Benzydamine

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Summary sheet: Benzydamine
Benzydamine
Benzydamine.svg
Chemical Nomenclature
Common names Benzydamine, Tantum Verde
Substitutive name Benzydamine
Systematic name 3-(1-Benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine
Class Membership
Psychoactive class Deliriant
Chemical class Indazole alkaloid
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 0.5 g
Light 0.5 - 1 g
Common 1 - 1.5 g
Strong 1.5 - 2 g
Heavy 2 g +
Duration
Total 5 - 8 hours
Onset 20 - 60 minutes
Peak 3 - 6 hours
Offset 3 - 8 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Benzydamine (also known as Difflam or Tantum Verde) is a topical anaesthetic of the indazole alkaloid chemical class. It is sometimes found in small doses in over-the-counter products used to treat sore throats. In Germany and Poland, it is sold as a vaginal douching agent under the brand name Tantum Rosa. This product is also easily accessible across the world through the use of online stores such as eBay.

Alternatively, benzydamine can be used as a powerful psychoactive hallucinogen for recreational purposes. In high doses, it acts as a unique deliriant and CNS stimulant.[1] Such use, particularly among teenagers, has been reported in Poland,[1] Brazil[2][3] and Romania.

Chemistry

Benzydamine, or 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine, is a synthetic benzyl-indazole molecule. Benzydamine contains a benzene and pyrazole ring fused to form a bicyclic indazole group. A benzyl substituent C6H5CH2- is bound to R1 of the indazole ring. This indazole ring is also substituted at R3 with an ether chain consisting of the oxygen group bonded to a propyl amine chain. The terminal amine RN of this structure is substituted with two methyl groups (dimethyl). Benzydamine is produced as a hydrochloride salt.

Pharmacology

Benzydamine is a locally acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase and is not ulcerogenic.

In terms of the pharmacology behind its hallucinogenic effects, this aspect of benzydamine remains unstudied and is subject to much speculation.

Subjective effects

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Toxicity and harm potential

The vaginal douching agents such as Tantum Rosa and other products consistently contain large amounts of salt which, if consumed, can cause serious kidney damage.

The toxicity and long-term health effects of recreational benzydamine use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because benzydamine is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried benzydamine suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Extraction

Benzydamine is usually extracted from Tantum Rosa douching agents which are available online. In order to consume the substance safely, one must first remove the dangerous levels of salt contained within the sachet. This can be done by dissolving the substance in a small amount of water (25ml/sachet). After the substance has mostly dissolved after stirring (warm or just boiled water works best as the salt will dissolve more easily), wait 10 minutes. After 10 minutes has past the benzydamine should have formed a layer on the top and the salt have settled at the bottom. The benzydamine should be filtered out using filter paper but do not pour the salt that may settle at the bottom as this will simply add back most of the salt you have tried to remove. It is best to consume the remaining paste by stirring it into very strong squash and drinking it.

Legal issues

Benzydamine is legal and available in over-the-counter preparations in most parts of the world.

See also

External links

References

  1. 1.0 1.1 Recreational abuse with benzydamine hydrochloride (tantum rosa) (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/17364645
  2. Recreational use of benzydamine as a hallucinogen among street youth in Brazil (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/19784487
  3. Use abusive of benzydamine in Brazil: an overview in pharmacovigilance (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/19784487