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|Summary sheet: Risperidone|
|Molecular structure of Risperidone|
|Routes of Administration|
Risperidone (trade name Risperdal) is an atypical antipsychotic medication used to treat schizophrenia, biploar disorder and irritability caused by autism. It is sometimes used as a sedative to reduce the effects of psychedelics like LSD and to induce sleepiness. Benzodiazepines are also used for this purpose.
Risperidone has a quite complex pharmacology, but its main mechanism of action is that it is a D2 dopaminergic receptor antagonist, meaning it blocks dopamine from binding to the receptor, meanwhile not activating it. It also blocks most of the serotonin receptors, being an inverse agonist at the 5-HT2A, 5-HT2B, and 5-HT2C serotonin receptors. Risperidone has the strongest affinity to the 5-HT2A receptor. On top of that, it acts as an irreversible antagonist at the 5-HT7 serotonin receptor. Its hypnotic effects come from the blockade of dopamine D2 receptors.
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.
- The general head space of risperidone is often described as one of sleepiness, emptiness, apathy, stupor and catatonia. The specific cognitive effects can be broken down into several components which progressively intensify proportional to dosage. These are described below and generally include:
Toxicity and harm potential
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- United Kingdom: Risperidone is available only through prescription.
- United States: Risperidone is available only through prescription.
- Australia: Risperidone is available only through prescription.
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