2C-B

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Summary sheet: 2C-B
2C-B
Molecular structure of 2C-B
2C-B.svg
Chemical Nomenclature
Common names 2C-B, Nexus, Bees
Substitutive name 4-Bromo-2,5-dimethoxyphenethylamine
Systematic name 2-(4-Bromo-2,5-dimethoxyphenyl)ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 2 - 10 mg
Light 10 - 20 mg
Common 20 - 35 mg
Strong 35 - 55 mg
Heavy 55 mg +
Duration
Total 4 - 8 hours
Onset 45 - 75 minutes
Come up 15 - 30 minutes
Peak 2 - 4 hours
Offset 1 - 2 hours
After effects 2 - 4 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Bromo Mescaline, BDMPEA, Venus and commonly as 2C-B) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered. It is a popular member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.

2C-B was first synthesized by Alexander Shulgin in 1974[1] and its activity in humans described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[2] This particular substance is part of the so-called "magical half-dozen" which refers to Alexander Shulgin's self-rated most important phenethylamine compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.[3]

It first saw use among the psychiatric community as an adjunct in psychotherapy. It was considered one of the best substances for this purpose because of its short duration, relative absence of side effects, and comparably mild nature.[4] Shortly after becoming popular in the medical community, it became popular recreationally.[citation needed]

2C-B was first sold commercially as an aphrodisiac[5] under the trade name "Eros," which was manufactured by the German pharmaceutical company Drittewelle. For several years, it was available as tablets in Dutch smart shops under the name "Nexus."[citation needed] In modern times it is used as a recreational substance, psychotherapeutic aid, and an entheogen.[citation needed]

History and culture

2C-B was first synthesized and discovered by Alexander Shulgin in 1974. He later published his findings on 2C-B in his 1991 book PiHKAL, and included it among the "magical half dozen" of psychedelic phenethylamines he deemed most important.[6] In interviews, Alexander Shulgin has repeatedly declared it his favorite psychedelic trip.[7]

In the 1970s, 2C-B was used in patients by a small number of psychotherapists in the United States. These therapists reported the drug created a warm, empathetic bond between them and their patients. The therapists also said the drug helped break down a patient's ego defenses and inner resistances, allowing the patient to get in touch with suppressed emotions and repressed memories.[8] The gentle nature of 2C-B, in addition to its mild side effects and short duration, was found to be desirable traits for in the therapeutic setting.

Not long after the drug gained traction in the medical community, 2C-B became popular in the recreational drug scene. 2C-B was well liked as an MDMA substitute ideal for raves and parties with minimal comedown and a clear euphoric headspace.

In the 1980s and early 1990s, several foreign companies legitimately manufactured 2C-B under the brand names Nexus, Erox, and Performax and advertised that it would alleviate impotence, frigidity, and diminished libido. It was sold at adult book and video stores, "head" shops, and some nightclubs. The DEA reported it to be sold in Miami, FL as yellow pills marketed as an aphrodisiac.

After MDMA was classified as Schedule I by the United States in 1985, 2C-B gained popularity as an alternative to the now illegal party drug. Its increasing popularity caused it to be placed in Schedule I in 1995.[9] Its use has since seen a resurgence due to the advent of online research chemical vendors.

2C-B is used as entheogen by the Sangoma, Nyanga, and Amagqirha people over their traditional plants; they refer to the chemical as Ubulawu Nomathotholo, which roughly translates to "Medicine of the Singing Ancestors".[10]

Chemistry

Generic structure of a phenethylamine molecule

2C-B or 2,5-dimethoxy-4-bromophenethylamine is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-B contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring.

2C-B belongs to the 2C family of phenethylamines, all of which contain methoxy groups on the 2 and 5 positions of the benzene ring.[11]

Pharmacology

Further information: Serotonergic psychedelic

Unlike most psychedelics, 2C-B has been shown to be a low efficacy serotonin 5-HT2A receptor partial agonist[12] or even full antagonist.[13] This suggests that the 5-HT2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B.[14] Research also suggests that 2C-B increases dopamine levels in the brains of rats which may contribute to its psychoactivity.[15]

However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Visual effects
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Cognitive effects
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Multi-sensory effects
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Transpersonal effects
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Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Combinations

  • Cannabis - When used in combination with cannabis, both the visual and cognitive effects of 2C-B can be intensified and extended with extreme efficiency. This should be used with extreme caution if one is not experienced with psychedelics as this can also amplify the anxiety, confusion and psychosis producing aspects of cannabis significantly.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. Dissociative-induced holes, spaces, and voids while under the influence of 2C-B have significantly more vivid visuals than dissociatives alone present, and more intense internal hallucinations, and corresponding confusion which can spontaneously manifest as delusions and psychosis.
  • Nitrous - Nitrous oxide ("Laughing gas") is commonly used in combination with psychedelics. The two are known to possess powerful cross-synergistic effects, including the capacity to send the user directly into an "ego death" state. The speed and intensity with which this occurs is very rapid and the euphoria that can result often leads to the urge to compulsively redose.
  • MDMA - When used in conjunction with MDMA, the physical and cognitive effects of MDMA are amplified. The visual, physical and cognitive effects of 2C-B are also intensified with an overwhelming euphoric pleasure manifested through uniquely pleasurable body highs and headspaces, and uniquely colorful and awe-inspiring visuals. The synergy between these substances is unpredictable, and it is best to start with markedly lower dosages than one would take for both substances individually. Additionally, users should be aware that there are reasons to believe that this combination may result in unforeseen neurotoxic effects, so a strong sense of caution and independent research are highly advised if one decides to experiment with this combination.[citation needed]
  • Alcohol - This interaction is not typically recommended due to alcohol’s ability to cause dehydration and nausea and physical fatigue which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, reasonably safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically taxing way.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an 2C-B experience. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high dependence and addiction potential that benzodiazepines possess.
  • Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.

