3-MMC

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Summary sheet: 3-MMC
3-MMC
3-MMC.svg
Chemical Nomenclature
Common names 3-MMC, Metaphedrone
Substitutive name 3-Methylmethcathinone
Systematic name (RS)-2-​(Methylamino)-​1-​(3-​methylphenyl)-​1-​propanone
Class Membership
Psychoactive class Stimulant / Entactogen
Chemical class Cathinone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 25 mg
Light 25 - 75 mg
Common 75 - 150 mg
Strong 150 - 300 mg
Heavy 300 mg +
Duration
Total 4 - 6 hours
Onset 10 - 30 minutes
Come up 30 - 60 minutes
Peak 2 - 3 hours
Offset 1 - 1.5 hours
After effects 2 - 4 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

3-Methylmethcathinone (also known as 3-MMC or metaphedrone[1]) is a novel stimulant-entactogen substance of the cathinone class that produces a mixture of classical stimulant and entactogenic effects when administered. It is a member of a group known as the substituted cathinones, all of which are derivatives of cathinone, the principal active component in the khat plant (Cathulla edullis) of eastern Africa.

As with many of its research chemical cathinone predecessors, 3-MMC is known to come in the form of either a white powder or crystallized shards which users can ingest to produce a powerful, fast-acting but short-lived euphoric stimulant-entactogen effects, particularly when they are insufflated, vaporized or injected.[citation needed]

It has gained notoriety for its associated tendency to induce compulsive redosing and addictive behaviors in a seemingly significant percentage of its users as well the ability to readily induce paranoid, anxiety, various delusional states and stimulant psychosis when taken too frequently, in excessive amounts, or over extended periods of time.[citation needed]

Very little data exists about the pharmacological properties, metabolism, and toxicity of 3-MMC, and it has little history of human usage. 3-MMC first became available on the online research chemical market, shortly after the banning of mephedrone. It is a prominent example of a contemporary designer drug specifically chosen to mimic and/or replace the functional and structural features of its recently-controlled predecessors.[citation needed]

Chemistry

3-MMC, or 3-Methylmethcathinone, is a molecule of the substituted cathinone class. Cathinones are a sub-category of amphetamines, sharing share the core amphetamine structure of a phenyl ring bound to an amino (NH2) group through an ethyl chain and an additional methyl substitution at Rα.

3-MMC and other cathinones are differentiated by their ketone substitution on the beta carbon of the amphetamine skeleton, meaning they are β-keto-amphetamines. 3-MMC has two methyl substitutions on its cathinone skeleton, one at R3 of the phenyl ring, and a second at the nitrogen group RN.

3-MMC is analogous to mephedrone; it is identical in structure except for the placement of the methyl group at R3 instead of R4.

Pharmacology

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely speculation based upon its structure and subjective effect similarities to other stimulants such as mephedrone, amphetamine and 2-FMA. 3-MMC most likely acts as both a dopamine and norepinephrine releasing agent. This means it may effectively boost the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.[citation needed]

Subjective effects

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This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Cognitive effects
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Visual effects
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After effects
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Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

As with most research chemicals, the long-term effects of 3-MMC have not been researched extensively enough to provide accurate information of its risks and harm.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

As with other stimulants, the chronic use of 3-MMC can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. It is said that this compound is considerably more addictive than that of mephedrone.

Tolerance to many of the effects of 3-MMC develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 3-MMC presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of 3-MMC all stimulants will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe to use on their own, they can become dangerous or even life-threatening when taken with other substances. The list below contains some potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses but still increase the possibility of injury of death. Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

  • 25x-NBOMe/25x-NBOH - Members of the 25x family are highly stimulating and physically straining. Combinations with stimulants should be avoided due to the risk of excessive stimulation. This can result in panic attacks, thought loops, seizures, increased blood pressure, vasoconstriction, and heart failure in extreme cases.
  • Alcohol - Alcohol can be dangerous to combine with stimulants due to the risk of accidental over-intoxication. Stimulants mask the sedative effects of alcohol, which is the main factor people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects of alcohol are left unopposed, which can result in blackouts and respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
  • DXM - Combinations with DXM should be strictly avoided due to DXM's effects on serotonin and dopamine reuptake. This can lead to panic attacks, hypertensive crisis, or serotonin syndrome.
  • MXE - Combinations with MXE may dangerously elevate blood pressure and increase the risk of psychosis.
  • Tramadol - Tramadol lowers the seizure threshold.[3] Combinations with stimulants may further increase this risk.
  • MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
  • Cocaine - This combination may increase strain on the heart.

Serotonin syndrome risk

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

Legal status

  • Austria: 3-MMC is illegal to possess, produce and sell under the NPSG. (Neue-Psychoaktive-Substanzen-Gesetz Österreich)[citation needed]
  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[5]
  • China - Since October 2015, the drug has been banned (along with an enormous amount of other chemicals) in China. Due to this ban, many chemicals have become increasingly difficult to attain since the manufacturing was mainly done by Chinese chemical companies.[6]
  • Czech Republic - 3-MMC is banned in the Czech Republic.[7]
  • United Kingdom - 3-MMC is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.[8]
  • Germany - On December 13th, 2014, 3-MMC was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.[9]

See also

External links

Forums

References

  1. Adamowicz, P., Gieron, J., Gil, D., Lechowicz, W., Skulska, A., & Tokarczyk, B. (2016). 3-Methylmethcathinone—Interpretation of blood concentrations based on analysis of 95 cases. Journal of analytical toxicology, 40(4), 272-276. https://doi.org/10.1093/jat/bkw018
  2. Urban Dictionary page on "gurning" http://www.urbandictionary.com/define.php?term=gurning
  3. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. https://doi.org/10.1007/BF03161089
  4. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  5. http://portal.anvisa.gov.br/documents/33868/3233596/55+-+RDC+N%C2%BA+143-2017-DOU.pdf/de80dc69-acb4-48b3-a6ac-1198993b0c1e
  6. 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | http://www.sfda.gov.cn/WS01/CL0056/130753.html
  7. http://www.mzcr.cz/Admin/_upload/files/3/Nov%C3%A9%20PL.pdf
  8. United Kingdom. (2010). Misuse of Drugs Act 1971 (S.I. 2010/1207). London: The Stationery Office Limited. Retrieved February 9, 2018, from https://www.legislation.gov.uk/uksi/2010/1207/made
  9. Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften (28. BtMÄndV)| http://www.buzer.de/gesetz/11392/a189949.htm