2M2B

Death may result when GABAergic substances are combined with other depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or alcohol.

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Summary sheet: 2M2B

2M2B
Chemical Nomenclature
Common names	2M2B, 2m2b, 2-methyl-2-butanol
Substitutive name	2-methyl-2-butanol
Systematic name	2-methylbutan-2-ol
Class Membership
Psychoactive class	Depressant
Chemical class	Alcohol
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 0.5 mL Light 1 - 5 mL Common 5 - 10 mL Strong 10 - 15 mL Heavy 15 mL +There have been unconsciousness and deaths reported at as low as 18 mL respective 29 mL. Duration Total 8 - 14 hours Onset 10 - 50 minutes Peak 6 - 8 hours Offset 4 - 6 hours After effects 4 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

2-Methyl-2-butanol (also known as tert-amyl alcohol or 2M2B) is a tertiary alcohol substance that produces depressant, hypnotic, and anxiolytic effects. Historically, it has been used in anesthesia as a component of avertin fluid mixed with tribromoethanol and water. It has a strong solvent smell reminiscent of gasoline, but with little flavor. 2M2B's simple structure and intoxicating effects have led to its use as a recreational drug.

Fusel alcohols including 2M2B are a grain fermentation by-product and therefore present in many alcoholic beverages. Trace levels of 2M2B have also been detected in various food substances, including fried bacon and cassava, rooibos tea, and fruits (such as apple and pineapple).

Chemistry

2-methyl-2-butanol is also known as tert-amyl-alcohol, 2M2B, or amylene hydrate. 2-methyl-2-butanol is an alcohol with the formula C₅H₁₁OH. 2-methyl-2-butanol is comprised of butane, an alkyl chain of four carbons. This chain is substituted at R₂ with a methyl group CH₃- and an alcohol group OH-. It is synthesized by the reaction of 2-methyl-2-butene with water in the presence of an acid catalyst.

Pharmacology

2-Methyl-2-butanol inhibits binding to a proconvulsant site on the GABA receptor which causes negatively charged chloride ions to enter neurons and increase the amount of excitation necessary to cause the neurons to fire. As it is a tertiary alcohol, it cannot be metabolized by alcohol dehydrogenase into aldehydes (which cause the hangover associated with consuming large amounts of ethanol). This makes 2M2B significantly safer than primary alcohols. However, a consequence of this is that 2-methyl-2-butanol has an extended duration of action with effects which last up to 12 hours after its consumption.

Subjective effects

In comparison to other depressants of a similar nature, 2M2B is comparatively closer to alcohol than GHB in terms of its subjective effects and is also considerably more sedating than alcohol but less sedating than GHB.

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects

• • Sedation - In comparison to alcohol, 2-methyl-2-butanol is significantly more sedating. On low to moderate doses, one may feel a lack of energy, resulting in extreme difficulty in performing basic tasks. This effect can last up to 24 hours afterwards.
  • Muscle relaxation
  • Motor control loss
  • Appetite enhancement
  • Dizziness
  • Pain relief
  • Respiratory depression

Cognitive effects

• • Analysis suppression
  • Anxiety suppression
  • Cognitive euphoria
  • Compulsive redosing
  • Delusions of sobriety - This is the false belief that one is perfectly sober despite obvious evidence to the contrary such as severe cognitive impairment and an inability to fully communicate with others.
  • Disinhibition
  • Focus suppression
  • Language suppression
  • Memory suppression
    • Amnesia
  • Thought deceleration

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 2-methyl-2-butanol

Toxicity and harm potential

The toxicity and long-term health effects of recreational 2M2B use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown although the lowest recorded fatal dose in a human is 30mL. However, 2M2B is expected to be less toxic than ethanol as it cannot be metabolized into aldehydes in the same way. Anecdotal evidence from people who have tried 2M2B within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

As with any other GABA receptor agonist, repeated use and increasing tolerance will eventually result in a withdrawal syndrome upon abrupt discontinuation resembling alcohol, barbiturate, or benzodiazepine withdrawal, up to and including delirium tremens ("the shakes"). The chronic use of this compound can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 2M2B develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). 2M2B presents cross-tolerance with all GABAgenic depressants, meaning that after the consumption of 2M2B all depressantss will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

• Depressants (1,4-Butanediol, 2M2B, alcohol, benzodiazepines, barbiturates, GHB/GBL, methaqualone, opioids) - This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration. There is also an increased risk of suffocating on one's vomit while unconscious. If nausea or vomiting occurs before a loss of consciousness, users should attempt to fall asleep in the recovery position or have a friend move them into it.

• Stimulants - It can be dangerous to combine depressants with stimulants due to the risk of accidental excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states. This combination can also potentially result in severe dehydration if one's fluid intake is not closely monitored. If choosing to combine these substances, one should strictly limit themselves to a pre-set schedule of dosing only a certain amount per hour until a maximum threshold has been reached.

• Dissociatives - This combination can unpredictably potentiate the amnesia, sedation, motor control loss and delusions that can be caused by each other. It may also result in a sudden loss of consciousness accompanied by a dangerous degree of respiratory depression. If nausea or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the recovery position or have a friend move them into it.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

• Germany: 2M2B is a prescription medicine, according to Anlage 1 AMVV ("Amylenhydrat").
• United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.

See also

• Responsible use
• Depressant
• Alcohol
• GHB
• GBL

External links

• 2-methyl-2-butanol (Wikipedia)