Increased bodily temperature
Increased bodily temperature or pyrexia (which includes fever and hyperthermia) is defined as having a bodily temperature above normal baseline. The typical average temperature of a person is around 37°C (98.6°F). While there is no agreed upon value in which pyrexia is labeled, it ranges between 37.5 - 38.3°C (99.5 - 100.9°F). It is frequently associated with increased perspiration (sweating).
Pyrexia that exceeds 41.5°C (106.7°F) is labeled as hyperpyrexia and is a medical emergency potentially resulting in physical injury, long-term side effects, and death.
Elevated body temperature can be classed into two different cases:
- Fever is used to describe the body raising its core temperature due to illness. For example, a fever may be caused by a bacterial infection.
- Hyperthermia is classified as an uncontrollable increase in body temperature that typically originates from an external source. This most frequently involves heat strokes or the use of certain drugs.
A large number of drugs in multiple classes are capable of causing this effect, and thermoregulation is a complex process involving many physiological systems and is therefore very common. Serotonin and 5-HT receptors, dopamine and D receptors and norepinephrine have a significant effect.
Serotonin syndrome is a potentially life-threatening drug reaction that results from an overdose or inadvertent drug reactions such as combining SSRIs and MAOIs. It is associated with high fever among other symptoms and is often regarded as a medical emergency.
Compounds within our psychoactive substance index which may cause this effect include:
- Fever (Wikipedia) | https://en.wikipedia.org/wiki/Fever
- Hyperthermia (Wikipedia) | https://en.wikipedia.org/wiki/Hyperthermia
- Hyperpyrexia | https://en.wikipedia.org/wiki/Fever#Hyperpyrexia
- Serotonin and thermoregulation | https://www.ncbi.nlm.nih.gov/pubmed/6793718
- Dopamine and thermoregulation | https://www.ncbi.nlm.nih.gov/pubmed/3001601
- Thermoregulation and Norepinephrine | http://science.sciencemag.org/content/165/3897/1030