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Nausea can be described as a sensation of unease and discomfort in the upper stomach with an involuntary urge to vomit.[1][2][3] It often, but not always, precedes vomiting. This effect usually occurs at the onset of the experience and dissipates as the peak takes its toll.

In the context of substance usage, nausea and vomiting can occur as a result of stomach irritation through the consumption of materials which it is not used to digesting. These materials can include things such as chemical powders or plant matter. Alternatively, nausea may occur as a direct pharmacological result of how the particular substance affects the brain. If this is the case, the nausea is therefore inseparable from the experience itself and will likely occur to varying extents regardless of the route of administration.

Nausea is often accompanied by other coinciding effects such as stomach bloating, stomach cramps, and dizziness. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, deliriants, dissociatives, and stimulants.

Psychoactive substances

Compounds within our psychoactive substance index which may cause this effect include:

Experience reports

Anecdotal reports which describe this effect within our experience index include:

See also

External links


  1. Tanaka, E., Kamata, T., Katagi, M., Tsuchihashi, H., & Honda, K. (2006). A fatal poisoning with 5-methoxy-N, N-diisopropyltryptamine, Foxy. Forensic science international, 163(1-2), 152-154.
  2. Shulgin, A. T., & Carter, M. F. (1980). N, N-Diisopropyltryptamine (DIPT) and 5-methoxy-N, N-diisopropyltryptamine (5-MeO-DIPT). Two orally active tryptamine analogs with CNS activity. Communications in psychopharmacology, 4(5), 363-369.
  3. Muller, A. A. (2004). New drugs of abuse update: Foxy Methoxy. Journal of Emergency Nursing, 30(5), 507-508.