Cocaine

Cocaine
Chemical Nomenclature
Common names	Cocaine, Coke, Crack, Blow, Girl, White, Snow, "Nose Candy"
Substitutive name	Benzoylmethylecgonine
Systematic name	Methyl (1R,2R,3S,5S)-3- (Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1] octane-2-carboxylate
Class Membership
Psychoactive class	Stimulant
Chemical class	Tropane alkaloid
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. Insufflated Dosage Threshold Common Heavy 5 - 10 - 30 - 60 - 90 mg Light Strong Bioavailability 60[1]-80%[2] Threshold 5 - 10 mg Light 10 - 30 mg Common 30 - 60 mg Strong 60 - 90 mg Heavy 90 mg + Duration Total 10 - 90 minutes Onset 15 - 45 seconds DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Cocaine (also known as benzoylmethylecgonine, and popularly as coke, snow, blow, white, among many others) is a crystalline tropane alkaloid that is extracted from the leaves of the coca plant.^[3] It produces classical stimulant effects such as stimulation, disinhibition, thought acceleration, and euphoria when administered.

The name comes from "coca" and the alkaloid suffix "-ine", forming "cocaine". This substance has notably short-lived effects and is classed as a stimulant, an appetite suppressant and a local anaesthetic. It is thought to be markedly more dangerous than other CNS stimulants, including the entire amphetamine drug class.^[4] Regular use has been linked to the development of permanent heart conditions and at high doses it can cause sudden cardiac death.^[5]

According to a 2007 United Nations report, cocaine is the second most widely used illicit substance in the world behind cannabis. In terms of user rates, Spain is the country with the highest rate of cocaine usage (3.0% of adults in the previous year).^[6] Other countries where the usage rate meets or exceeds 1.5% are the United States (2.8%), England and Wales (2.4%), Canada (2.3%), Italy (2.1%), Bolivia (1.9%), Chile (1.8%), and Scotland (1.5%).^[7]

Chemistry

Cocaine is a tropane alkaloid found in the leaves of the coca plant, Erythroxylum coca. It is most commonly consumed as the hydrochloride salt which is typically produced in clandestine laboratories. Cocaine decomposes when heated strongly so the freebase and hydrogen carbonate salts of cocaine, which have much lower boiling points compared to the hydrochloride salt, are typically used when the substance is to be vaporized and are known as cocaine base and crack respectively.

The chemical structure of cocaine consists of three parts; the hydrophilic methyl ester moiety and the lipophilic benzoyl ester moiety, which are located in place of the carboxylic acid and hydroxyl groups of ecgonine respectively. This structure allows for its rapid absorption through nasal membranes and blood-brain barrier. Cocaine can be produced synthetically but the complexity of tropane synthesis and the sophisticated equipment required compared to the relative ease of growing coca plants prevent synthesis being economically viable.

The presence of the two ester groups makes cocaine relatively unstable in warm, humid environments and cocaine stored in an open container or with a high moisture content will lose apparent potency over time due to hydrolysis to methyl ecgonine or benzoylecgonine.

Cocaine is structurally similar to atropine and scopolamine, which also contain the tropane moiety.

Pharmacology

The most extensively studied effect of cocaine on the central nervous system is the blockade of the dopamine transporter protein's function. This substance acts as a reuptake inhibitor and prevents dopamine from being recycled, causing excessive amounts to build up in the synapse, or junction between neurons. The result is an enhanced and prolonged post-synaptic effect of dopaminergic signaling at dopamine receptors on the receiving neuron. To a lesser extent, cocaine also exhibits functionally similar effects of reuptake inhibition upon the neurotransmitters of serotonin and noradrenaline.^[8] It is this sudden flood of neurotransmitters that causes cocaine’s characteristic high.

Cocaine is often adulterated when sold on black markets and this can significantly alter its effects on the body. Even when adulterants are pharmacologically inactive, their combination with the long-term perishability of cocaine due to moisture can lead to vastly differing apparent potencies between dosages of cocaine, and as such, it can be challenging to determine a "typical" recreational dose. Pure cocaine is very potent and generates perceptible local anesthetic effects from 1 mg and perceptible CNS stimulation from 5-7 mg, however in recreational settings much higher doses tend to be preferred.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: Cocaine

Forms

In order for cocaine (in plastic bag at bottom) to be converted to crack, several supplies are needed. Pictured here are baking soda (a commonly used base in making crack) a metal spoon, a tea light, and a cigarette lighter. The spoon is held over the heat source in order to "cook" the cocaine into crack.

