Nausea suppression can be described as a reduction in vomiting, stomach cramps, and general feelings of nausea.
A mostly comprehensive list of the most common substances which induce this effect can be found below:
5-HT3 receptor antagonists
Drugs which bind to 5-HT3 receptors in the central nervous system and gastrointestinal tract are known to reduce nausea by inhibiting binding to the receptor which induces vomiting.
- Dolasetron (Anzemet) can be administered in tablet form or in an injection.
- Granisetron (Kytril, Sancuso) can be administered in tablet (Kytril), oral solution (Kytril), injection (Kytril), or in a single transdermal patch to the upper arm (Sancuso).
- Ondansetron (Zofran) is administered in an oral tablet, orally dissolving tablet, orally dissolving film, or in an IV/IM injection.
- Tropisetron (Setrovel, Navoban) can be administered in oral capsules or in injection form.
- Palonosetron (Aloxi) can be administered in an injection or in oral capsules.
- Mirtazapine (Remeron) is an antidepressant that has antiemetic effects and is also a potent histamine H1 antagonist.
Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting or for those who are unresponsive to other agents. These may cause changes in perception, dizziness, and loss of coordination.
- Cannabis - In the United States, this is a Schedule I drug.
- Dronabinol (Marinol) is a Schedule III drug in the United States.
- Synthetic cannabinoids such as nabilone (Cesamet), the JWH series, or 5F-PB-22.
- Sativex is an oral spray containing THC and CBD. It is currently legal in Canada and a few countries in Europe, but is not legal in the United States.
- H1 histamine receptor antagonists are effective for many conditions including motion sickness, morning sickness in pregnancy, and to combat opioid nausea.
- Ginger contains the 5-HT3 antagonists gingerols and shogaols.
- Lemon essential oil is reported to be an effective anti-nausea agent. The oil can be consumed in a capsule or applied to the skin via a carrier oil.
- Emetrol is claimed to be an effective antiemetic.
- Propofol given intravenously has been used in an acute care setting in hospitals as a rescue therapy for emesis.
- Peppermint is claimed to help nausea or stomach pain when added into tea or peppermint candies.
- Ajwain is a popular nausea relieving spice in India, Ethiopia and Eritrea.
Compounds within our psychoactive substance index which may cause this effect include:
Annectdotal reports which describe this effect with our experience index include:
- Responsible use
- Subjective effects index
- Psychedelics - Subjective effects
- Dissociatives - Subjective effects
- Deliriants - Subjective effects
- 69ron (2008). "Lemon essential oil: way more effective than ginger for treating nausea" Nature's Herb Forum.