Nausea can be described as a sensation of unease and discomfort in the upper stomach combined with an involuntary urge to vomit. It often, but not always, precedes vomiting. This effect usually occurs at the onset of the experience and dissipates as the peak takes its toll.
In the context of substance usage, nausea and vomiting can occur as a result of stomach irritation through the consumption of materials which it is not used to digesting. These materials can include things such as chemical powders or plant matter. Alternatively, nausea may occur as a direct pharmacological result of how the particular substance affects the brain. If this is the case, the nausea is therefore inseparable from the experience itself and will likely occur to varying extents regardless of the route of administration.
Nausea is often accompanied by other coinciding effects such as stomach bloating, stomach cramps, and dizziness. It is most commonly induced under the influence of heavy dosages of a wide variety of compounds, such as psychedelics, opioids, GABAergics, deliriants, dissociatives, and stimulants.
Vomiting, also known as purging, puking and throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. This effect typically occurs during the peak of a substance's effects. It can often greatly relieve the person's physical side effects once it is over. For example, under the influence of many hallucinogenic compounds, it is common for a person to feel that their trip has become significantly more enjoyable after the act of vomiting due to their uncomfortable stomach symptoms suddenly subsiding as a result.
It is worth noting that a person should not brush their teeth immediately after vomiting. This is because the corrosiveness of stomach acid combined with the abrasiveness of brushing can cause permanent damage to a person's teeth when repeated over time. Instead, a person should wash their mouth out with water, mouthwash, a water flosser, or a mixture of baking soda and water (to neutralise the acidity).
Compounds within our psychoactive substance index which may cause this effect include:
Anecdotal reports which describe this effect within our experience index include:
- Experience: 15mg 2C-B (oral) - A pleasant low-dose evening with Nexus
- Experience: 18 mg 2C-I - Visually intense and strong bodily sensations
- Experience: 200µg 1P-LSD (sublingual) + 12mg CBD - The Vortex of Empathy
- Experience: 25mg 2C-E (oral) - A mindblowing experience
- Experience: 36mg 4-AcO-DiPT - Truly, one for the psychedelic animals among us
- Experience: 40mg 5-MeO-DMT (oral) + 40mg MXE (oral) - Untitled
- Experience: 450 Datura seeds - Talking to Ghosts
- Experience: 80mg EPT - Bummer
- Experience: 80mg EPT - Slight improvement
- Experience:1064mgs - Fascinating DXM experience - Unusual effects
- Experience:12 mg AMT - Nicely Surprised
- Experience:150mg MDMA + 20mg 2C-B - I designed it this way myself
- Experience:170mg 4-AcO-DMT - Recklessness rewarded
- Experience:2 grams Psilocybe Cubensis + 2.7 grams Syrian Rue - The Psilohuasca Albino Fox
- Experience:2.5g Syrian rue + 6g Mimosa Hostilis - My first experience with unity
- Experience:20mg - A profound sense of oneness
- Experience:20mg Heroin - The Last Time I Shot Up
- Experience:225ug - Sheer Awe and Joy
- Experience:225ug LSD + 9g cubensis - Galactic Melt and the Meverse
- Experience:250 seeds - Harsh body load
- Experience:250mg DXM - DXM Itch and Trip Report
- Experience:25mg (insufflated) - Simultaneously amazing and horrible
- Experience:25mg - A labyrinth of organs and a storybook walk
- Experience:26mg - I begged the shroom aliens to kill me
- Experience:26mg - Stage 3 Trip
- Experience:2C-E (20mg, insufflated) - Mind=Blown
- Experience:2g Syrian rue + 1g Mimosa Hostilis - These voices are the building blocks of consciousness
- Experience:2mg 25C-NBOMe - Experimental trip to test personal limits of NBOMes
- Experience:3-MeO-PCP, LSD, Clonazolam, and Amphetamine - Excessive Amounts and Excessive Confusion
- Experience:300mg DPH + 600mg DXM - An Interesting Combo
- Experience:300µg ETH-LAD - Turned Inside Out
- Experience:3g Syrian Rue + 5g Acacia Confusa - Life Changing Madness
- Experience:3g mimosa / 2g syrian rue - I was the Universe's prophet
- Experience:4-HO-MET – 15 mg Insufflated
- Experience:40 mg 4-HO-MPT - Underwhelming Experience
- Experience:400mg DXM + 300mg DPH – Bacterial friends
- Experience:400mg and 300mg of fluorophenibut
- Experience:40mg + Syrian Rue (unknown dosage) - My one bad trip
- Experience:4F-EPH (15mg) - Untitled
- Experience:5 yopo seeds - Midnight Jungle
- Experience:50mg - How's the short-term memory?
- Experience:535mg - My First DXM Trip
- Experience:60mg 4-AcO-DMT + Syrian rue (3g) - Surrender
- Experience:60mg Zolpidem - A Delirious Adventure
- Experience:6g mimosa / 2.5 g syrian rue - Best cake I've had for a while
- Experience:700mg - Joining the 700 club
- Experience:75 mg - Good tunes feat. Jeb Bush
- Experience:750mg - Experiencing Void; Dissociation Of Reality And Self
- Experience:800 seeds LSA - My First Trip Ever
- Experience:A combination of 25mg 4-AcO-DMT and unknown amount of 6-APB (benzofury)
- Responsible use
- Subjective effects index
- Nausea suppression
- Psychedelics - Subjective effects
- Dissociatives - Subjective effects
- Deliriants - Subjective effects
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- Shulgin, A. T., Carter, M. F. (1980). "N, N-Diisopropyltryptamine (DIPT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT). Two orally active tryptamine analogs with CNS activity". Communications in Psychopharmacology. 4 (5): 363–369. ISSN 0145-5699.
- Muller, A. A. (October 2004). "New Drugs of Abuse Update: Foxy Methoxy". Journal of Emergency Nursing. 30 (5): 507–508. doi:10.1016/j.jen.2004.07.037. ISSN 0099-1767.