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A prodrug is a medication or compound that, upon administration, becomes metabolized (i.e. converted in the body) into a pharmacologically active substance.[1] Inactive prodrugs are pharmacologically inactive medications that are metabolized into an active form within the body.

Prodrugs may be subject to a rate-limiting step in the conversion from inactive to active substance: in which case, only the duration, and not the intensity of the effect increases. Additionally, they may display other differences relating to pharmacokinetic factors (i.e. how a substance is absorbed, distributed, metabolized and excreted) compared its nonprodrug form.[citation needed]











External links


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