LSA

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Summary sheet: LSA
LSA
LSA.svg
Chemical Nomenclature
Common names LSA, Ergine
Substitutive name d-Lysergic acid amide / d-Lysergamide
Systematic name (8β)-9,10-Didehydro-6-methyl-ergoline-8-carboxamide
Class Membership
Psychoactive class Psychedelic
Chemical class Lysergamide
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold Common Heavy
20 - 50 - 100 - 250 - 400 seeds
Light Strong
Duration
Total 5 - 10 hours
Onset 30 - 120 minutes
Peak 2 - 7 hours
Offset 1 - 2 hours
After effects 1 - 3 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide, and LSA) is a naturally-occurring psychedelic substance of the lysergamide class. LSA is an ergot alkaloid and the main psychoactive constituent of plants such as morning glory and Hawaiian baby woodrose.[citation needed] LSA has a similar chemical structure as LSD and shares some of its effects.

LSA was first described in 1932 as part of an investigation into ergot alkaloids. In 1947, it was synthesized and tested for human activity by Albert Hofmann. The intramuscular administration of a 500 microgram dose led to a "tired, dreamy state with an inability to maintain clear thoughts." After a short period of sleep, the effects were gone and normal baseline was recovered within five hours.[1]

Like other psychedelics, LSA is not considered to be addictive by the scientific community.[2] However, unpredictable adverse reactions such as uncontrollable anxiety, paranoia, delusions and psychosis can always occur, particularly among those who are predisposed to psychiatric disorders.[3] It is therefore highly advised to use the proper amount of precaution and harm reduction practices if using this substance.

Chemistry

LSA, or d-lysergic acid amide, is an alkaloid belonging to the lysergamide family. It contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure. The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group.

LSA is a chiral compound with two stereocenters at R5 and R8. LSA, also called (+)-D-LSA, has an absolute configuration of (5R, 8R). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to LSD, with the exception being that LSA lacks the diethyl substitution of LSD at RN of its carboxamide group.

Pharmacology

Further information: Serotonergic psychedelic

LSA's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of scientific investigation.

The notion that LSA is the primary psychedelic constituent in morning glory and Hawaiian baby woodrose seeds has been challenged as the effects of isolated synthetic LSA are reported to be only slightly psychedelic in nature. Therefore, it has been proposed that the overall experience may possibly be produced by a mixture of various lysergamide alkaloids (including iso-LSA and LSH) within these plant materials instead of a single psychoactive compound.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical effects
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Visual effects
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Cognitive effects
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Transpersonal effects
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Combinational effects

  • Cannabis - Cannabis powerfully extends and intensifies both the sensory and cognitive effects of LSA. These substances should be combined with extreme caution as it has been well-observed that they amplify the anxiety, confusion and psychosis risk each possess. Those who choose to use this combination are advised to start off with only a fraction of their usual cannabis dose and take at least 20-minute breaks between hits in order to avoid a spiraling negative reaction.
  • Dissociatives - Dissociatives greatly enhance the cognitive, visuals and general hallucinatory effects of LSA. Dissociative-induced holes, spaces, and voids while under the influence of LSA have significantly more vivid visuals than dissociatives alone, as well as more intense internal hallucinations, and corresponding confusion which can spontaneously manifest as delusions and psychosis.
  • MDMA - LSA amplifies the physical, cognitive, and euphoric effects of MDMA. The visual, physical and cognitive effects of LSA can also be intensified to the point of overwhelming euphoric pleasure manifested through unique body highs, mindscapes, and colorful and intricate visuals. The synergy between these substances is unpredictable, and it is advised to start with markedly lower dosages than one would take for both substances individually. The toxicity of this combination is unknown, although there is some evidence that suggests the neurotoxic effects of MDMA may become amplified.[4][5][6]
  • Alcohol - This combination is not typically recommended due to alcohol’s ability to cause dehydration and nausea and physical fatigue which can negatively affect a trip if taken in moderate to high dosages. This combination is, however, reasonably safe in low doses and can often "take the edge off" a trip as well as dull its psychedelic effects in a fashion somewhat similar to benzodiazepines, albeit in a more physically draining way.
  • Benzodiazepines - When used in combination with benzodiazepines, benzodiazepines can, depending on the dosage, slightly to completely reduce the intensity of the cognitive, physical and visual effects of an LSA trip. They are very efficient at stopping "bad trips" at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose due to the very high addictive potential that benzodiazepines possess.
  • Psychedelics - When used in combination with other psychedelics, each substance's physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.
  • MAOIs - MAO inhibitors, such as passionflower and syrian rue potentiate the visual and introspective effects of psychedelics. It is advised to take caution when combining MAOIs with psychedelics because they can increase the chance of having a bad trip and may dangerously interact with other substances, such as SSRIs and stimulants, as well as some psychedelics such as MDA.
  • Selective serotonin reuptake inhibitors (SSRIs) - SSRIs are reported to suppress the visual and cognitive effects of LSA.

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Natural plant sources

Although LSA is illegal in some countries, various seeds which contain it are readily available in many gardening stores. However, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea and body load if ingested. Methods for cleaning or de-coating the seeds are available, but are typically ineffective. The types of seeds listed below are can be purchased online without pesticide coatings.

