyl group. At carbon 8 of the quinoline, an N, N-diethyl carboxamide is bound.

1P-ETH-LAD is a chiral compound with two stereocenters at R5 and R8. 1P-ETH-LAD, also called (+)-D-1P-ETH-LAD, has an absolute configuration of (5R, 8R). The three other stereoisomers of 1P-ETH-LAD have not been shown to possess psychoactive properties.[3]

Pharmacology

Further information: Serotonergic psychedelic

This compound likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 1P-ETH-LAD's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

1P-ETH-LAD shares many common traits with its parent compound LSD; it appears to be roughly equal in potency as well as similar in mechanism although the progression and duration of effects are compressed (while remaining qualitatively less intense and more manageable) due to suspected differences in how it is metabolized. Research has shown formation of ETH-LAD from 1P-ETH-LAD incubated in human serum, suggesting that it functions as a pro-drug.[4]

Subjective effects

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In comparison to other psychedelics such as psilocybin mushrooms, LSA and ayahuasca, 1P-ETH-LAD is significantly more stimulating and fast-paced in its cognitive effects and general head space. In comparison to LSD, it is reported to be less anxiety-provoking and more emotionally comfortable and forgiving.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Visual effects
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Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational 1P-ETH-LAD use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 1P-ETH-LAD is a research chemical with very little history of human usage.

Anecdotal reports from those who have tried 1P-ETH-LAD suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed).

Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

1P-ETH-LAD is not habit-forming and the desire to use it can actually decrease with use. Like with most psychedelics, it is thought to be most often self-regulating rather than self-reinforcing.

Tolerance to the effects of 1P-ETH-LAD are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). It should be noted that this only applies to the physiological tolerance. Mental or psychological tolerance is thought by some to take two weeks or more for the full experience to re-manifest.

Due to its activity at the 5-HT2A receptor, 1P-ETH-LAD presents cross-tolerance with all psychedelics, meaning that after the consumption of 1P-ETH-LAD all psychedelics (particularly the tryptamines and other lysergamides) will display a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe to use on their own, they can become dangerous or even life-threatening when taken with other substances. The list below contains some potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses but still increase the possibility of injury of death. Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

  • Tramadol - Tramadol lowers seizure threshold[5] and psychedelics may cause occasional seizures.[6][7][8]
  • Stimulants - Stimulants may provoke anxiety or thought loops.[9]
  • Lithium - Due to its similiarity to LSD, individuals who take lithium for bipolar disorder or other psychiatric conditions should not take ETH-LAD. There are numerous anecdotal reports of seizures and or psychosis from the LSD-lithium combination.[10][11][12][13]

Legal status

It is unclear in many countries whether this compound is legal or not and one should take precaution by assuming it is illegal to avoid legal issues.

  • United States: 1P-ETH-LAD may be considered illegal in the U.S. under the Federal Analogue Act.
  • United Kingdom: It is illegal to produce, supply, or import this substance under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[14]

See also

External links

References

  1. https://wiki.dmt-nexus.me/1P-ETH-LAD
  2. "1P-ETH-LAD" - Google Trends. (n.d.). | https://trends.google.com/trends/explore?q=%221P-ETH-LAD%22
  3. Nichols, D. E. (2018). Chemistry and structure–activity relationships of psychedelics. Behavioral Neurobiology of Psychedelic Drugs, 1-43.
  4. Brandt, S. D., Kavanagh, P. V., Westphal, F., Elliott, S. P., Wallach, J., Stratford, A., Nichols, D. E., and Halberstadt, A. L. (2017) Return of the lysergamides. Part III: Analytical characterization of N6-ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD). Drug Test. Analysis, doi: 10.1002/dta.2196. (Wiley Online Libary | http://onlinelibrary.wiley.com/doi/10.1002/dta.2196/abstract
  5. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  6. Tripsit Factsheets - LSD | http://drugs.tripsit.me/lsd
  7. Fisher, D. D., & Ungerleider, J. T. (1967). Grand mal seizures following ingestion of LSD. California Medicine, 106(3), 210. PMCID: PMC1502729
  8. Question ID: 2837 (Ask Erowid) | https://www.erowid.org/ask/ask.php?ID=2837
  9. Tripsit Factsheets - LSD | http://drugs.tripsit.me/lsd
  10. https://erowid.org/chemicals/lsd/lsd_interactions.shtml | LSD Interactions by Erowid
  11. Wanderli. "A Nice Little Trip to the Hospital: An Experience with Lithium & LSD (ID 83935)". Erowid.org. Oct 3, 2010.
  12. MissDja1a. "Having a Seizure and Passing Out: An Experience with Lithium & LSD (ID 75153)". Erowid.org. Dec 16, 2008.
  13. Reddit account of seizure on LSD + Lithium | https://www.reddit.com/r/Psychonaut/comments/17uspp/please_read_a_cautionary_tale_concerning_lsd/
  14. Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted