A-PHP

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Not to be confused with A-PVP.
Summary sheet: A-PHP
A-PHP
Α-PHP.svg
Chemical Nomenclature
Common names α-PHP, alpha-PHP, PV7
Substitutive name alpha-Pyrrolidinohexiophenone
Systematic name 1-Phenyl-2-(pyrrolidin-1-yl)hexan-1-one
Class Membership
Psychoactive class Stimulant
Chemical class Cathinone / Pyrrolidinophenone
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
Threshold 1 mg
Light 2 - 5 mg
Common 5 - 10 mg
Strong 10 - 20 mg
Heavy 20+ mg
Duration
Total 2 - 5 hours
Onset 2 - 8 minutes
Peak 30 - 90 minutes
Offset 1 - 4 hours
After effects 1 - 8 hours
Oral
Dosage
Threshold 1 mg
Light 5 - 10 mg
Common 10 - 25 mg
Strong 25 - 40 mg
Heavy 40 mg +
Duration
Total 2 - 8 hours
Onset 2 - 20 minutes
Peak 1 - 2.5 hours
Offset 1 - 5 hours
After effects 1 - 48 hours



Insufflated
Dosage
Threshold 0.5 mg
Light 1 - 5 mg
Common 5 - 15 mg
Strong 15 - 25 mg
Heavy 25+ mg
Duration
Total 2 - 5 hours
Onset 10 - 30 minutes
Peak 20 - 45 minutes
Offset 30 - 90 minutes
After effects 2 - 4 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
Alcohol
MXE
Dissociatives
DXM
MDMA
Stimulants
25x-NBOMe
25x-NBOH
Tramadol
SNRIs
MAOIs
Serotonin releasers
SSRIs
5-HTP


alpha-Pyrrolidinohexiophenone (also known as PV-7, alpha-PHP, A-PHP, and α-PHP) is a lesser-known novel stimulant substance of the cathinone class. It is structurally related to MDPV and is one of the successors to the designer drug cathinone analog α-PVP.

It is being used and marketed as a replacement for α-PVP (known on the street as flakka) a few years following its ban, where it has come to substitute α-PVP in many parts of the world. While initially mass synthesized in Chinese industrial laboratories, a ban on α-PHP within China's borders has forced production to nations worldwide.[citation needed]

Subjective effects such as euphoria, thought acceleration, disinhibition and ego inflation. It generally comes in the form of either a fine powder or crystallized shards that can produce powerful but short-lived euphoric stimulant effects comparable to those of vaporized methamphetamine and cocaine. Like its cathinone predecessors, it is has gained notoriety for its tendency to induce compulsive redosing and addictive behaviors as well the ability to produce delusional states and psychosis when abused.[citation needed]

Very little data exists about the pharmacological properties, metabolism, and toxicity of α-PHP. It has recently become commonly marketed alongside research chemical stimulants like NEP and Hexen as a legal, grey-market alternative to a-PVP, and commercially distributed through online research chemical vendors.

It is highly advised to use harm reduction practices if using this substance.

Chemistry

α-PHP, or α-Pyrrolidinohexanophenone, is a compound of the substituted cathinone and substituted pyrrolidine chemical classes. Its structure is comprised of hexanal bound to a phenyl ring at the 1 position and the nitrogen of a pyrrolidine ring at the 2 position.

α-PHP is the longer chain homolog of α-PVP, possessing an additional carbon on the alkyl side chain.

Pharmacology

The mechanism of action of α-PHP is unknown. Aside from a substantially shorter duration, it is believed to act similarly to the designer drug pentedrone and α-PVP, which both act as a potent norepinephrine-dopamine reuptake inhibitors (NDRI),[1] although no substantial research on the pharmacology of this compound has yet been conducted.

This means it may effectively boost the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.

Subjective effects

In comparison to its predecessor α-PVP, this compound has been reported as inducing slightly less anxiety, uncomfortable side effects, euphoria, and an easier comedown.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
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Visual effects
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Cognitive effects
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Multi-sensory effects
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After effects
Aftereffects (3).svg

Experience reports

There are currently 1 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

Toxicity and harm potential

Ambulance2.png

This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational α-PHP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because α-PHP has very little history of human usage. Anecdotal evidence from people who have tried α-PHP within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

α-PHP has been reported to be the cause, or a significant contributory cause, of death in suicides and overdoses caused by combinations of drugs.[2]

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

As with other short-lived highly dopaminergic stimulants, the chronic use of α-PHP can be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of α-PHP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). α-PHP presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of α-PHP all stimulants will have a reduced effect.

Psychosis

Main article: Stimulant psychosis

α-PHP, like other strongly dopaminergic stimulants, can result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions).[3][4] A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely.[4][5] The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.[4]

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

  • 25x-NBOMe & 25x-NBOH - 25x compounds are highly stimulating and physically straining. Combinations with A-PHP should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
  • Alcohol - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
  • DXM - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
  • MDMA - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
  • MXE - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
  • Dissociatives - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
  • Stimulants - A-PHP may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
  • Tramadol - Tramadol is known to lower the seizure threshold[6] and combinations with stimulants may further increase this risk.