Morning glory seeds (MGS)

Morning glory seeds

The seeds of many species of morning glory are known to contain lysergamide alkaloids such LSA.[7]

When using morning glory seeds, the doses for oral consumption are generally considered to be:

  • Threshold: 20 - 50 seeds / 1.5 g
  • Light: 50 - 100 seeds / 1.5 - 3 g
  • Common: 100 - 250 seeds / 3 - 6 g
  • Strong: 250 - 400 seeds / 6 - 10 g
  • Heavy: 400 seeds + / 10 g +

Hawaiian baby woodrose seeds (HBWR)

Hawaiian baby woodrose seeds

Hawaiian baby woodrose is a perennial climbing vine that is native to the Indian subcontinent and has since been introduced to numerous areas worldwide including Hawaii, Africa and the Caribbean. Its seeds may be consumed for their various lysergamide alkaloids such as LSA.[8]

When using Hawaiian baby woodrose seeds, the doses for oral consumption are generally considered to be:

  • Threshold: 1 - 3 seeds
  • Light: 3 - 5 seeds
  • Common: 5 - 7 seeds
  • Strong: 7 - 12 seeds
  • Heavy: 12 seeds +

Preparation methods

Preparation methods for this compound within our tutorial index include:

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational LSA use do not seem to have been studied in any scientific context and the exact toxic dose is unknown.

Anecdotal evidence suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Vasoconstriction

LSA should not be used regularly for long periods of time. When used repeatedly over a short period of time, LSA's vasoconstrictive effects build up while the psychoactive effects get weaker. A common sign of vasoconstriction build up can be described as a feeling of painful or uncomfortable legs.[9] This happens as a result of an insufficient amount of blood getting to the muscles. The upper leg muscles are the largest, most energy consuming muscles in the body and will feel sore if blood flow to them is lowered even slightly.[10]

When HBWR, morning glory seeds or pure LSA seeds are consumed and sore legs are experienced, a break has been reported to be helpful. With LSA it can take up to 3 days of abstinence to get back to vasoconstriction baseline.

Tolerance and addiction potential

LSA is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of LSA are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). LSA presents cross-tolerance with all psychedelics, meaning that after the consumption of LSA all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are safe to use on their own, they can become dangerous or even life-threatening when taken with other substances. The list below contains some potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses but still increase the possibility of injury of death. Independent research should always be conducted to ensure that a combination of two or more substances is safe before consumption.

Legal status

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Australia: LSA is illegal to produce, sell, and consume in Australia.[citation needed]
  • Austria: LSA-containing seeds are not regulated, thus are legal to possess, produce and sell.[citation needed]
  • Latvia: LSA itself is illegal. Although it isn't scheduled, it is controlled as an LSD structural analog. However, there is no information about LSA-containing seeds. In Latvia, plants are only illegal if they contain Schedule I controlled substances and LSA is not a Schedule 1 controlled substance.[12]
  • The Netherlands: The consumption, sale and possession of LSA is illegal.[citation needed]
  • New Zealand: The consumption, sale and possession of LSA is illegal. The plants and seeds of morning glory species are legal to possess, cultivate, buy and distribute.[citation needed]
  • Sweden: The consumption, sale and possession of LSA is illegal.[citation needed]
  • Turkey: The consumption, sale and possession of LSA is illegal. The plants and seeds of morning glory species are legal to possess, cultivate, buy and distribute.[citation needed]
  • United Kingdom: LSA is a Class A drug and categorized as a precursor to LSD.[citation needed]
  • United States: As a precursor to LSD, LSA is a DEA Schedule III drug,[citation needed] however seeds containing LSA can be purchased legally on the internet and from gardening stores.

See also

External links

Discussion

References

  1. #26. LSD-25 (LA-111, ergine, d-lysergamide) - TIHKAL | http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml
  2. Lüscher, C., & Ungless, M. A. (2006). The Mechanistic Classification of Addictive Drugs, 3(11). https://doi.org/10.1371/journal.pmed.0030437
  3. Strassman, R. J. (1984). Adverse Reactions to Psychedelic Drugs: A Review of the Literature. The Journal of Nervous and Mental Disease, 172(10), 577-595. PMID: 6384428
  4. Armstrong, B. D., Paik, E., Chhith, S., Lelievre, V., Waschek, J. A., & Howard, S. G. (2004). Potentiation of (DL)‐3, 4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptior partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939. Neuroscience Research Communications, 35(2), 83-95. https://doi.org/10.1002/nrc.20023
  5. Potentiation of MDMA-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists | https://indiana.pure.elsevier.com/en/publications/potentiation-of-34-methylenedioxymethamphetamine-induced-dopamine
  6. Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons. | https://www.ncbi.nlm.nih.gov/pubmed/17572501
  7. http://jama.jamanetwork.com/article.aspx?articleid=1165951
  8. http://www.sciencedirect.com/science/article/pii/S0379073809004745
  9. http://www.ncbi.nlm.nih.gov/pubmed/11128853
  10. http://animalsci.highwire.org/content/84/11/3167.short
  11. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
  12. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem | http://likumi.lv/doc.php?id=121086