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Antihistamines are pharmaceutical drugs that inhibits the action of histamine by either blocking its attachment to histamine receptors or inhibiting the enzymatic activity of histidine decarboxylase which catalyzes the transformation of histidine into histamine. Anti-histamines are commonly used for the relief of allergies and sometimes for their psychoactive effects.
Most antihistamines have inverse agonistic effects upon histamine receptors.
Antihistamines are seen throughout organic chemistry including psychoactive and anti-allergenic compounds.
- Emanuel, M. B. (1999). Histamine and the antiallergic antihistamines: a history of their discoveries. Clinical & Experimental Allergy, 29(S3), 1-11. https://doi.org/10.1046/j.1365-2222.1999.00004.x-i1
- Sicherer, Scott H. M.D., Understanding and Managing Your Child's Food Allergy. Baltimore: The Johns Hopkins University Press, 2006 ISBN 0-8018-8492-6.