• Cocaine paste: is a crude extract of the coca leaf which contains 40% to 91% cocaine sulfate along with companion coca alkaloids and varying quantities of benzoic acid, methanol, and kerosene.
• Salts: Cocaine is a weakly alkaline compound (an "alkaloid") and can, therefore, combine with acidic compounds to form various salts. The hydrochloride (HCl) salt of cocaine is by far the most commonly encountered, although the sulfate (-SO4) and the nitrate (-NO3) are occasionally seen. Different salts dissolve to a greater or lesser extent in various solvents. The hydrochloride salt is polar in character and quite soluble in water.
• Freebase: “Freebase” is the base form of cocaine, as opposed to the salt form. It is practically insoluble in water whereas hydrochloride salt is water soluble. This prevents cocaine in its basic form from being usable for sublingual usage and insufflation. Freebase cocaine can be treated with ethers, isopropyl alcohol, and hydrochloric acid to turn it into the salt form. ^[12]
• "Crack": Crack refers to a lower purity form of freebase cocaine that is usually produced by neutralization of cocaine hydrochloride with a solution of baking soda (sodium bicarbonate, NaHCO3) and water, producing a very hard/brittle, off-white-to-brown colored, amorphous material that contains sodium carbonate, entrapped water, and other by-products as the main impurities. Smoking or vaporizing cocaine and inhaling it into the lungs produces an almost immediate "high" that can be very powerful and addictive. This initial buildup of stimulation is known as a "rush". While the stimulating effects may last for hours, the euphoric sensation is very brief, prompting the user to smoke more immediately.
• Coca leaf infusions: Coca herbal infusion (also referred to as coca tea) is used in coca-leaf producing countries as much as any herbal medicinal infusion would be elsewhere in the world. The free and legal commercialization of dried coca leaves under the form of filtration bags to be used as "coca tea" has been actively promoted by the governments of Peru and Bolivia for many years as a drink having medicinal properties. The leaves are also very widely used by native populations for a variety of purposes including the treatment of altitude sickness.
• Coca leaf chewing: Chewing the leaves with lime is also common in producing regions, which numbs the mouth and causes mild stimulation.

Toxicity and harm potential

Radar plot showing relative physical harm, social harm, and dependence of cocaine^[13]

Occasional use of cocaine rarely causes permanent or severe trouble to the body and mind.^[14][15] In terms of neurotoxicity (as defined by the damage or death of cells in the brain in response to over-excitation or reactive oxidation caused by drugs), cocaine does not appear to exhibit these effects unlike certain other substances such as methamphetamine. Its extended use or abuse does, however, cause short-term down regulation of neurotransmitters.

The most potentially harmful physical effects of cocaine appear to be not neurological but cardiovascular. Severe cardiac adverse events, particularly sudden cardiac death, become a serious risk at high doses due to cocaine's blocking effect on cardiac sodium channels.^[16] Moreover, long-term cocaine use may result in cocaine-related cardiomyopathy.^[17]

Regular cocaine insufflation, the most popular method of ingestion, can have extremely adverse effects on one's nostrils, nose, and nasal cavities. These include a loss of the sense of smell, nosebleeds, difficulty swallowing, hoarseness, or a chronically runny nose.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

Susceptible individuals have died from as little as 30 mg applied to mucous membranes, whereas addicts may tolerate up to 5 grams daily.^[18]

Tolerance and addiction potential

As with other stimulants, the chronic use of cocaine can be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a serious risk with heavy recreational cocaine use but is unlikely to arise from typical medical use.

Tolerance to many of the effects of cocaine develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). Cocaine presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of cocaine all stimulants will have a reduced effect.

Withdrawal symptoms

After taking cocaine on a regular basis, some users will become addicted. When the drug is discontinued immediately, the user will experience what has come to be known as a "crash" along with a number of other cocaine withdrawal symptoms including paranoia, depression, anxiety, itching, mood swings, irritability, fatigue, insomnia, an intense craving for more cocaine, and, in some cases, nausea and vomiting. Some cocaine users also report having similar symptoms to schizophrenic patients and feel that their mind is scattered or incoherent. Some users also report a feeling of a crawling sensation on the skin also known as "coke bugs".

These symptoms can last for weeks or, in some cases, months. Even after most withdrawal symptoms dissipate most users feel the need to continue using the drug; this feeling can last for years and may peak during times of stress. About 30-40% of cocaine addicts will turn to other substances such as medication and alcohol after giving up cocaine.^{[citation needed]}

Psychosis

Cocaine has a similar potential to induce temporary psychosis^[19] with more than half of cocaine abusers reporting at least some psychotic symptoms at some point.^[20] Typical symptoms of sufferers include paranoid delusions that they are being followed and that their drug use is being watched accompanied by hallucinations that support the delusional beliefs.^[21] Delusional parasitosis with formication ("cocaine bugs") is also a fairly common symptom.^[21]

Cocaine-induced psychosis shows sensitization toward the psychotic effects of the drug. This means that psychosis becomes more severe with repeated intermittent use.^[22]

