MCPP

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Summary sheet: MCPP
MCPP
MCPP.svg
Chemical Nomenclature
Common names mCPP
Substitutive name meta-Chlorophenylpiperazine
Systematic name 1-(3-chlorophenyl)piperazine
Class Membership
Psychoactive class Stimulant
Chemical class Piperazine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 15 - 20 mg
Light 20 - 50 mg
Common 50 - 120 mg
Strong 120 - 150 mg
Heavy 150 mg +
Duration
Onset 20 - 60 minutes
Peak 2 - 4 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

meta-Chlorophenylpiperazine (also known as mCPP) is a stimulant drug of the phenylpiperazine class. It was first synthesized as one in a series of potential novel antihistamines by Thomas H. Wicker Jr. in 1951 as part of his doctoral work at the University of Florida. [1] Unlike many other stimulants like amphetamine, mCPP is generally considered to be unpleasant. mCPP is notable for inducing anxiety[2], and causing migraines and severe headaches.[3] mCPP is occasionally encountered as an adulterant in street MDMA.[4]

Chemistry

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mCPP is a drug in the phenylpiperazine class. On the meta-position of the phenyl group, there is a chlorine atom.

Pharmacology

mCPP acts as an agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3 and 5-HT7 receptors, as well as inhibiting the serotonin transporter.[5]. Substances that act at the 5-HT2B receptor, most notably fenfluramine, can cause significant heart problems which can be fatal in some individuals.[6] mCPP's action at the 5-HT2A receptor may explain its psychedelic-like effects.

mCPP is an active metabolite of the antidepressant trazodone.[7]

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. These effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Cognitive effects
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Visual effects
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Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

mCPP is not known to be addictive, but there are not any studies exclusively on its addiction potential.

Dangerous interactions

mCPP is metabolized by cytochrome P450 2D6[8], and concurrently taking inhibitors of that enzyme results in increased serum levels of mCPP. Commonly encounter inhibitors of CYP2D6 include ciprofloxacin, bupropion (Wellbutrin), fluoxetine (Prozac) and grapefruit juice.[9]

Although many psychoactive substances are safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The following lists some known dangerous combinations, but may not include all of them. A combination that appears to be safe in low doses can still increase the risk of injury or death. Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume.

  • 25x-NBOMe & 25x-NBOH - Members of the 25x family are highly stimulating and physically straining. Combinations with stimulants should be avoided due to the risk of excessive stimulation. This can result in panic attacks, thought loops, seizures, increased blood pressure, vasoconstriction, and heart failure in extreme cases.
  • Alcohol - Alcohol can be dangerous to combine with stimulants due to the risk of accidental over-intoxication. Stimulants mask the sedative effects of alcohol, which is the main factor people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects of alcohol are left unopposed, which can result in blackouts and respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
  • DXM - Combinations with DXM should be strictly avoided due to DXM's effects on serotonin and dopamine reuptake. This can lead to panic attacks, hypertensive crisis, or serotonin syndrome.
  • MXE - Combinations with MXE may dangerously elevate blood pressure and increase the risk of psychosis.
  • Tramadol - Tramadol lowers the seizure threshold.[10] Combinations with stimulants may further increase this risk.
  • MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.[11]
  • Cocaine - This combination may increase strain on the heart.

Serotonin syndrome risk

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

Legal issues

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As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Austria: Since January 1, 2012, mCPP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
  • United Kingdom - mCPP is a Class C, Schedule 4 (Part 1) drug in the United Kingdom.[13]
  • United States - mCPP is unscheduled in the United States, but could be considered an analogue of benzylpiperazine if it is sold for human consumption.
  • Switzerland - mCPP is illegal in Switzerland.[14]
  • China - As of October 2015 mCPP is a controlled substance in China.[15]

See also

External links

References

  1. Wicker, Thomas H. (1951) Derivatives of Piperazine. XII. Synethesis of 1-Arylpiperazines and Amino Acid Derivatives. Retrieved from University of Florida Theses & Dissertations Collection. alphbibnum: 000554269 | http://ufdc.ufl.edu/UF00091637/00001
  2. Anxiogenic-like effects of mCPP and TFMPP in animal models are opposed by 5-HT1C receptor antagonists. | https://www.ncbi.nlm.nih.gov/pubmed/2767117
  3. The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study. | https://www.ncbi.nlm.nih.gov/pubmed/10891925
  4. mCPP: an undesired addition to the ecstasy market | http://journals.sagepub.com/doi/pdf/10.1177/0269881109102541
  5. The effects of administration of mCPP on psychological, cognitive, cardiovascular, hormonal and MHPG measurements in human volunteers. | https://www.ncbi.nlm.nih.gov/pubmed/7814826
  6. Drugs and Valvular Heart Disease | http://www.nejm.org/doi/full/10.1056/NEJMp068265
  7. 1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole | http://onlinelibrary.wiley.com/doi/10.1111/j.2042-7158.1982.tb04701.x/abstract;jsessionid=9006CB66248FC2F30E99D5AEAB847661.f04t01
  8. Human CYP2D6 and metabolism of m-chlorophenylpiperazine | http://www.biologicalpsychiatryjournal.com/article/S0006-3223(97)00483-6/abstract
  9. P450 Drug Interaction Table | http://medicine.iupui.edu/CLINPHARM/ddis/main-table
  10. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. https://doi.org/10.1007/BF03161089
  11. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  12. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
  13. Home Office Controlled Drugs | https://www.gov.uk/government/publications/controlled-drugs-list--2/list-of-most-commonly-encountered-drugs-currently-controlled-under-the-misuse-of-drugs-legislation
  14. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  15. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.