2C-T-7

From PsychonautWiki
(Redirected from 2ct7)
Jump to: navigation, search
Dialog-warning.svg.png

Death and serious injury may occur when 2C-T-7 is insufflated or combined with certain substances and medications (e.g. MAOIs or RIMAs)[1][2][3]

It is strongly discouraged to insufflate (snort) 2C-T-7, administer it non-orally, eyeball, or combine it with certain other substances. Please see this section for more details.

Summary sheet: 2C-T-7
2C-T-7
The skeletal formula of 2C-T-7.
2C-T-7.svg
Chemical Nomenclature
Common names 2C-T-7, Blue Mystic, 7th Heaven
Substitutive name 2,5-Dimethoxy-4-(propylthio)phenethylamine
Systematic name 2-[2,5-Dimethoxy-4-(propylsulfanyl)phenyl]ethan-1-amine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 3 - 10 mg
Light 10 - 15 mg
Common 15 - 25 mg
Strong 25 - 40 mg
Heavy 40 mg +
Duration
Total 6 - 10 hours
Onset 60 - 90 minutes
Come up 10 - 30 minutes
Peak 3 - 5 hours
Offset 1 - 3 hours
After effects 2 - 8 hours



Insufflated
Dosage
Threshold 1 - 2 mg
Light 2 - 5 mg
Common 5 - 10 mg
Strong 10 - 15 mg
Heavy 15 - 25 mg 2C-T-7 has been fatal when insufflated at heavy doses of 30mg or higher.
Duration
Total 3 - 7 hours
Onset 5 - 15 minutes
Come up 20 - 60 minutes
Peak 2 - 4 hours
Offset 1 - 2 hours
After effects 1 - 2 hours






DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

2,5-Dimethoxy-4-propylthiophenethylamine (also known as 2C-T-7, Blue Mystic and 7th Heaven, among others) is a synthetic psychedelic substance of the phenethylamine chemical class that produces psychedelic and entactogenic effects when administered. It is a member of the 2C-x family of psychedelic phenethylamines, all of which are derivatives of mescaline.

2C-T-7 was first synthesized by Alexander Shulgin and documented in his book PiHKAL ("Phenethylamines I Have Known and Loved").[4]

It is considered by the community as a highly unpredictable dose sensitive psychedelic that has gained a reputation for its strong, potentially blinding visuals and intense body load that can manifest as fever-like delirium in extreme cases. Many reports indicate that the physical effects are too severe for those who are not already experienced with psychedelics or who have pre-existing medical conditions.

This particular substance is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which -- with the exception of mescaline -- he developed, synthesized and tested on himself. They can be found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.[5]

Chemistry

2C-T-7, or 2,5-dimethoxy-4-propylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain.

2C-T-7 belongs to the 2C family of phenethylamines, which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T-7 is also substituted at R4 with a propyl thioether group.

2C-T-7 is analogous to 2C-T-2; the two differ by the length of the alkane chain in their thioether functional group.[6]

Pharmacology

Further information: Serotonergic psychedelic

2C-T-7's psychedelic effects have been shown to come from its efficacy at the 5-HT2A receptor as a partial agonist.[7] However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

As the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase A inhibitor, this substance is widely thought to have MAOI effects.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death.

Physical effects
Child.svg

Visual effects
Eye.svg

Cognitive effects
User.svg

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

There have been at least three reported deaths related to 2C-T-7 use as of August 2007, mainly at insufflated doses of 30 mg or more[citation needed] or combined with stimulants such as MDMA,[citation needed] as well as a number of very uncomfortably intense effects and hospitalizations due to the insufflation of 2C-T-7.[8]

It is strongly discouraged to administer 2C-T-7 non-orally because this can cause vomiting, numerous negative side effects, or death at high doses. In Erowid's Fall 2000 2C-T-7 survey, it was reported that the insufflation of 2C-T-7 resulted in more negative side effects than oral administration.[citation needed]

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the accurate administration of the intended dose.

Tolerance and addiction potential

2C-T-7 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T-7 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-7 presents cross-tolerance with all psychedelics, meaning that after the consumption of 2C-T-7 all psychedelics will have a reduced effect.

Dangerous interactions

If 2C-T-7 does have MAOI effects as commonly speculated, this could indicate that 2C-T-7 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[9] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

Legality

  • Australia - In Australia, 2C-T-2 and 2C-T-7 are covered by the country's analog drug laws.[citation needed]
  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[10]
  • Canada: 2C-T-7 is considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[11]
  • China - As of October 2015 2C-T-7 is a controlled substance in China.[12]
  • Germany - 2C-T-7 is scheduled in Germany.[citation needed]
  • Latvia - 2C-T-7 is a Schedule I controlled substance in Latvia.[13]
  • Netherlands - The Netherlands was the first country in the world to ban 2C-T-7 after being sold in smart shops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market but was soon banned as well. 2C-T-7 is a list I drug of the Opium Law.[citation needed]
  • Sweden - The drug is Schedule I in Sweden.[14] 2C-T-7 was first classified as a health hazard under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated as "the Act on the Prohibition of Certain Goods Dangerous to Health") that made it illegal to sell or possess as of April 1, 1999.[citation needed]
  • Switzerland: Possession, production and sale is illegal.[15]
  • United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[16]
  • United States - On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA. On March 18, 2004, the DEA published a final rule in the Federal Register which permanently placed 2C-T-7 in Schedule I.[citation needed]

See also

External links

References

  1. Third Confirmed 2C-T-7 Death by Erowid Apr 10, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death3.shtml
  2. A Reported 2C-T-7 Death by Erowid July 2003 | https://www.erowid.org/chemicals/2ct7/2ct7_death1.shtml
  3. Second Reported 2C-T-7 Death by Erowid Apr 2, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death2.shtml
  4. https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
  5. https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
  6. http://isomerdesign.com/PiHKAL/read.php?id=43
  7. Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats | http://link.springer.com/article/10.1007%2Fs00213-005-0009-4
  8. 2C-T-7 Overdoses & Delirium | https://www.erowid.org/chemicals/2ct7/2ct7_effects.shtml#overdose
  9. Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
  10. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  11. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
  12. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
  13. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  14. http://www.lakemedelsverket.se/upload/lvfs/LVFS_2004-3.pdf
  15. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  16. Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted