TMA-2

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TMA-2
Molecular structure of TMA-2
TMA-2.svg
Chemical Nomenclature
Common names TMA-2
Substitutive name 2,4,5-trimethoxyamphetamine
Systematic name 1-(2,4,5-trimethoxyphenyl)propan-2-amine
Class Membership
Psychoactive class Psychedelic, Stimulant
Chemical class Psychedelic Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 5 - 10 mg
Light 10 - 20 mg
Common 20 - 40 mg
Strong 40 - 60 mg
Heavy 60 mg +
Duration
Total 8 - 12 hours
Onset 20 - 120 minutes
Come up 1.5 - 3 hours
Peak 4 - 6 hours
Offset 2 - 4 hours
After effects 4 - 24 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: TMA-2

2,4,5-Trimethoxyamphetamine (abbreviated TMA-2) is a synthetic psychedelic amphetamine and the amphetamine homologue of TMPEA-2 known to produce a unique spectrum of hallucinogenic and stimulant effects that differ substantially from other psychoactive phenethylamines. TMA-2 along with TMA-6 and others are members of the trimethoxylated family of phenethylamines. Members in this family been observed to produce a complex mixture of hallucinogenic, stimulant, psychedelic and entactogenic effects that qualitatively separates it from other psychedelic phenethylamine compounds like members of the 2C-x or DOx series.

TMA-2 was first synthesized by Viktor Bruckner in 1933[1], but was not investigated as a psychoactive chemical until Alexander Shulgin synthesized and tested it in 1962[2]. Shulgin published his synthesis and initial research findings in a 1964 paper, describing the effects as similar to mescaline, though lacking in color effects, producing less nausea and prone to causing anxiety and restlessness.[3].

There are occasional references to the use of TMA-2 in early 1970's counter-culture publications[4][5], describing the drug as being rarely produced for sale and expensive in comparison to LSD. This suggests that there was only very limited human usage of TMA-2 between its invention and the publication of its synthesis and pharmacology in Shulgin's 1991 book PiHKAL ("Phenethylamines I Have Known And Loved"). Since then it has been regarded as an oddball and a novelty in the psychedelics community and is only occasionally sought after intentionally. In terms of its subjective effects, it is known for its lack of classic psychedelic visuals compared to its parent compound (mescaline) and is known instead for its instead a unique stimulating body-high and altered headspace that ranges from euphoric to dysphoric variably.

Anecdotal reports suggest that TMA-2 is a highly unpredictable and dose-sensitive substance that can produce uncomfortable amounts of body load, nausea, overstimulation, and inconsistencies between experiences.

In modern times, TMA-2 is used as an obscure recreational drug and a occasional entheogen. It is rarely sold on the streets and is almost exclusively obtainable as a grey area research chemical through the use of online vendors.

Chemistry

TMA-2, or 2,4,5-trimethoxyamphetamine, is a molecule of the substituted amphetamine class. Amphetamines are substituted phenethylamines, being comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. TMA-2 contains methoxy functional groups CH3O- attached to carbons R2 and R4 and R5 of the amphetamine backbone.[6]

Pharmacology

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This pharmacology section is incomplete.

You can help by adding to it.

Further information: Serotonergic psychedelic

TMA-2's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

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This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

You can help by expanding it.

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects

  • Spontaneous physical sensations - The "body high" of TMA-2 is manifested as somewhat intense in comparison to most classical psychedelics such as LSD. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin, but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Stimulation - In terms of its effects on the physical energy levels of the tripper, TMA-2 is usually considered to be extremely stimulating at levels which do not become overwhelming, resulting in a shakiness and unsteadiness of the hands but encouraging one to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
  • Tactile enhancement - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most TMA-2 trips.
  • Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
  • Vasoconstriction - This effect is usually only present at higher dosages, but can be particularly uncomfortable.
  • Bodily control enhancement
  • Pupil dilation
  • Increased blood pressure

Cognitive effects

The cognitive effects of TMA-2 are described as powerful mental stimulation along with undertones of intoxication that can increase the connectivity and rate of conceptual thinking without being overwhelming.

The total sum of these cognitive components regardless of the setting generally includes:

Visual effects

Enhancements

Distortions

Auditory effects

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational TMA-2 use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because TMA-2 has very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried TMA-2 suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

TMA-2 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of TMA-2 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). TMA-2 presents cross-tolerance with all psychedelics, meaning that after the consumption of TMA-2 all psychedelics will have a reduced effect.

Legal issues

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Switzerland: TMA-2 is a controlled substance in Switzerland.[7]

See also

External links

References

  1. Bruckner, V. (1933), Über das Pseudonitrosit des Asarons. J. Prakt. Chem., 138: 268–274. doi:10.1002/prac.19331380907 | http://onlinelibrary.wiley.com/doi/10.1002/prac.19331380907/abstract
  2. Shulgin, Alexander. "Pharmacology Lab Notes #1". Lafayette, CA. (1960-1976). p54 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook1_searchable.pdf
  3. Shulgin, A.T. Experientia (1964) 20: 366. doi:10.1007/BF02147960 | https://erowid.org/archive/rhodium/chemistry/shulgin.meo-34-dialkoxyamphetamines.html
  4. 'Acidman'. "Straight Dope". Berkeley Tribe, December 18-25, 1970 p23 (Independent Voices) | http://voices.revealdigital.com/cgi-bin/independentvoices?a=d&d=BFBJFGJ19701218.1.23
  5. Lampe, Matt. "Dope-O-Scope". Ann Arbor Sun, November 12-25, 1971, p16 (Independent Voices) | http://voices.revealdigital.com/cgi-bin/independentvoices?a=d&d=BFBJFGJ19701218.1.23
  6. https://www.erowid.org/library/books_online/pihkal/pihkal162.shtml
  7. https://www.admin.ch/opc/de/classified-compilation/20101220/index.html