Talk:25E-NBOH

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Summary sheet: 25E-NBOH

25E-NBOH
Chemical Nomenclature
Common names	DMT, Dimethyltryptamine, Dmitri
Substitutive name	N,N-Dimethyltryptamine
Systematic name	2-(1H-Indol-3-yl)-N,N-dimethylethanamine
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Bioavailability x% - y% Threshold x - mg Light x - y mg Common x - y mg Strong x - y mg Heavy x mg + Duration Total x - y hours Onset x - y minutes Come up x - y minutes Peak x - y hours Offset x - y hours After effects x - y hours ⇣ Sublingual Dosage Bioavailability x% - y% Threshold x - mg Light x - y mg Common x - y mg Strong x - y mg Heavy x mg + Duration Total a - b hours Onset a - b minutes Come up a - b minutes Peak a - b hours Offset a - b hours After effects a - b hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

25E-NBOH (also known as 2C-E-NBOH and NBOH-2C-E) is novel synthetic psychedelic substance of the phenethylamine chemical class that produces an array of visually-dominant and stimulating psychedelic effects when administered.

The name 25E-NBOH, which is short-hand for 2C-E-NBOH, is a derivative of the phenethylamine psychedelic 2C-E.

It is worth noting that compounds of the NBOH family are not orally active and should be administered sublingually by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes.

Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25E-NBOH in humans. It has no history of human use before being sold online as a designer drug in 2011. It is closely related to members of the 25x-NBOMe series, which have been associated with many hospitalizations and deaths. Anecdotal reports suggest that this substance may be difficult to use safely due to its highly sensitive dose-response and unpredictable effects.

Chemistry

25E-NBOH or 2C-E-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-E. 25E-NBOH is a substituted phenethylamine with methoxy groups CH₃O- attached to carbons R₂ and R₅ and an ethyl chain bound to carbon R₄ of the phenyl ring. It differs from 2C-E structurally through a substitution on the amine (NH₂) with a 2-hydroxybenzyl (BOH) group. 25E-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R₂.

Pharmacology

Further information: Serotonergic psychedelic

25E-NBOH most likely has efficacy at the 5-HT_2A receptor where it acts as a potent agonist.

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Stimulation - In terms of its effects on the physical energy levels of the user, 25E-NBOH is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the user to move unless they choose to do so. For others, however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of MDMA and traditional stimulants such as amphetamine.
  • Perception of bodily lightness
  • Spontaneous physical sensations
  • Mouth numbing - Assuming the substance has been taken sublingually, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed.
  • Nausea - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as psilocin, LSD, 2C-E and 2C-I, this could actually be considered very mild in its intensity.
  • Temperature regulation suppression
    • Increased bodily temperature
  • Abnormal heartbeat
  • Increased heart rate
  • Increased blood pressure
  • Muscle contractions
  • Muscle cramps
  • Muscle tension
  • Gustatory hallucination
  • Vasoconstriction
  • Appetite suppression
  • Stomach cramps
  • Dehydration
  • Dry mouth
  • Difficulty urinating or Frequent urination
  • Restless legs
  • Pupil dilation
  • Headaches
  • Seizures

Visual effects

• Enhancements

  • Visual acuity enhancement
  • Colour enhancement
  • Pattern recognition enhancement
  • Magnification

  Suppressions

  • Frame rate suppression
  • Peripheral information misinterpretation

  Distortions

  • Drifting (melting, flowing, breathing and morphing)
  • Colour shifting
  • Colour replacement
  • Colour tinting
  • Depth perception distortions
  • Perspective distortions
  • Tracers
  • Diffraction
  • Brightness alteration
  • After images
  • Symmetrical texture repetition
  • Recursion
  • Scenery slicing

  Geometry

  The visual geometry produced by this substance is similar to LSD and can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colorful in scheme, glossy in color, sharp around the edges and equally angular as well as rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within 2C-I and most of the 2C-x family in general as well as completely on par with LSD, Psilocin and DMT at appropriately high dosages.

  25E-NBOH’s geometry leads reliably leads to Level 8A visual geometry with Level 8B remaining so far unconfirmed. It seems to consistently be able to build up in visual intensity when the user stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

  Hallucinatory states

  • Transformations
  • Machinescapes - This component is an uncommon effect that typically only occurs at very strong to heavy doses.
  • Internal hallucination - (settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)

Cognitive effects

• The head space of 25E-NBOH is described by many as one which is both insightful and relatively unaltered in its thought processes even at moderate to high dosages. Some users suggest that 25E-NBOH may be even more clearheaded than other drugs of the 25x-NBOH class. The most prominent of these cognitive effects generally include:
  • Analysis enhancement - This component is introspection dominant and consistently manifested only in the context of a non-social setting in which the user is alone.
  • Thought acceleration
  • Conceptual thinking
  • Anxiety & Paranoia
    • Feelings of impending doom
  • Empathy, affection, and sociability enhancement - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings are a little weaker and less sharp than those produced by substances such as MDMA and 2C-B but still often prove strong enough to provide long-lasting therapeutic effects.
  • Memory suppression
    • Ego death
    • Amnesia
  • Novelty enhancement
  • Immersion enhancement
  • Emotion enhancement
  • Increased sense of humor
    • Laughter fits
  • Increased music appreciation
  • Personal bias suppression
  • Increased libido
  • Time distortion
  • Wakefulness

Auditory effects

• • Auditory enhancement
  • Auditory distortion
  • Auditory hallucination

Multi-sensory effects

• • Dosage independent intensity -
  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Transpersonal effects

• While they are occasionally reported, the transpersonal effects produced by this substance seem to be significantly less consistent and reproducible than other psychedelics, which perhaps corresponds with the notably mild changes to one's perceptual and cognitive processes.
  • Existential self-realization
  • Unity and interconnectedness

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

• Erowid Experience Vaults: 25E-NBOH

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

25E-NBOH is a relatively new substance, and little is known about its toxicity or interaction with other substances. It is assumed to pose similar acute health risks as 25E-NBOMe and other members of 25x-NBOMe series. The LD₅₀ has not yet been determined although it is likely to be potentially fatal at heavy dosages.

25E-NBOH's extreme potency means it should not be insufflated (snorted) as this method of administration has been associated with many deaths and hospitalizations with closely related members of the 25x-NBOMe series.

Tolerance and addiction potential

25E-NBOH is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 25E-NBOH is built almost immediately after ingestion. After that, it takes about 1 week for the tolerance to be reduced to half and 2 weeks to be back at baseline (in the absence of further consumption). 25E-NBOH presents cross-tolerance with all psychedelics, meaning that after the consumption of 25E-NBOH all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
• Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 25E-NBOH. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
• Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.
• Tramadol - Tramadol is well-documented to lower the seizure threshold and psychedelics may act to trigger seizures in susceptible individuals.

See also

• Responsible use
• Research chemical
• Psychedelics
• Phenethylamines
• 25x-NBOH
• 25D-NBOMe