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Summary sheet: Kanna
Chemical Nomenclature
Common names Kanna, Channa, Kougoed
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 50 mg
Light 100 - 150 mg
Common 150 - 200 mg
Strong 200 - 250 mg
Heavy 200 mg +
Total 1 - 2 hours
Onset 0 - 1 minutes
Peak 15 - 60 minutes
After effects 2 - 4 hours
Threshold 50 mg
Light 500 - 750 mg
Common 750 - 1500 mg
Strong 1500 - 2000 mg
Heavy 2000 mg +
Total 4 - 6 hours
Onset 30 - 60 minutes
Peak 3 - 4 hours

Threshold 50 mg
Light 50 - 100 mg
Common 100 - 150 mg
Strong 150 - 500 mg
Heavy 500 mg +
Total 1.5 - 3 hours
Onset 5 - 15 minutes
Peak 1 - 2 hours
Offset 30 - 60 minutes
After effects 2 - 6 hours
Threshold 50 mg
Light 50 - 75 mg
Common 75 - 100 mg
Strong 100 - 125 mg
Heavy 125 mg +
Total 30 - 90 minutes
Onset 0 - 5 minutes

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Sceletium tortuosum (also known as Kanna) is a succulent plant commonly found in South Africa. Many of its psychoactive effects are similar to but less intense than the effects of empathogens such as MDMA. It can be administered orally, insufflated, subilingually, smoked, or chewed.

Kanna is sometimes used as an anti-depressant as a replacement for pharmaceutical anti-depressants. A pharmaceutical company owns a patented extract of kanna called Zembrin which may begin to be prescribed for depression, anxiety, insomnia and other psychiatric disorders in the future.

History and culture

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Kanna was used by South African pastoralists and hunter-gatherers to enhance their mood and increase their energy.



This chemistry section is incomplete.

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The active compounds in kanna are mesembrine, mesembrenone, mesembrenol, and tortuosamine. It is believed that mesembrine and mesembrenone are responsible for the majority of kanna's effects.


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The main psychoactive effects of kanna are a result of its action as a potent serotonin reuptake inhibitor (SRI), a PDE4 inhibitor, and an upregulator of VMAT2 [1].

The VMAT2 upregulation produced by kanna is thought to be responsible for the effects of kanna as a stimulant and euphoriant, due to the increase of dopamine and noradrenaline. The potent SSRI activity and PDE4 inhibition are thought to be mainly responsible for the antidepressant, anxiolytic, and sedating effects produced by kanna.

Sites Mesembrine Mesembrenone
SERT 1.4 nM 27 nM
PDE4 7800 nM 470 nM

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

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Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Visual effects

Cognitive effects

Auditory effects

After effects
Aftereffects (3).svg

Combination effects

  • Alcohol - Kanna is reported to have strong synergy with alcohol, increasing the prococial effects of both substances as well as providing a strong sense of novelty enhancement and appreciation for nature. The warm body feelings of kanna are enhanced greatly with this combination, as are typical empathogenic desires for physical effection. Negative drawbacks to alcohol consumption such as irritability and tactile suppression are reduced whilst feelings of pain relief, muscle relaxation and motor control loss become more pronounced. Nausea and heartburn may be more of a risk for sensitive individuals and so those with a weak stomach should be cautious with their dosing. The visual effects of kanna are mostly reduced to color enhancement and a visual haze as the effects of alcohol seem to negate some of kanna's more hallucinogenic visual effects. It has been shown that SSRIs increase sensitivity to alcohol and may make the compound more neurotoxic than if it were taken on its own. For this reason, it is advised to use this combo sparingly if one should choose to try it

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Kanna is not known to be toxic on its own but it may be toxic when mixed with other substances that interact with serotonin or PDE4.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

A lethal dose of kanna on its own is not known to have occured, however it may be dangerous and even lethal when mixed with other substances.

Tolerance and addiction potential

Kanna is known to have a "reverse tolerance", similar to serotonergic antidepressants and kava kava, where in order to experience the strongest and most theraputic effects, a person must have taken kanna recently. This is often called "priming" and usually takes about a week of daily priming to experience the most intense effects. After about week of priming, continuing to use kanna at the same dose will not cause an increase or decrease in tolerance to its psychoactive effects.

Psychological dependence can be experienced with kanna, however is much less intense than the psychological dependence experienced with other stimulants such as amphetamine, and antidepressants such as fluoxetine. According to the manufacturers of Zembrin, kanna does not cause withdrawal symptoms, however some anecdotal reports describe mild physical withdrawal symptoms similar to, but less intense than the withdrawal symptoms experienced with SSRIs and stimulants.

Dangerous interactions


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As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit. Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

Kanna is not known to be controlled, regulated or illegal in any country except for the United States as well as the United Kingdom.

  • United States: Kanna is uncontrolled in the United States by federal law. This means all parts of the plant and its extracts are legal to cultivate, buy, possess, and distribute (sell, trade or give) without a license or prescription. If sold as a supplement, sales must conform to U.S. supplement laws. If sold for consumption as a food or drug, sales are regulated by the FDA.
    • Louisiana: Kanna is a controlled substance in Louisiana.[3] It is not controlled anywhere else in the United States.
  • United Kingdom: Kanna is illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 2016.[4]

See also

External links


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