Toxicity and harm potential

The toxicity and long-term health effects of recreational 2C-B use do not seem to have been studied in any scientific context, and the exact toxic dose is unknown.

Anecdotal reports from those who have tried 2C-B suggest that there are no negative health effects attributed to simply trying it by itself at low to moderate doses or using it very sparingly (although nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

There is no current data for the LD50 of 2C-B, but it is thought to be considerably higher than the active dose. Alexander Shulgin reported a 100 mg oral dose taken without apparent harm.[16]

Tolerance and addiction potential

2C-B is non-addictive and the desire to use it can actually decrease with use.

Tolerance to the effects of 2C-B are not built almost immediately after ingestion as with other psychedelics. There are many anecdotal reports of people ingesting this substance many days in a row with no immediate tolerance build up.

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Legal status

  • Australia: Possession, production and sale is illegal.[citation needed]
  • Austria: 2C-B is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Belgium: Possession, production and sale is illegal.[citation needed]
  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[18]
  • The EU: 2C-B is a Schedule II drug.[citation needed]
  • Canada: 2C-B is a Schedule III drug.[19]
  • Italy: 2C-B is Schedule I (tabella I)[20]
  • Estonia: 2C-B is a Schedule I drug.[citation needed]
  • Finland: Possession, production and sale is illegal.[citation needed]
  • Germany: 2C-B is illegal to possess, produce and sell under the BtMG.[21]
  • Japan: Possession, production and sale is illegal.[citation needed]
  • The Netherlands: Possession, production and sale is illegal.[citation needed]
  • Latvia: 2C-B is a Schedule I controlled substance.[22]
  • Norway: 2C-B is a Schedule II drug.[citation needed]
  • Poland: 2C-B is a Schedule I drug.[citation needed]
  • Russia: Possession, production and sale is illegal.[citation needed]
  • Spain: 2C-B is a Category 2 drug.[citation needed]
  • Sweden: 2C-B is a Schedule I drug.[23]
  • Switzerland: Possession, production and sale is illegal.[24]
  • United Kingdom - 2C-B is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.[25]
  • United States: 2C-B is a Schedule I drug.[citation needed]

See also

External links

Community

Literature

  • González, D., Torrens, M., & Farré, M. (2015). Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions. BioMed Research International, 2015. https://doi.org/10.1155/2015/643878

References

  1. Shulgin A. T., Carter M. F. Centrally active phenethylamines. Psychopharmacology Communications. 1975;1(1):93–98. PMID: 1223994
  2. Shulgin, A., & Shulgin, A. (1991). Erowid Online Books: "PIHKAL" - #20 2C-B. Retrieved Oct 26, 2017.
  3. Shulgin, A., & Shulgin, A. (1991). Erowid Online Books: "PIHKAL" - The Chemical Story. Retrieved April 14, 2017.
  4. Erowid 2-CB effects | http://www.erowid.org/chemicals/2cb/2cb_effects.shtml
  5. 2C-B (Nexus) Reappears on the Club Drug Scene | http://www.justice.gov/archive/ndic/pubs0/665/665p.pdf
  6. Phenethylamines I Have Known And Loved http://isomerdesign.com/PiHKAL/read.php?id=20
  7. https://www.scientificamerican.com/article/self-experimenter-chemist-explores-new-psychedelics/
  8. http://www.encyclopedia.com/science/applied-and-social-sciences-magazines/2c-b-nexus
  9. https://www.justice.gov/archive/ndic/pubs0/665/
  10. http://www.tacethno.com/info/2cb/2cbhistory.html#South%20Africa
  11. http://isomerdesign.com/PiHKAL/read.php?id=20
  12. Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors | http://jpet.aspetjournals.org/content/321/3/1054
  13. http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04 | http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04
  14. http://jpet.aspetjournals.org/content/321/3/1054.full.pdf
  15. behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats | http://link.springer.com/article/10.1007%2Fs00213-012-2797-7
  16. "Shulgin, A (1991) PIHKAL" | http://www.erowid.org/library/books_online/pihkal/pihkal020.shtml
  17. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  18. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  19. "CDSA Schedule II" | http://isomerdesign.com/Cdsa/schedule.php?schedule=3&section=ALL&structure=C
  20. Italy drug schedule | http://www.salute.gov.it/medicinaliSostanze/paginaInternaMedicinaliSostanze.jsp?id=7&menu=strumenti
  21. BtMG Anlage I | https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html
  22. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  23. http://www.lakemedelsverket.se/upload/lvfs/LVFS_2009-22.pdf
  24. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  25. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made