|Summary sheet: 2C-H|
|Common names||2C-H, DMPEA|
|Psychoactive class||Stimulant / Psychedelic|
|Routes of Administration|
2,5-Dimethoxyphenethylamine (also known as 2C-H and DMPEA) is a lesser-known psychoactive substance of the phenethylamine class that belongs to the 2C-x family of substituted phenethylamines. Lacking significant psychedelic effects, it is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.
2C-H was first synthesized in 1932 by Johannes S. Buck and its effects in humans were explored in the 1970s by Alexander Shulgin, who published his findings in the book PiHKAL (Phenethylamines I Have Known and Loved).
In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken sublingually. It is theorized to be orally active if taken in combination with a MAOI. However, it is unknown whether this would result in typical 2C-x psychedelic effects.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. It is highly advised to use harm reduction practices when using this substance.
2C-H, or 2,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-H contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a hydrogen atom attached to carbon R4 of the phenyl ring. 2C-H belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring, and is also their simplest member. It is commonly used as a precursor to other compounds of the 2C family, including 2C-B, 2C-C, 2C-I, and 2C-N.
There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. However, it has been shown to have binding affinity towards 5-HT2C and 5-HT2A receptors in rats.
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There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
The toxicity and long-term health effects of recreational 2C-H use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-H has almost no documented history of human usage.
Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
- Canada: As of October 31st, 2016, 2C-H is a controlled substance (Schedule III) in Canada, and is thus illegal to possess, produce and sell.
- United States: As of July 9, 2012, 2C-H is a Schedule I controlled substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.
- United Kingdom - 2C-H is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
- Buck, J. S. (1932). HYDROXY-AND DIHYDROXYPHENYLETHYLMETHYLAMINES AND THEIR ETHERS. Journal of the American Chemical Society, 54(9), 3661-3665. https://doi.org/10.1021/ja01348a024.
- So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334
- Shulgin, Alexander; Ann Shulgin (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.
- 2C-H BioAssay Results (PubChem) | https://pubchem.ncbi.nlm.nih.gov/compound/76632#section=BioAssay-Results
- United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made