Sedation can be described as a decrease in a person's physical energy levels which are interpreted as discouraging when it comes to wakefulness, movement, performing tasks, talkativeness, and general exercise. At lower levels, sedation typically results in feelings of general relaxation and a loss of energy. At higher levels, however, sedation typically results in the person passing out into temporary unconsciousness.
This effect is capable of manifesting itself across the 4 different levels of intensity described below:
- Minimal sedation - At the lowest level, the person will feel subtly lower in energy and alertness. They will likely have an increased desire to sleep or at least relax in a manner which is typically possible to ignore.
- Moderate sedation - At this level, the person will begin to drift off to sleep. However, they will still respond to noises and physical sensations if they are particularly prominent or above usual noise levels.
- Deep sedation - At this level, the person will have drifted off into a deep sleep. They will typically be mostly unresponsive unless subjected to repeated or painful stimulation.
- General anaesthesia - At the highest level, the person will be completely unconscious. They will be completely unarousable even with repeated painful stimulus.
Sedation is often accompanied by other coinciding effects such as muscle relaxation, thought deceleration, and sleepiness in a manner which further intensifies the person's feelings of relaxation. It is most commonly induced under the influence of moderate dosages of depressant compounds, such as opioids, GABAergics, and antipsychotics. However, it may also occur to a lesser extent under the influence of other compounds such as cannabinoids and certain psychedelics.
Compounds within our psychoactive substance index which may cause this effect include:
- ... further results
Anecdotal reports which describe this effect within our experience index include:
- Experience: 15mg 2C-B (oral) - A pleasant low-dose evening with Nexus
- Experience: 22mg 2C-B (oral) / 100ug 1P-LSD (sublingual) - My first time tripping alone (2 days in a row)
- Experience: 36mg 4-AcO-DiPT - Truly, one for the psychedelic animals among us
- Experience: 450 Datura seeds - Talking to Ghosts
- Experience: 550mg DPH - My First Time on DPH
- Experience:1000mg / 1200mg / 1400mg / 1600mg - heroic doses
- Experience:1000mgs of U4700 over 8 days - A harmful substance
- Experience:1g of stars and love
- Experience:20mg Etizolam - Smoking Etizolam
- Experience:20mg Heroin - The Last Time I Shot Up
- Experience:225mg Pregabalin +Cannabis -Bliss and Serenity; a hedonistic evening
- Experience:25mg (insufflated) - Simultaneously amazing and horrible
- Experience:25mg - A labyrinth of organs and a storybook walk
- Experience:25mg Deschloroketamine - My first time orally dosing DCK
- Experience:25mg Quetiapine - Nice buzz
- Experience:2g Syrian rue + 1g Mimosa Hostilis - These voices are the building blocks of consciousness
- Experience:2mg Etizolam & N20 - "Hippy Crack" Indeed
- Experience:3-MEO-PCMo (420mg) - Trip Report
- Experience:3-MeO-PCP, LSD, Clonazolam, and Amphetamine - Excessive Amounts and Excessive Confusion
- Experience:3mg Etizolam - A Comedown Drug
- Experience:4-AcO-DMT (20mg) - High Weight, No Effects
- Experience:50mg - Diphenidine ride
- Experience:60mg Zolpidem - A Delirious Adventure
- Experience:700mg - Joining the 700 club
- Experience:DXM and Cannabis: 100mg - Unexpected Strong Trip
- Experience:Datura and nicotine smoked - 4 and ~15 hits; was actually quite pleasant
- Experience:LSA (20 HWBR seeds) – A pleasant adventure with a harsh body load
- Experience:Mushrooms and Snuff Films -- Trip Report (3.5 grams)
- Experience:Nutmeg (8 teaspoons) - My Mom Introduces Me To Genesis and Other Things
- Responsible use
- Physical fatigue
- Subjective effects index
- Psychedelics - Subjective effects
- Dissociatives - Subjective effects
- Deliriants - Subjective effects