Serotonin syndrome risk

Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

Legal status

Internationally, α-PHP was added to the UN Convention on Psychotropic Substances as a Schedule II controlled substance in March 2020.[8][9]

  • Austria: α-PHP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
  • Brazil: As of September 7, 2018, all cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.[10]
  • China: α-PHP is a controlled substance in China as of October 2015.[11]
  • Germany: α-PHP is a controlled substance under the BtmG (Betäubungsmittelgesetz)[12] as of Dezember 21, 2022.[13] Possession, production, sales and consumption is illegal and penalized.
  • Italy: The President of the Republic of Italy classified cathinone and all structurally derived analogues (including pyrovalerone analogues) as Narcotics in January 2012. [14]
  • Netherlands: As of October 29, 2021, α-PHP has been banned in the Netherlands under the 1971 Vienna Convention on Psychotropic Substances. [15]
  • Sweden: α-PHP is classified as narcotic substance.[16]
  • Switzerland: α-PHP can be considered a controlled substance as a defined derivative of Cathinone under Verzeichnis E point 1. It is legal when used for scientific or industrial use.[17]
  • United Kingdom: is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.[18]
  • United States: α-PiHP has been assigned to Schedule I on a Temporary Placement basis. This order, which extends the temporary scheduling order that DEA previously issued for these substances (84 FR 34291, July 18, 2019), is effective July 18, 2021 and expires on July 18, 2022. .[19] As such, the sale or the use of this compound is prohibited.

See also

External links

References

  1. Meltzer, P. C., Butler, D., Deschamps, J. R., Madras, B. K. (23 February 2006). "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogs. A promising class of monoamine uptake inhibitors". Journal of medicinal chemistry. 49 (4): 1420–1432. doi:10.1021/jm050797a. ISSN 0022-2623. 
  2. Klavž, J., Gorenjak, M., Marinšek, M. (1 August 2016). "Suicide attempt with a mix of synthetic cannabinoids and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alpha-PVP and 4-CMC". Forensic Science International. 265: 121–124. doi:10.1016/j.forsciint.2016.01.018. ISSN 0379-0738. 
  3. National Institute on Drug Abuse, Emerging Trends 
  4. 4.0 4.1 4.2 Shoptaw, S. J., Kao, U., Ling, W. (21 January 2009). Cochrane Drugs and Alcohol Group, ed. "Treatment for amphetamine psychosis". Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD003026.pub3. ISSN 1465-1858. 
  5. Hofmann, F. G. (1983). A handbook on drug and alcohol abuse: the biomedical aspects (2nd ed ed.). Oxford University Press. ISBN 9780195030563. 
  6. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN 1937-6995. ISSN 1556-9039. OCLC 163567183. 
  7. Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi:10.1093/bja/aei210Freely accessible. eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647. 
  8. "WHO: World Health Organization recommends 12 NPS for scheduling". December 2019. Retrieved October 16, 2020. 
  9. "CND accepts all WHO recommendations on the control of several psychoactive substances from the 42nd ECDD meeting". World Health Organization (WHO). March 18, 2020. Retrieved October 16, 2020. 
  10. New blanket ban on synthetic illegal drugs is approved (Portuguese) | http://portal.anvisa.gov.br/noticias/-/asset_publisher/FXrpx9qY7FbU/content/combate-a-drogas-ilicitas-sinteticas-fica-mais-facil/219201/pop_up?_101_INSTANCE_FXrpx9qY7FbU_viewMode=print&_101_INSTANCE_FXrpx9qY7FbU_languageId=pt_BR
  11. http://www.sfda.gov.cn/WS01/CL0056/130753.html
  12. "AnlageII BtmG" (in German). Bundesministerium der Justiz und für Verbraucherschutz.  Text "urlhttps://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html" ignored (help);
  13. "Änderung des BtMG mit Aufnahme von vier neuen NPS in Kraft getreten" (in German). Retrieved May 30, 2023.  Text "publisherBeck Community" ignored (help)
  14. http://www.politicheantidroga.it/media/491607/decreto%20ministero%20salute%2029%20dicembre%202011.pdf
  15. "Tractatenblad van het Koninkrijk der Nederlanden - 77 (1971), Nr. 7, A. TITEL, Verdrag inzake psychotrope stoffen;Wenen, 21 februari 1971". Retrieved 2021-10-29. 
  16. http://rkrattsbaser.gov.se/sfst?fritext=alfa-PHP&upph=false&sort=desc&post_id=2
  17. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  18. The Misuse of Drugs Act 1971 (Amendment) Order 2010 
  19. "Schedules of Controlled Substances Extension". Drug Enforcement Administration. Retrieved 2022-04-22.