PMMA

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PMMA can cause serious side effects even at moderate doses, such as hyperthermia and serotonin syndrome, which can easily result in death or hospitalization.

As a result, it is strongly discouraged to use this substance. Please see this section for more details.

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It may potentially contain incorrect information, particularly regarding that of dosage, duration, subjective effects, toxicity and other risks.

PMMA
Molecular structure of PMMA
PMMA.svg
Chemical Nomenclature
Common names PMA, 4-MMA
Substitutive name para-Methoxymethamphetamine
Systematic name 1-(4-Methoxyphenyl)-N-methylpropan-2-amine
Class Membership
Psychoactive class Entactogen
Chemical class Amphetamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Common 100 - 120 mg?
Strong Higher dosages can result in serious hyperthermia and eventually death.
Duration
Total short









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Summary sheet: PMMA

para-Methoxymethamphetamine (also known as 4-MMA and commonly as PMMA) is a highly dangerous and toxic synthetic substance of the amphetamine class that is closely related to PMA. Like PMA, it is known for producing extremely dangerous, life-threatening side effects. At lower dosages, its effects are somewhat different from PMA, with reduced tendency to cause severe hyperthermia while producing more entactogenic effects that can be mistaken for MDMA (although at higher dosages it does have the same risk as PMA). Its history of use is unknown, but it has appeared more frequently in the 2000s and 2010s. It is generally less potent than PMA.

PMMA, along with other drugs like PMA and PMEA have very little recreational value and are considered as one of the most dangerous and toxic substances known. It is strongly recommended that these two substancesshould be completely avoided.

Chemistry

PMMA (para-Methoxymethamphetamine or 4-MMA) is a molecule of the substituted amphetamine class. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at Rα. It contains a methoxy (OCH3) functional group bound to the R4 carbon of the phenyl ring, as well as a methyl substitution at RN. PMMA is the N-methylated version of PMA and the 4-Methoxy analog of Methamphetamine.

Pharmacology

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PMMA, like PMA most likely acts as a selective serotonin releasing agent (SSRA) with weak effects on dopamine and norepinephrine transporters. However, relative to MDMA, it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake inhibitor in comparison. It evokes robust hyperthermia while producing only modest hyperactivity and serotonergic neurotoxicity, substantially lower than that caused by MDMA. Anecdotal reports suggest it is not particularly euphoric at all, perhaps even dysphoric in contrast. PMMA has also been shown to act as a potent, reversible inhibitor of the enzyme MAO-A with no significant effects on MAO-B, and the combination of this property and serotonin release is likely responsible for its high lethality potential. It is likely metabolized to PMA, just like methamphetamine is metabolized to amphetamine in the body.

It appears that PMMA elevates body temperatures dramatically; the cause of this property is suspected to be related to its ability to inhibit MAO-A and at the same time releasing large amounts of serotonin, effectively causing serotonin syndrome. It appears that PMMA activates the hypothalamus much more strongly than MDMA and other drugs like ephedrine, thereby causing rapid increases in body temperature (which is the major cause of death in PMMA mortalities).[citation needed]

Subjective effects

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This subjective effect breakdown is a stub.

As such, it may contain incomplete or wrong information and is still in progress.

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The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.


Physical effects
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Cognitive effects
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Visual effects
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Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding upon or correcting it.
We also recommend that you practice diligent independent research and the most thorough harm reduction practices when using this substance.

PMMA and its relative PMA can be considered extremely toxic when compared to other substances such as Methamphetamine or MDMA. Ingestion of PMMA has been associated with severe tachycardia (abnormally high heart rate), seizures, dehydration, hyperthermia, and death. PMMA has a relatively slow onset, causing many users to redose which causes excess toxicity.

It is strongly recommended that one use harm reduction practices if choosing to use this substance.

Legality

  • Canada: PMMA is a Schedule I substance.
  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[1]
  • Germany: PMMA is an Anlage I controlled substance.
  • United States: PMMA is unscheduled, but can be considered an analog of PMA under the Federal Analog Act.
  • United Kingdom: PMMA is a Class A drug.
  • Switzerland: PMMA is illegal in Switzerland.[2]

See also

References

  1. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  2. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html