Serotonergic psychedelics (also known as serotonergic hallucinogens) are a class of hallucinogenic substances with a method of action strongly tied to modifying the normal neurotransmission of serotonin in the central nervous system (CNS).
Serotonin, which is also referred to as 5-HT (from its chemical name 5-hydroxy-tryptamine) is a naturally-occurring monoamine neurotransmitter which is tied to developmental, cardiovascular, gastrointestinal, and endocrine function, sensory perception, behaviors such as aggression, appetite, sex, sleep, mood, cognition, and memory, many of which have yet to be fully understood.
Proposed method of action
While the method of action of serotonergic psychedelics is not fully understood, serotonergic psychedelics are known to show affinities for various 5-HT receptors in different ways and levels, and may be classified by their activity at different 5-HT sub-sites, such as 5-HT1A, 5-HT1B, 5-HT2A, etc.
Many serotonergic psychedelics, such as the family of tryptamines, have very strong structural similarities to serotonin itself, which partially explains the affinity for certain 5-HT sites. It is almost unanimously agreed that most serotonergic psychedelics produce their effect by acting as strong partial agonists at the 5-HT2A receptors.
The cortico-striato-thalamo-cortical loops (also known as CSTC-loops) seem to be central to the function of psychedelics, which are also regulated by the serotonergic system. These control loops connect brain areas like the frontal lobe, the striatum and the thalamus; they aggregate, process and forward internal and external information.
The disruption of the neurotransmitter balance causes these control loops to collapse overwhelmed, leading to the flooding of the frontal lobe with neuronal excitatory glutamate; internal and external stimuli as well as all kinds of non-conscious contents can freely move up to the cerebral cortex and appear as visions in consciousness. Furthermore, there is an over-activation of the locus coerlueus and thereby widespread norepinephrine secretion, causing a state of spiritual transcendence and sometimes even intense spiritual experiences.
Worth noting is that selective serotonin reuptake inhibitors (a class of antidepressants including Paxil, Prozac, and Zoloft) can increase the dosage required for hallucinogenic effects of serotonergic psychedelics in some people based on anecdotal reports. Some users, however, have found this to be entirely untrue for them, so users who are using daily antidepressants should, at first, only attempt a common dosage.
- 4-PO-DMT (Psilocybin)
- 4-HO-DMT (Psilocin)
- 4-HO-MET (Metocin)
- 4-HO-DET (Ethocin)
- 4-HO-MiPT (Miprocin)
- 4-HO-DiPT (Iprocin)
- 4-AcO-DMT (Psilacetin)
- 4-AcO-MET (Metacetin, Azomet)
- 4-AcO-DET (Ethacetin)
- 4-AcO-MiPT (Mipracetin)
- 4-AcO-DiPT (Ipracetin)
- 5-HO-DMT (Bufotenin)
- 5-MeO-MiPT (Moxy)
- 5-MeO-DiPT (Foxy)
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- Edelrausch im Labor – Neuro Culture Lab (German)