Addiction suppression

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Addiction suppression can be described as the experience of a total or partial suppression of a psychological addiction to a specific substance and the cravings associated with it. This can occur as an effect which lasts long after the compound which induced it wears off or it can last only while the compound is still active. Addiction suppression is a rare effect that is most commonly associated with psychedelics[1], psilocin[2], LSD[3], ibogaine[4] and N-acetylcysteine (NAC).[5]

In terms of psychedelics, this effect seems to be primarily triggered by the psychological self-reflection that can manifest through a combination of effects. These primarily include analysis enhancement, personal bias suppression, and introspection. The intensity and effectiveness of this experience occurring under the influence of a psychedelic is unpredictable and depends on a variety of factors such as dosage, setting, state of mind, and a general willingness to change.

In comparison, N-acetylcysteine seems to suppress feelings of addiction in a more direct and consistent manner. This is thought to occur as a result of its action on glutaminergic and dopaminergic pathways which may reverse brain functions that have become disturbed by heavy drug addiction.[6] This mechanism has been shown to provide relief for those who struggle with compulsive redosing, reward behaviors and psychological cravings, and has been shown to positively reverse nicotine addiction[7], cocaine addiction[8], marijuana dependence.[9], and many other compulsive behaviors.[10]

Psychoactive substances

Compounds within our psychoactive substance index which may cause this effect include:

See also

References

  1. Psychedelics: entering a new age of addiction therapy | http://www.pharmaceutical-journal.com/news-and-analysis/features/psychedelics-entering-a-new-age-of-addiction-therapy/20066899.article#fn_link_1
  2. Pilot Study of the 5-HT2AR Agonist Psilocybin in the Treatment of Tobacco Addiction (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286320/
  3. Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/22406913
  4. Mind-altering drug could offer life free of heroin (New Scientist) | https://www.newscientist.com/article/mg21929313-900-mind-altering-drug-could-offer-life-free-of-heroin/
  5. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/16000629
  6. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/16000629
  7. The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756612/
  8. Safety and Tolerability of N-Acetylcysteine in Cocaine-Dependent Individuals (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513138/
  9. N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/20163391/
  10. Glutamate transmission in addiction (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/18675832/