Anxiety suppression

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Anxiety suppression (also known as anxiolysis[1]) is a partial to complete suppression of a person’s ability to feel anxiety, general unease, and negative feelings of psychological tension.[2][3] The experience of this effect may decrease anxiety-related behaviours such as rumination, muscular tension, panic attacks, and restlessness. This typically results in feelings of extreme calmness and relaxation.

Anxiety suppression is often accompanied by other coinciding effects such as disinhibition and sedation. It is most commonly induced under the influence of moderate dosages of anxiolytic compounds which primarily include GABAergic depressants,[4][5] such as benzodiazepines,[6] alcohol,[7] GHB,[8] and gabapentinoids[9]. However, it can also occur to a lesser extent under the influence of a large variety of other pharmacological classes which include but are not limited to opioids, dissociatives,[10] and SSRIs.

Psychoactive substances

Compounds within our psychoactive substance index which may cause this effect include:

Experience reports

Anecdotal reports which describe this effect within our experience index include:

See also

External links


  1. Anxiolysis definition |
  2. Medications for Anxiety, Panic and Phobias (PsychCentral) |
  3. Anxiety medications explained (Psychology Today) |
  4. Lydiard, R. B. (2003). The role of GABA in anxiety disorders. The Journal of clinical psychiatry, 64, 21-27.
  5. Nuss, P. (2015). Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatric disease and treatment, 11, 165.
  6. Shader, R. I., & Greenblatt, D. J. (1993). Use of benzodiazepines in anxiety disorders. New England Journal of Medicine, 328(19), 1398-1405.
  7. Alcohol and Anxiety (healthline) |
  8. GHB: The First Authentic Antidepressant by Claude Rifat |
  10. Irwin, S. A., & Iglewicz, A. (2010). Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care. Journal of palliative medicine, 13(7), 903-908.