|Summary sheet: 2C-T-7|
|Common names||2C-T-7, Beautiful, Blue Mystic, 7th Heaven|
|Routes of Administration|
2,5-Dimethoxy-4-propylthiophenethylamine (also known as 2C-T-7, Blue Mystic, and Beautiful, among others) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic and entactogenic effects when administered.
2C-T-7 was first synthesized by Alexander Shulgin and documented in his book PiHKAL ("Phenethylamines I Have Known and Loved"). It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.
In contrast to other members of the 2C-x family, 2C-T-7 has gained a reputation of being an unpredictable, dose-sensitive psychedelic capable of producing strong visual effects and an intense body load, which can manifest as a dangerous delirium in extreme cases. Many reports indicate that the physical effects are too severe for inexperienced users or those with pre-existing medical conditions.
This particular compound is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which -- with the exception of mescaline -- he designed, synthesized and tested on himself. They can be found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 4 Toxicity and harm potential
- 5 Legal status
- 6 See also
- 7 Literature
- 8 External links
- 9 References
2C-T-7, or 2,5-dimethoxy-4-propylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain.
2C-T-7 belongs to the 2C family of phenethylamines, which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T-7 is also substituted at R4 with a propyl thioether group.
2C-T-7 is analogous to 2C-T-2; the two differ by the length of the alkane chain in their thioether functional group.
2C-T-7's psychedelic effects have been shown to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
With serious adverse effects seen on overdoses of this compound (potentially Serotonin Syndrome) and as the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase A inhibitor and many of the amphetamine-analogs of the 2C-T-x series are highly selective MAO-A inhibitors (with ALEPH-7 being one of the most potent), this substance is widely thought to also have MAOI effects.
|This subjective effects section is a stub.|
As such, it is still in progress and may contain incomplete or wrong information.
You can help by expanding or correcting it.
Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
- Stimulation - In terms of its effects on the physical energy levels of the user, 2C-T-7 is generally considered to be energetic and stimulating in a fashion is comparable to that of other phenethylamines such as 2C-B, 2C-E and 2C-P. However, at certain doses and contexts, it may produce periods of notable sedation.
- Spontaneous physical sensations - The "body high" of 2C-T-7 is intense, but in comparison to 2C-E or 2C-B, it can be considered mild though is still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the "body high" experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
- Bodily control enhancement - Although this component is capable of manifesting itself in a distinct and noticeable fashion, for most users it does not generally seem to be as apparent or intense as the same component found within LSD and 2C-B.
- Changes in felt bodily form
- Tactile enhancement
- Temperature regulation suppression
- Abnormal heartbeat
- Increased blood pressure
- Increased heart rate
- Difficulty urinating or Frequent urination
- Increased perspiration
- Muscle contractions
- Muscle spasms
- Muscle cramps
- Nausea - Mild to extreme nausea is commonly reported when consumed in moderate to high dosages, and either passes once the user has vomited or gradually fades by itself as the peak sets in.
- Stomach bloating
- Stomach cramps
- Teeth grinding
- Excessive yawning
- Pupil dilation
- Watery eyes
- Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and extremely realistic in style but with a subtle digital/cartoonish form.
- After images
- Symmetrical texture repetition
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel with slightly more mystical and shamanic undertones in comparison to other phenethylamines. At higher dosages, they are equally likely to result in states of Level 8A visual geometry or Level 8B. There seems to be a visual geometry that is extremely similar to 2C-E and 2C-P and can be described as equal in intensity or complexity and equal in proportion to the accompanying cognitive and physical effects.
2C-T-7 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- The head space of 2C-T-7 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
As of August 2007, there have been at least three reported deaths associated with the use of 2C-T-7. These incidents occurred with insufflated doses of 30 mg or more, or in combination with stimulants such as MDMA,. There have also been a number of reports describing concerning physical side effects and hospitalizations, typically following insufflation.
It is strongly discouraged to administer 2C-T-7 non-orally because this can cause vomiting, numerous negative side effects, or death at high doses. In Erowid's Fall 2000 2C-T-7 survey, it was reported that the insufflation of 2C-T-7 resulted in more negative side effects than oral administration.
Tolerance and addiction potential
2C-T-7 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 2C-T-7 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-7 presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T-7 all psychedelics will have a reduced effect.
Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.
If 2C-T-7 does have MAOI effects as commonly speculated, this could indicate that 2C-T-7 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics. This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:
- Australia: In Australia, 2C-T-2 and 2C-T-7 are covered by the country's analog drug laws.
- Austria: 2C-T-7 is illegal to possess, produce and sell under the SMG. (Suchtmittelgesetz Österreich)
- Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
- Canada: 2C-T-7 is considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
- China: As of October 2015 2C-T-7 is a controlled substance in China.
- Germany: 2C-T-7 is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of July 1, 2001. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
- Latvia: 2C-T-7 is a Schedule I controlled substance in Latvia.
- The Netherlands: The Netherlands was the first country in the world to ban 2C-T-7 after being sold in smart shops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market but was soon banned as well. 2C-T-7 is a list I drug of the Opium Law.
- Sweden: The drug is Schedule I in Sweden. 2C-T-7 was first classified as a health hazard under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated as "the Act on the Prohibition of Certain Goods Dangerous to Health") that made it illegal to sell or possess as of April 1, 1999.
- Switzerland: Possession, production and sale is illegal.
- United Kingdom: 2C-T-7 is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
- United States: On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA. On March 18, 2004, the DEA published a final rule in the Federal Register which permanently placed 2C-T-7 in Schedule I.
- Hardison, C. (2000). An amateur qualitative study of 48 2C-T-7 subjective bioassays. MAPS Bulletin, 10(11).
- Third Confirmed 2C-T-7 Death by Erowid Apr 10, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death3.shtml
- A Reported 2C-T-7 Death by Erowid July 2003 | https://www.erowid.org/chemicals/2ct7/2ct7_death1.shtml
- Second Reported 2C-T-7 Death by Erowid Apr 2, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death2.shtml
- Zimmerman, M.M., “The identification of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7).” Microgram, Vol. XXXIV, No. 7, July 2001, pp. 169-173.
- https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
- https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
- Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats | http://link.springer.com/article/10.1007%2Fs00213-005-0009-4
- Wagmann, Lea; Brandt, Simon D.; Stratford, Alexander; Maurer, Hans H.; Meyer, Markus R. (2019). "Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases". Drug Testing and Analysis. 11 (2): 318–324. doi:10.1002/dta.2494. ISSN 1942-7603.
- Curtis, B., Kemp, P., Harty, L., Choi, C., & Christensen, D. (2003). Postmortem identification and quantitation of 2, 5-dimethoxy-4-n-propylthiophenethylamine using GC-MSD and GC-NPD. Journal of analytical toxicology, 27(7), 493-498.
- 2C-T-7 Overdoses & Delirium | https://www.erowid.org/chemicals/2ct7/2ct7_effects.shtml#overdose
- Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
- Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- "Fünfzehnte Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
- "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
- United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made