Prolintane

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Summary sheet: Prolintane
Prolintane
Molecular structure of Prolintane
Prolintane.svg
Chemical Nomenclature
Common names Prolintane
Substitutive name Phenylpyrrolidinopentane
Systematic name 1-Phenyl-2-pyrrolidinylpentane
Class Membership
Psychoactive class Stimulant
Chemical class Pyrrolidine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 5 - 15 mg
Light 15 - 25 mg
Common 25 - 45 mg
Strong 45 - 60 mg
Heavy 60 mg +
Duration
Total 4 - 6 hours
Onset 20 - 60 minutes
Come up 20 - 40 minutes
Peak 2 - 3 hours
Offset 1 - 2 hours
After effects 2 - 6 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

1-Phenyl-2-pyrrolidinylpentane (also known as Prolintane or Pyrrolidinopentiophenone, and by the trade names Catovit, Promotil, and Villescon) is a synthetic central nervous system (CNS) stimulant that is structurally similar to the substituted pyrrolidine class of compounds such as MDPV and A-PVP albeit with notably attenuated effects. Prolintane was first synthesized in the 1950s, where it was found primarily to act as as a norepinephrine-dopamine reuptake inhibitor (NDRI)[1] which is thought to confer it stimulant and potential nootropic qualities.

Historical reports show records of the preparation of prolintane for use as a mild CNS stimulant, wakefulness agent, and cessation aid for cocaine addiction. It has been marketed in Europe since the 1960s as an antidepressant (i.e. due to its anti-fatigue properties) and analeptic. It has a history of being used in neuropsychiatric research related to CNS stimulants with reduced side effects. Therapeutic uses of prolintane in Africa, Europe, and Australia include the treatment of narcolepsy, ADHD, fatigue, and orthostatic hypotension. It is not approved for pharmaceutical use in the United States.[2]

The first reports of prolintane abuse appeared in Europe during the early 2000s when prolintane was identified in tablets distributed at a rave party. Later reports documented the recreational use of prolintane in the United States, where it appears to substitute for recreational amphetamine and other stimulant use.[3]

Chemistry

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Prolintane, or 1-Phenyl-2-pyrrolidinylpentane, is a synthetic stimulant of the pyrrolidine class.

Pharmacology

Prolintane is thought to act primarily as a mild norepinephrine-dopamine reuptake inhibitor.[4] Reduced re-uptake of norepinephrine and dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this reduced reuptake activity is an enhanced and prolonged concentration and resulting post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neurons. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high that prolintane can induce at higher doses.

Because it acts principally as a catecholaminergic re-uptake inhibitor, prolintane could be considered more like cocaine or methylphenidate than amphetamine in its pharmacological mechanism of action [5] In contrast, amphetamine acts primarily as an agonist to release dopamine and noradrenaline indirectly via activation of the TAAR1 receptor.[citation needed]

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

Cognitive effects

The general cognitive effects of prolintane can be described as being similar to those of classical CNS stimulants with attenuated activity. At common dosages, the prolintane high is described as being subtle and functional, comparable to a proportionally smaller dose of dextroamphetamine with a smoother, less jittery come up and a milder comedown. Higher doses of prolintane, however, can likely intensify numerous negative effects such as anxiety and disorganized thoughts; at extremely high doses or continued use, delusions and psychosis become likely.

After effects

The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Toxicity and harm potential

The toxicity and long-term health effects of recreational prolintane use do not seem to have been studied in any scientific context, and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried prolintane within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

Lethal dosage

The exact lethal dosage of prolintane is unknown, and no formal studies have been carried out in humans. The typical adult therapeutic dose of prolintane has been 10-40mg daily. In therapeutic trials, 20mg prolintant is a mild stimulant equivalent to 100mg caffeine. In a study of fatigued volunteers the administration of 20mg or 40mg prolintane produced similar, but less intense effects than 20mg d-amphetamine. In experimental studies of healthy volunteers, prolintane has little cardiovascular activity following the single dose of 20mg.[6]

Tolerance and addiction potential

Unlike some of the other more potent stimulants in its class, the chronic use of prolintane can be considered mildly to moderately addictive with only a moderate potential for abuse and is capable of causing psychological dependence among certain users.

When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a potential risk among users of prolintane as it can cause compulsive redosing, although typically to a far lesser degree than the notoriously compulsive cathinone analogs A-PVP and MDPV.

Psychosis

Main article: Stimulant psychosis

User reports indicate that chronic abuse or single overdose exposure of prolintane can potentially lead to psychosis. Psychotic symptoms from prolintane can include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, grandiosity, paranoid delusions, confusion, increased aggression, and irritability.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legal issues

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See also

External links

References

  1. GB Patent 807835
  2. Barceloux, D. G. (2012). Medical toxicology of drug abuse: synthesized chemicals and psychoactive plants (pp. 69-70). Wiley.
  3. Barceloux, D. G. (2012). Medical toxicology of drug abuse: synthesized chemicals and psychoactive plants (pp. 69-70). Wiley.
  4. GB Patent 807835
  5. http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1
  6. Barceloux, D. G. (2012). Medical toxicology of drug abuse: synthesized chemicals and psychoactive plants (pp. 69-70). Wiley.
  7. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210