Project talk:Methcathinone

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Summary sheet: Methcathinone
Methcathinone
Methcathinone.svg
Chemical Nomenclature
Common names Methcathinone, Ephedrone, Methcat, Cat, Jeff, MC
Substitutive name α-methylamino-propiophenone
Systematic name (RS)-2-(methylamino)-1-phenyl-propan-1-one
Class Membership
Psychoactive class Stimulant / Entactogen
Chemical class Cathinone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



⇣ Oral
Dosage
Threshold 25 mg
Light 50 - 100 mg
Common 100 - 200 mg
Strong 200 - 300 mg
Heavy 300 mg +
Duration
Total 4 - 6 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions


Methcathinone (also known as Ephedrone originally, Methcat and CAT) is a synthetic stimulant substance of the cathinone chemical class. It produces standard amphetamine-like stimulant effects. It is similar to the cathinone compounds found in the khat plant of eastern Africa and mephedrone in its structure and effects.

Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known mephedrone or synthesized from OTC drugs containing ephedrine or pseudoephedrine.

Chemistry

Methcathinone is comprised of a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain containing a beta-ketone group (what is known as a cathinone molecule) with an additional methyl substitution at Rα. It can be thought of as the cathinone homolog of methamphetamine as it has the same general formula, differing only in the addition of a single double bonded oxygen.

Pharmacology

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Although the effects of methcathinone have not been formally studied on the same level as amphetamines, it is possible to speculate that like other simple substituted cathinone, it most likely acts primarily as a dopamine and norepinephrine reuptake inhibitor.[1] The result of this is an effective increase in the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally clear those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the key area of the brain linked to reward and pleasure to extra-endogenous levels, resulting in stimulating, motivatory and euphoric effects.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
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    • Stimulation - Methcathinone is reported to be extremely stimulating and energetic. The style of stimulation can be described as "forced". This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily body shakes and vibrations become present.
    • Physical euphoria - Physical euphoria is very prominent when used responsibly (i.e. reasonable dosing and spacing between experiences) and can lead to profound feelings of social and physical disinhibition.
    • Dehydration - The Dehydration that is experienced during a methcathinone experience is generally more severe than with other stimulants like Amphetamine. Due to this, you must take extreme care and hydrate yourself constantly, so that you do not suffer from Rhabdomyolysis. This is done generally by observing your body, if there is any pain, if your kidneys feel weird, and if your urine is yellow to green-yellow like tea. Read the wiki and inform yourself on rhabdomyolysis since it is a very bad thing to have, you could die from it if it is severe enough and untreated over long time. Generally you can mitigate it by seeing if your urine is yellow, then if it is, and you do not urinate regularly drink a glass of water every 15 or 30 minutes (as long as you don't drink too much and hurt yourself) and your urine should become clear. As Long as you keep hydrating yourself your kidneys will be normal and functioning and you will be good, keep drinking water constantly after it becomes clear, for some few more hours but a bit less amount wise so that you don't have the problem again.
    • Increased heart rate - The increase in heart rate is generally weaker than with other stimulants like Methamphetamine.
    • Increased perspiration - The amount of perspiration is very high. You will sweat extremely easily in hot places and if you do any physical activity. Mixing Methcathinone with DXM will make you drip drops of sweat literally all the time. Hydrate yourself due to this increased perspiration or you will lose a large amount of water very fast.
    • Increased blood pressure -
    • Muscle contractions - These sudden muscle contractions are experienced during the comedown. This is due to the deficiency of Dopamine in the brain, which replicates symptoms to Parkinson's disease. These tremors are temporary and will subside within a few hours.
    • Muscle spasms - Typically occurs during the Comedown. This is due to depletion of Dopamine in the brain.
    • Spontaneous physical sensations - The "body high" of Methcathinone can be characterized as a moderate to extreme euphoric sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. -
    • Stomach cramps -
    • Tactile enhancement
    • Teeth grinding - This effect when experienced alongside euphoria can often lead to users mildly or intensely clenching their jaw muscles, sometimes even to the point where the individual’s facial expression begins to change. This is sometimes colloquially called “gurning”[4] and is typically only experienced in common to high dosages.
    • Vasoconstriction -

Cognitive effects
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After effects
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Toxicity and harm potencial

Neuro toxicity

Illicit methcathinone manufactured using potassium permanganate oxidation of ephedrine or pseudoephedrine has been connected with neurotoxicity caused by manganese poisoning.[2]

Dependence and abuse potential

Methcathinone, due to its highly addictive nature, can often cause extreme compulsive redosing.

It is strongly recommended that one use harm reduction practices when using this substance.

Legal status

Internationally, methcathinone is a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances.[3]

  • Australia: Methcathinone is a Schedule 9 controlled substance.[4]

See also


Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:



External links

References

  1. ↑ Cathinone derivatives: A review of their chemistry, pharmacology and toxicology | DOI 10.1002/dta.31
  2. ↑ https://www.nejm.org/doi/full/10.1056/NEJMoa072488
  3. ↑ https://www.incb.org/incb/en/psychotropics/green-list.html
  4. ↑ "POISONS STANDARD DECEMBER 2019". Office of Parliamentary Counsel. Retrieved December 19, 2019. 
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