Dangerous interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

• Stimulants - When used in conjunction with other stimulants, the cardiovascular effects of cocaine such as increased heart rate become dangerously high. This is potentially fatal and severely increases the risk of cardiac arrest.
• Depressants - Because depressants counteract some of the physical effects of cocaine (and vice-versa), the combination can lead users to underestimate the extent of their intoxication and consume larger doses than they otherwise would. Cocaine and opioids is a particularly dangerous combination because cocaine has a short half-life relative to most opioid drugs and as the effects of cocaine wear off, physical side-effects of the opioid can increase resulting in a delayed overdose with serious respiratory depression being a potentially fatal risk.
• 25x-NBOMe - Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
• Alcohol - When used in conjunction with alcohol, a portion of the cocaine undergoes transesterification with ethanol rather than undergoing hydrolysis with water which results in the production of cocaethylene.^[23] This creates significant changes in subjective effects such as a longer duration and increased euphoria. Some studies suggest, however, that this could potentially increase the cardiotoxic effects of cocaine to dangerous and unpredictable levels. It is also dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• DXM - This combination may cause increased heart rate and panic attacks.
• MXE - Increased heart rate and blood pressure may occur.
• Tramadol - This combination can increase the risk of seizures.
• MDMA - The neurotoxic and cardiotoxic effects of MDMA may be increased when combined with cocaine.^{[citation needed]} Additionally, the administration of cocaine before MDMA is reported to decrease its subjective effects and intensity. This is likely because both need to bind to the same reuptake transporters to produce their effects.^{[citation needed]}
• MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.^[24]
• Nicotine - Many cocaine users find that consumption of tobacco products during cocaine use enhances the euphoria because nicotine increases the levels of dopamine in the brain. This, however, may have undesirable consequences such as uncontrollable chain smoking during cocaine use (even users who do not smoke cigarettes have been known to chain smoke when using cocaine) in addition to the detrimental health effects and the additional strain on the cardiovascular system caused by tobacco.

Legal status

• Australia: Cocaine is a Schedule 8 (controlled) drug permitting some medical use, but is otherwise outlawed.^{[citation needed]}
• Austria: Cocaine is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich)..^{[citation needed]}
• Bolivia: Limited cultivation of coca is legal in Bolivia, where chewing the leaves and drinking coca tea are considered cultural practices, in particular, in the mountainous regions. Processed cocaine is illegal.^{[citation needed]}
• Brazil: Cocaine is often sold openly in stores, but it still remains illegal. In most cases, the stores will pay off the police to look the other way.^{[citation needed]}
• Canada: Cocaine is a Schedule I drug under the Controlled Drugs and Substances Act of Canada.^[25]
• Colombia: In 1994, possession of 1 gram of cocaine was legalized for personal use.^[26][27] Sale remains illegal, but personal production or gifts of cocaine are permitted.^{[citation needed]}
• Germany: Possession of cocaine without a medical prescription is illegal. Small amounts for self-consumption may go unpunished for the first time or non-regular offenders. This also varies by state. Usually, revocation of a driving license will follow up the confiscation of any drug except marijuana, since drug users are considered a risk to road traffic.^{[citation needed]}
• Hong Kong: Use and possession of cocaine is illegal unless a license was issued by the Department of Health.^{[citation needed]}
• India: Use and possession of cocaine is illegal with a mandatory 10-year sentence.^{[citation needed]}
• Mexico: As of August 25, 2009, the Mexican legislature officially legalized small doses of cocaine, heroin, marijuana, crystal meth, and ecstasy for personal use. No action will be taken for those carrying up to half a gram of cocaine.^{[28][29][30][31][32]}
• Netherlands: Cocaine is considered an illegal hard drug. Possession, production, and trade are not allowed as stated in the Opium Law of 1928. Although technically illegal, possession of less than half a gram usually goes unpunished.^[33][34]
• New Zealand: Cocaine is a Class A drug. The coca leaf and preparations of cocaine containing no more than 0.1% cocaine base, in such a way that the cocaine cannot be recovered, are both classified as Class C.^{[citation needed]}
• Nigeria: It is a crime to be seen with cocaine.^{[citation needed]}
• Pakistan: Use and possession of cocaine is illegal.^{[citation needed]}
• Peru: Cultivation of coca plants is legal and coca leaves are sold openly on markets. Similarly to Bolivia, chewing leaves and drinking coca tea belong to cultural practices. Possession of up to 2 grams of cocaine or up to 5 grams of cocaine basic paste is legal for personal use in Peru per Article 299 of Peruvian Penal Code.^[35] However, the reality of how police treats it might be very different.^[36] An important part of Article 299 is that person may not possess two or more kinds of drugs at the same time -- this would make it a criminal offense.
• Portugal: Personal use of cocaine is decriminalized. Drug abuse is dealt with by administrative and medical intervention. Trafficking is illegal.^[37]
• Saudi Arabia: Use and possession of cocaine is punishable by death.^{[citation needed]}
• Singapore: Possession of more than 30 grams of cocaine results in a mandatory death sentence, but can be issued by the Department of Health.^{[citation needed]}
• South Africa: It is a crime to have cocaine in your possession.^{[citation needed]}
• Switzerland: Personal use of cocaine is sentenced to a fine. Trafficking is sentenced to jail.^{[citation needed]}
• United Kingdom: Cocaine is a Class A drug, controlled by the Misuse of Drugs Act 1971. However, medical use by doctors for controlling pain is permitted.^{[citation needed]}
• United States: Cocaine is classified as a Schedule II Narcotic under the Controlled Substances Act of the United States.^[38]

See also

• Responsible use
• Stimulant
• Tropane alkaloid
• Dichloropane

External links

• Cocaine (Wikipedia)
• Cocaine paste (Wikipedia)
• Cocaine (Erowid Vault)
• Cocaine (Isomer Design)

References